2019
DOI: 10.1177/0192623319854338
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Dissection of the Trigeminal Ganglion of Nonrodent Species Used in Toxicology Studies

Abstract: The ganglion of the trigeminal (V cranial) nerve is generally sampled at necropsy in nonrodent toxicology studies only when somatic or autonomic peripheral nervous system toxicity is suspected. The ganglion is far more difficult to locate in nonrodents than in rats and mice, and suitable methods to dissect it have been described only for swine. The trigeminal nerve caudal to the ganglion passes through a canal, roofed by bone in dogs and rabbits and by a tough layer of dura mater in swine and nonhuman primates… Show more

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Cited by 12 publications
(19 citation statements)
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“…These bilaterally paired ganglia are collections of sensory neurons located at the base of the skull, typically bracketing the pituitary gland. 14 Branches of the trigeminal nerve include both sensory and motor fibers.…”
Section: Introductionmentioning
confidence: 99%
“…These bilaterally paired ganglia are collections of sensory neurons located at the base of the skull, typically bracketing the pituitary gland. 14 Branches of the trigeminal nerve include both sensory and motor fibers.…”
Section: Introductionmentioning
confidence: 99%
“…Trigeminal ganglia and autonomic ganglia (eg, cranial [superior] cervical, cervicothoracic, and cranial mesenteric) may be gathered using published procedures. 75,82 Locations of major autonomic ganglia in minipigs could not be illustrated for the present satellite study because the torso was used to address the objective of the primary study, but the ganglionic positions in minipigs 83,84 are similar generally to those of equivalent ganglia in other nonrodent species. 71…”
Section: Resultsmentioning
confidence: 99%
“…In this regard, typical somatic ganglia collected at necropsy are the dorsal root ganglia (DRG) and sometimes the trigeminal ganglia (cranial nerve V). 71,75 These somatic sensory ganglia usually are evaluated if there is a possibility that a test article might target their neurons. 76,77 Autonomic ganglia (usually for the sympathetic division) typically are collected only if the test article or a related material has been shown to produce effects to autonomic function.…”
Section: Other Neural Organs: Spinal Cord Ganglia and Nervesmentioning
confidence: 99%
“…For most studies, sampling is typically limited to somatic sensory ganglia such as the DRG and trigeminal ganglia (cranial nerve V). 2,42 These sensory ganglia usually are sampled when there is a possibility to be targeted by a test article. [43][44][45][46] Autonomic ganglia generally are obtained for evaluation only as they occur within the walls of hollow nonneural organs sampled as part of the protocol-specified tissue list.…”
Section: Gangliamentioning
confidence: 99%