Dissection of long-range heart rate variability

Roach, Daniel E.; Wilson, Warren J.; Ritchie, Debbie; Sheldon, Robert S.

doi:10.1016/j.jacc.2004.01.050

Cited by 65 publications

(21 citation statements)

References 28 publications

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“…These discrepant findings may be due to differences in the assessment of depression, in the techniques of HRV analysis, or in the ability to control for confounding factors. Unlike the current study, community studies have not controlled for physical activity, which was shown to influence ULF and VLF (27,28). Our study overcomes many limitations of previous studies by assessing twin pairs and employing a tight control of activity levels and other environmental factors during HRV recording.…”

Section: Discussionmentioning

confidence: 83%

“…However, VLF may also be influenced by other neurohormonal influences, such as the renin-angiotensin-aldosterone system, and LF may be influenced by sympathetic influences (28,54). ULF may be affected by day-night changes in heart period, especially when activity is controlled (27,55); these changes, in turn, may be influenced by autonomic activity. Although sympathetic activity is not well measured by HRV (56), our findings suggest that disordered parasympathetic regulation and depression may be linked.…”

Section: Discussionmentioning

confidence: 99%

“…For example, high- and low-frequency power HRV may be affected by changes in respiration that accompany every day activities, such as talking or mental tasks (26), which, in turn, may be influenced by depression. Long-range HRV (ultra low-frequency power) is influenced by physical activity (27), another factor likely to be affected by depression. It is therefore important to standardize environmental situations when examining HRV data (28).…”

Section: Introductionmentioning

confidence: 99%

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Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins

Vaccarino

Lampert

Bremner

et al. 2008

Psychosomatic Medicine

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Objective To clarify the relationship between depression and heart rate variability (HRV) in a sample of twins. Reduced HRV, a measure of autonomic dysfunction, has been linked to depression but many studies have inadequately controlled for familial and environmental factors. Furthermore, little is known about whether depression and HRV share common genetic pathways. Methods We performed power spectral analysis on 24-hour ambulatory electrocardiograms in 288 middle-aged male twins. Log-normalized ultra low, very low, low, high frequency, and total power were calculated. A lifetime history of major depressive disorder (MDD) was determined, using the Structured Clinical Interview for Psychiatry Disorders, and current depressive symptoms were measured with the Beck Depression Inventory. Mixed-effect regression models were used to account for intrapair variability and estimate within-pair effects at the same time controlling for potential confounders. Results Both current depressive symptoms and a history of MDD were significantly associated with lower HRV. There was a graded effect, and power in each frequency band was 29% to 36% lower in the lowest band compared with the highest BDI category. All HRV measures except high frequency remained significantly associated with current depressive symptoms in multivariable analysis, but not with lifetime history of MDD. When analyses were stratified by zygosity, a significant within-pair association between BDI score and HRV was found in the dizygotic but not in the monozygotic twins, suggesting a genetic influence on the association. Conclusions A shared, genetically influenced biological pathway underlies the association between depression and lower HRV. These two phenotypes may be the expression of a generalized neurobiological perturbation.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins

Vaccarino

Lampert

Bremner

et al. 2008

Psychosomatic Medicine

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“…Support for this interpretation comes from a study by Sajadieh et al [97], where associations of 24-h HRV with several RF (e.g. physical activity, smoking) were attenuated when only a 15-min night-time segment of the ECG was analyzed, and a study by Roach [105]. Serrador et al [106] also pointed out that short-term HRV at rest may better reflect intrinsic HRV than longterm HRV which could be affected by variation in physical activity.…”

Section: Behavioural Rfmentioning

confidence: 98%

Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002–2006

et al. 2009

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“…Both SDNN, reflecting all variance, and ULF, reflecting variance below .0033Hz, reflect circadian variation, which is autonomically controlled (33). ULF also reflects non-harmonic variations in heart rate, such as those due to physical activity (41). Physical activity has not been found to influence SDNN (40).…”

Section: Introductionmentioning

confidence: 99%

Cumulative stress and autonomic dysregulation in a community sample

Lampert

Tuit

Hong

et al. 2016

Stress

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Whether cumulative stress, including both chronic stress and adverse life events, is associated with decreased heart rate variability (HRV), a non-invasive measure of autonomic status which predicts poor cardiovascular outcomes, is unknown. Healthy community dwelling volunteers, (N= 157, mean age 29 years) participated in the Cumulative Stress/Adversity Interview, (CAI) a 140-item event interview measuring cumulative adversity including major life events, life trauma, recent life events and chronic stressors, and underwent 24 hour ambulatory ECG monitoring. HRV was analyzed in the frequency domain and standard deviation of NN intervals (SDNN) calculated. Initial simple regression analyses revealed that total cumulative stress score, chronic stressors, and cumulative adverse life events (CALE) were all inversely associated with ultra low frequency (ULF), very low frequency (VLF), and low frequency (LF) power and SDNN (all p<0.05). In hierarchical regression analyses, total cumulative stress and chronic stress each was significantly associated with SDNN and ULF even after the high significant contribution of age and sex, with no other covariates accounting for additional appreciable variance. For VLF and LF, both total cumulative stress and chronic stress significantly contributed to the variance were no longer significant after adjusting for race and health behaviors. (p’s<.05). In summary, total cumulative stress, and its components of adverse life events and chronic stress were associated with decreased cardiac autonomic function as measured by HRV. Findings suggest one potential mechanism by which stress may exert adverse effects on mortality in healthy individuals. Primary preventive strategies including stress management may prove beneficial.

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Dissection of long-range heart rate variability

Abstract: Activity increases SDANN by increasing the range of heart periods. Patients with diminished ventricular function have a reduced SDANN on ambulatory electrocardiograms, possibly and partly because of a higher mean heart rate and reduced variations in physical activity.

Cited by 65 publications

References 28 publications

Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins

Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins

Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002–2006

Cumulative stress and autonomic dysregulation in a community sample

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