Dissecting the microvascular contributions to diffuse correlation spectroscopy measurements of cerebral hemodynamics using optical coherence tomography angiography

Jang, James H.; Solarana, Krystyna; Hammer, Daniel X.; Fisher, Joan M.

doi:10.1117/1.nph.8.2.025006

Cited by 1 publication

(1 citation statement)

References 64 publications

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“…The fact that the dilation we observed in microvasculature was persistent and not associated with sensory activation suggests that the effect is not simply a reflection of FUS-triggered hyperaemia secondary to acute neural activation; for instance, we have previously shown that acute, sensory activation evokes increases in capillary blood flow that subside within ~10 sec (Jang et al, 2021). If our microvascular trends do indeed reflect a response to neuronal effects, they may be more likely related to the prolonged elevated excitability described by Clennell et al (2011).…”

Section: Discussionmentioning

confidence: 62%

Label free, capillary-scale blood flow mappingin vivoreveals that low intensity focused ultrasound evokes persistent dilation in cortical microvasculature

Shen,

Jethe,

Hehir

et al. 2024

Preprint

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Non-invasive, low intensity focused ultrasound (FUS) is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported. The brain's ability to provide targeted blood flow to electrically active regions involve a multitude of non-neuronal cell types and signaling pathways in the cerebral vasculature; an open question is whether persistent effects can be attributed, at least partly, to vascular mechanisms. Using a novel in vivo optical approach, we found that microvascular responses, unlike larger vessels which prior investigations have explored, exhibit persistent dilation. This finding and approach offers a heretofore unseen aspect of the effects of FUS in vivo and indicate that concurrent changes in neurovascular function may partially underly persistent neuromodulatory effects.

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Section: Discussionmentioning

confidence: 62%