2006
DOI: 10.1385/ir:36:1:51
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Dissecting the Humoral Immune Response to Simian Immunodeficiency Virus: Mechanisms of Antibody-Mediated Virus Neutralization

Abstract: The ultimate goal of an AIDS vaccine is to elicit potent cellular and humoral immune responses that will result in broadly enduring protective immunity. During the past several years, we have focused on characterizing the quantitative and qualitative properties of the antibody response, principally working to define the mechanism(s) of antibody-mediated neutralization in vitro. We have utilized a panel of monoclonal antibodies generated from monkeys infected with attenuated SIV for more than 8 mo to dissect th… Show more

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Cited by 2 publications
(2 citation statements)
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“…cART treatment was initiated between Day 184–189 post-infection, and resulted in a rapid decline in plasma viral RNA, to below the limit of detection (<30 copies/mL), ~4 weeks after treatment initiation. Consistent with previously published studies in both RM 26 and humans 27 , and with the development of an anti-SHIV serologic response, all animals developed high titers of whole virus-reactive antibodies (Fig. 1b ), with peak average titers in the range of 10 4 –10 5 detected between days 100–200 post-infection.…”
Section: Resultssupporting
confidence: 91%
“…cART treatment was initiated between Day 184–189 post-infection, and resulted in a rapid decline in plasma viral RNA, to below the limit of detection (<30 copies/mL), ~4 weeks after treatment initiation. Consistent with previously published studies in both RM 26 and humans 27 , and with the development of an anti-SHIV serologic response, all animals developed high titers of whole virus-reactive antibodies (Fig. 1b ), with peak average titers in the range of 10 4 –10 5 detected between days 100–200 post-infection.…”
Section: Resultssupporting
confidence: 91%
“…Env from all three strains of SIV displayed minor conformational changes upon sCD4 binding as compared to their respective native conformations (58), which in SIVmneE11S and SIVmac239 are observed as a slight opening at the apex of trimeric Env. Despite similar minor conformational changes in Env with sCD4 binding, these SIV strains have varied pathogenicities, antigenicities, and neutralization sensitivities (8,18,20,29,48,56).…”
Section: Discussionmentioning
confidence: 99%