Disseminated Acute Concomitant Aspergillosis and Mucormycosis in a Pony

Thirion-Delalande, Catherine; Guillot, Jacques; Jensen, Henrik Elvang; Crespeau, François; Bernex, Florence

doi:10.1111/j.1439-0442.2005.00700.x

Cited by 32 publications

(19 citation statements)

References 16 publications

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“…Cerebral mixed fungal infections (cases 6 and 7 of the present study) or with a fungus and a bacterium are considered rare, but have been previously observed in mammals (e.g. 1,3,[32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Tauber

Eiffert

Kellner

et al. 2014

Neuropathology Appl Neurobio

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Section: Discussionmentioning

confidence: 99%

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Tauber

Eiffert

Kellner

et al. 2014

Neuropathology Appl Neurobio

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“…In a recent study on stork chicks, L. corymbifera was identified as the second most common cause of fungal pneumonia, accountable for 18% of the cases . In both mammalian and avian hosts, Lichtheimia can occur as coinfection with A. fumigatus …”

Section: Lichtheimia Infections In Animalsmentioning

confidence: 99%

“…69 In both mammalian and avian hosts, Lichtheimia can occur as coinfection with A. fumigatus. 62,69,70 Infection models for Lichtheimia…”

Section: Lichtheimia Infections In Animalsmentioning

confidence: 99%

Mucormycoses caused byLichtheimiaspecies

Schwartze

Jacobsen

2014

Mycoses

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SummaryMucormycoses are life-threatening infections with fungi from the order Mucorales (Mucoromycotina). Although mucormycoses are uncommon compared to other fungal infections, e.g. aspergillosis and candidiasis, the number of cases is increasing especially in immunocompromised patients. Lichtheimia (formerly Absidia) species represent the second to third most common cause of mucormycoses in Europe. This mini review presents current knowledge about taxonomy and clinical relevance of Lichtheimia species. In addition, clinical presentation and risk factors will be discussed. Proper animal infection models are essential for the understanding of the pathogenesis and the identification of virulence factors of fungal pathogens. To date, several animal models have been used to study Lichtheimia infection. A brief overview of the different models and the main conclusions from the infection experiments is summarised in this review.

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“…Reported equine mycotic encephalitis cases include 4 reports of aspergillosis, 17,18,24 1 of which had a concurrent Mucor sp . infection, 38 and 1 report of cryptococcosis. 39 Across species, Cryptococcus spp .…”

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confidence: 99%

Chaetomiaceae Fungi, Novel Pathogens of Equine Neurotropic Phaeohyphomycosis

et al. 2017

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Many previously unrecognized fungi are emerging as potential pathogens. One such group is dematiaceous fungi of the Chaetomiaceae family (phylum Ascomycota, class Sordariomycetes). These fungi are rare causes of opportunistic, neurotropic phaeohyphomycosis in humans but are not known to cause similar infections in animals. The aims of this study were to investigate equine hyphal mycotic encephalitis, characterize key histopathologic features, and classify causative organisms with molecular diagnostic techniques. Seven cases were evaluated by histopathology. Panfungal PCR targeting the ribosomal RNA large subunit coding region and the noncoding internal transcribed spacer-2 region was performed on DNA extracted from formalin-fixed, paraffin-embedded sections of affected brain, and the resulting sequences were queried against published fungal genomes. Affected animals ranged from 8 to 22 years of age and presented with neurologic signs. Macroscopic lesions within affected brains included multifocal hemorrhage, focal swelling of the thalamus with red and yellow discoloration, and focal cerebral malacia. Major histologic findings included multifocal discrete foci of necrosis, neutrophilic to granulomatous inflammation, vasculitis, and intralesional fungal hyphae variably affecting the cerebrum, thalamus, and brainstem. DNA sequences in 4 cases showed > 98% homology with species within the Chaetomiaceae family, including Acrophialophora fusispora, Acrophialophora levis, and Chaetomium strumarium. Histomorphologically, Chaetomiaceae fungi were 7 to 10 μm wide, septate, parallel walled, and nonpigmented, with dichotomous branching in affected horses. This case series is the first report of equine mycotic encephalitis caused by members of the Chaetomiaceae family, previously reported as rare emerging pathogens in humans.

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Disseminated Acute Concomitant Aspergillosis and Mucormycosis in a Pony

Cited by 32 publications

References 16 publications

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Mucormycoses caused byLichtheimiaspecies

Chaetomiaceae Fungi, Novel Pathogens of Equine Neurotropic Phaeohyphomycosis

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