Dissecting lipid metabolism alterations in SARS-CoV-2

Casari, Ilaria; Manfredi, Marcello; Metharom, Pat; Falasca, Marco

doi:10.1016/j.plipres.2021.101092

Cited by 101 publications

(102 citation statements)

References 228 publications

(200 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, the mature virions are released from the infected cell via exocytosis. The detailed life cycle of SARS-COV2 in host cells is referred to in the following literature ( 17 – 19 ). nsps, non-structural proteins; RTC, replication/transcription complex; ER, endoplasmic reticulum; ERGIC, ER-to-Golgi intermediate compartment.…”

Section: Glycans Of Viral Proteins and Their Functionsmentioning

confidence: 99%

The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection

Liu

Wang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Animal viruses are parasites of animal cells that have characteristics such as heredity and replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid bilayer membrane surrounds them or not. All the membrane proteins of enveloped viruses that function in attachment to target cells or membrane fusion are modified by glycosylation. Glycosylation is one of the most common post-translational modifications of proteins and plays an important role in many biological behaviors, such as protein folding and stabilization, virus attachment to target cell receptors and inhibition of antibody neutralization. Glycans of the host receptors can also regulate the attachment of the viruses and then influence the virus entry. With the development of glycosylation research technology, the research and development of novel virus vaccines and antiviral drugs based on glycan have received increasing attention. Here, we review the effects of host glycans and viral proteins on biological behaviors of viruses, and the opportunities for prevention and treatment of viral infectious diseases.

show abstract

Section: Glycans Of Viral Proteins and Their Functionsmentioning

confidence: 99%

The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection

Liu

Wang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In the context of viral infections, several studies reported a substantial alteration in lipid metabolism and lipoprotein composition [ 194 ]. Looking inside the mechanisms of infection, lipids are crucial in the infection process, as they are important structural components of cellular and subcellular organellar membranes [ 195 ].…”

Section: Dysregulation Of Lipidomic Profile During Sars-cov-2 Infectionmentioning

confidence: 99%

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Stasi

Franzin

Fiorentino

et al. 2021

IJMS

View full text Add to dashboard Cite

High-density lipoproteins (HDLs) are a class of blood particles, principally involved in mediating reverse cholesterol transport from peripheral tissue to liver. Omics approaches have identified crucial mediators in the HDL proteomic and lipidomic profile, which are involved in distinct pleiotropic functions. Besides their role as cholesterol transporter, HDLs display anti-inflammatory, anti-apoptotic, anti-thrombotic, and anti-infection properties. Experimental and clinical studies have unveiled significant changes in both HDL serum amount and composition that lead to dysregulated host immune response and endothelial dysfunction in the course of sepsis. Most SARS-Coronavirus-2-infected patients admitted to the intensive care unit showed common features of sepsis disease, such as the overwhelmed systemic inflammatory response and the alterations in serum lipid profile. Despite relevant advances, episodes of mild to moderate acute kidney injury (AKI), occurring during systemic inflammatory diseases, are associated with long-term complications, and high risk of mortality. The multi-faceted relationship of kidney dysfunction with dyslipidemia and inflammation encourages to deepen the clarification of the mechanisms connecting these elements. This review analyzes the multifaced roles of HDL in inflammatory diseases, the renal involvement in lipid metabolism, and the novel potential HDL-based therapies.

show abstract

“…Concerning posterior segment commitment, flame-shaped or microhemorrhages and cotton wool spots in the papillomacular bundle were shown 7 – 9 . Other reported systemic symptoms include shortness of breath, chest pain, headaches, neurocognitive difficulties, muscle pains and weakness, gastrointestinal upset, rashes, metabolic disruption (such as poor control of diabetes), thromboembolic conditions, depression, and other mental health conditions 10 – 12 .…”

Section: Introductionmentioning

confidence: 99%

Ocular findings among patients surviving COVID-19

Costa

Bonifácio

Bellíssimo-Rodrigues

et al. 2021

Sci Rep

View full text Add to dashboard Cite

To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmoscopy, color fundus picture, and retinal architecture evaluation using optical coherence tomography. Socio-demographic data and personal medical history were also collected. According to the severity of systemic manifestations, patients were classified into mild-to-moderate, severe, and critical. Sixty-four patients (128 eyes) were evaluated 82 ± 36.4 days after the onset of COVID’s symptoms. The mean ± SD duration of hospitalization was 15.0 ± 10.7 days. Seven patients (10.9%) had mild-to-moderate, 33 (51.5%) severe, and 24 (37.5%) critical disease. Median [interquartile ranges (IQR)] presenting visual acuity was 0.1 (0–0.2) and BCVA 0 (0–0.1). Anterior segment biomicroscopy was unremarkable, except for dry eye disease, verified in 10.9% of them. The mean ± SD intraocular pressure (IOP) in critical group (14.16 ± 1.88 mmHg) was significantly higher than in severe group (12.51 ± 2.40 mmHg), both in the right (p 0.02) and left eyes (p 0.038). Among all, 15.6% had diabetic retinopathy, and two patients presented with discrete white-yellowish dots in the posterior pole, leading to hyporreflective changes at retinal pigment epithelium level, outer segment, and ellipsoid layers. The present study identified higher IOP among critical cases, when compared to severe cases, and discrete outer retina changes 80 days after COVID-19 infection. No sign of uveitis was found.

show abstract

Dissecting lipid metabolism alterations in SARS-CoV-2

Cited by 101 publications

References 228 publications

The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection

The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Ocular findings among patients surviving COVID-19

Contact Info

Product

Resources

About