Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure

Zheng, Baixiu; Zheng, Yanrong; Hu, Weiwei; Chen, Zhong

doi:10.1007/s00204-024-03733-2

Arch Toxicol

2024

DOI: 10.1007/s00204-024-03733-2

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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure

Baixiu Zheng,

Yanrong Zheng,

Weiwei Hu

et al.

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2024

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Dexamethasone reduces cytokine mRNA levels and microglial activity in the brainstem of newborn rats

Kalinina,

Bulygina,

Lanshakov

et al. 2024

Nejrohimiâ

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During the perinatal period of ontogenesis microglia, take part functions as a critical key-regulator of the angio-, neuro- and synaptogenesis processes. Under normal development, without inflammation induction, administration of the glucocorticoid hormone dexamethasone (0.2 mg/kg) caused a rapid decrease in the mRNA levels of both pro- and anti-inflammatory cytokines in the brainstem of neonatal rat pups. A decrease in the expression of the Il1b, Tnfa genes was observed within 1 hour, and Il10, Tgfb1 4 hours after the administration of the hormone to 3-day-old rat pups. Suppression of cytokine mRNA levels was accompanied by a decrease in the number of cells expressing the microglia marker protein IBA1 in the locus coeruleus region of the brain stem in 6 hours after glucocorticoid administration. The identified features of the dexamethasone action can weaken the participation of microglia in the processes of neuroplasticity in the developing brain, which may be one of the reasons for long-term changes in brain functioning.

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Dexamethasone reduces cytokine mRNA levels and microglial activity in the brainstem of newborn rats

Kalinina,

Bulygina,

Lanshakov

et al. 2024

Nejrohimiâ

View full text Add to dashboard Cite

show abstract

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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure

Cited by 1 publication

References 101 publications

Dexamethasone reduces cytokine mRNA levels and microglial activity in the brainstem of newborn rats

Dexamethasone reduces cytokine mRNA levels and microglial activity in the brainstem of newborn rats

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