Disseminated actinomycetoma due to Nocardia wallacei

Abstract

Linezolid can be an alternative for the treatment of multidrug resistant Nocardia Wallacei.

Linezolid: a safer and effective substitute to aminoglycoside in the treatment of actinomycetoma by Nocardia species

“…have reported the use of linezolid in the specific management of actinomycotic mycetoma. Welsh et al 10 . reported the successful use of linezolid in the management of disseminated actinomycetoma due to Nocardia wallacei .…”

“…Though linezolid has been used successfully in treating disseminated systemic Nocardia infections, there are very few reports regarding the use of linezolid for actinomycetoma (Table 1). 3,[9][10][11] Epelboin et al 9 have reported the use of linezolid in the specific management of actinomycotic mycetoma.…”

“…Welsh et al 10 reported the successful use of linezolid in the management of disseminated actinomycetoma due to Nocardia wallacei. Sardana et al had treated four cases with a regimen of linezolid 600 mg BD for three months along with TMP/SMX (trimethoprim 240 mg and sulfamethoxazole 1200 mg) for six months out of which three patients had a complete response.…”

A combination of trimethoprim/sulfamethoxazole with linezolid is useful for actinomycotic mycetoma: A summary of the existing data and the rationale of combination therapy

“…2 Mean time in which the lesion healed was three months. Previously, Welsch et al 3 and Epelboin et al 4 have also reported use of linezolid in the specific management of actinomycotic mycetoma.…”

Common Infections Following Lung Transplantation

“…Sensitivity to meropenem must be demonstrated in the laboratory before use [36]. • linezolid has excellent in vitro activity against Nocardia and has been used with success in treatment; therefore linezolid may be used as part of a multi-drug regimen [37,38]. • if the patient has a TMP-SMX allergy desensitisation should be performed if possible.…”