2020
DOI: 10.21203/rs.3.rs-45400/v1
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Dissecting Molecular Mechanisms Underlying H2O2-induced Apoptosis of Mouse Bone Marrow Mesenchymal Stem Cell: Role of Mst1 Inhibition.

Abstract: Background Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading to poor survival and engraft efficiency. Thus, improving the ability of BM-MSCs to scavenge ROS may considerably enhance the effectiveness of transplantation therapy. Mammalian Ste20-like kinase 1 (Mst1) is a pro-apoptotic molecule which increases ROS production. The aim of this study is to uncover whet… Show more

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“…Ionizing radiations represent the main source of DNA damage and ROS production in HSCs, indeed, increased ROS in HSCs initiates their differentiation and their exhaustion 32,33 and quiescent HSC with the lowest level of ROS have the highest haematopoietic reconstitution potential compared to ‘activated’ HSC harbouring higher ROS levels 34 . Geng et al documented that MST1/2 was vital for ROS‐mediated innate anti‐bacterial response 18 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Ionizing radiations represent the main source of DNA damage and ROS production in HSCs, indeed, increased ROS in HSCs initiates their differentiation and their exhaustion 32,33 and quiescent HSC with the lowest level of ROS have the highest haematopoietic reconstitution potential compared to ‘activated’ HSC harbouring higher ROS levels 34 . Geng et al documented that MST1/2 was vital for ROS‐mediated innate anti‐bacterial response 18 .…”
Section: Discussionmentioning
confidence: 99%
“…Geng et al documented that MST1/2 was vital for ROS‐mediated innate anti‐bacterial response 18 . But on the other hand, MST1 inhibition mediated the cytoprotective action of mBM‐MSCs against H 2 O 2 ‐induced oxidative stress injury 34 . The underlying mechanisms involve autophagy activation and the Keap1/Nrf2 signal pathway.…”
Section: Discussionmentioning
confidence: 99%