2024
DOI: 10.1002/1873-3468.14896
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Dissecting the Ca2+ dependence of DesA1 function in Mycobacterium tuberculosis

Mamata Savanagouder,
Ravi Prasad Mukku,
Uday Kiran
et al.

Abstract: Mycobacterium tuberculosis (M. tb) has a complex cell wall, composed largely of mycolic acids, that are crucial to its structural maintenance. The M. tb desaturase A1 (DesA1) is an essential Ca2+‐binding protein that catalyses a key step in mycolic acid biosynthesis. To investigate the structural and functional significance of Ca2+ binding, we introduced mutations at key residues in its Ca2+‐binding βγ‐crystallin motif to generate DesA1F303A, E304Q, and F303A‐E304Q. Complementation of a conditional ΔdesA1 stra… Show more

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