Dissecting respiratory disease heterogeneity through the genetics of diffusing capacity

Hobbs, Brian D.; Cho, Michael H.

doi:10.1183/13993003.01468-2018

Cited by 2 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Respiratory diseases present with significant heterogeneity among patients, creating considerable variability in disease onset, severity, and progression (6). Patient-specific regenerative cellbased therapies provide an attractive avenue to study pulmonary disease pathology and evaluate effective treatment regimes.…”

Section: Introductionmentioning

confidence: 99%

Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine

et al. 2021

View full text Add to dashboard Cite

Biomaterials intentionally designed to support the expansion, differentiation, and three-dimensional (3D) culture of induced-pluripotent stem cells (iPSCs) may pave the way to cell-based therapies for chronic respiratory diseases. These conditions are endured by millions of people worldwide and represent a significant cause of morbidity and mortality. Currently, there are no effective treatments for the majority of advanced lung diseases and lung transplantation remains the only hope for many chronically ill patients. Key opinion leaders speculate that the novel coronavirus, COVID-19, may lead to long-term lung damage, further exacerbating the need for regenerative therapies. New strategies for regenerative cell-based therapies harness the differentiation capability of human iPSCs for studying pulmonary disease pathogenesis and treatment. Excitingly, biomaterials are a cell culture platform that can be precisely designed to direct stem cell differentiation. Here, we present a closer look at the state-of-the-art of iPSC differentiation for pulmonary engineering, offer evidence supporting the power of biomaterials to improve stem cell differentiation, and discuss our perspective on the potential for tissue-informed biomaterials to transform pulmonary regenerative medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine

et al. 2021

View full text Add to dashboard Cite

show abstract

Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells

Ström

Merid²,

Pourazar

et al. 2022

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Dissecting respiratory disease heterogeneity through the genetics of diffusing capacity

Abstract: Genome-wide association studies of physiological measurements, such as diffusing capacity, can help to explore the genetic underpinnings of respiratory disease clinical heterogeneity http://ow.ly/aXMx30ltt4f

Cited by 2 publications

References 31 publications

Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine

Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine

Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells

Contact Info

Product

Resources

About