2020
DOI: 10.1101/2020.08.20.259119
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Dissecting serotype-specific contributions to live oral cholera vaccine efficacy

Abstract: The O1 serogroup of Vibrio cholerae causes pandemic cholera and is divided into Ogawa and Inaba serotypes. The O-antigen is the immunodominant antigen of V. cholerae, and the two serotypes, which differ by the presence or absence of a terminally methylated O-antigen, likely influence development of immunity to cholera and oral cholera vaccines (OCVs). However, there is no consensus regarding the relative immunological potency of each serotype, in part because previous studies relied on genetically heterogenous… Show more

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