Disseminated adenoviral disease in immunocompetent adults supported with extracorporeal membrane oxygenation

Kavita, Murughan; Chang, Grace; Ngai, Melissa; Tang, Simeon; MacLaren, Graeme; Ramanathan, Kollengode

doi:10.21037/jtd-19-2096

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…In terms of laboratory results, HAdVs associated with ARDS showed unfavorable levels of biomarkers of hepatic injury (elevated transaminase and total bilirubin, decreased albumin), cardiac injury (elevated creatine kinase and creatine kinase isoenzyme MB), and kidney injury (elevated creatinine and blood urea nitrogen). Furthermore, the data on complications gathered in this study, together with the previous cases [ 8 , 41 , 42 ], confirm that HAdV-associated ARDS that occurred along with one or more organ injuries (including liver, kidney, and cardiac) was common in adult immunocompetent patients. The reasons for this are multifactorial, and the specific mechanisms remain unclear.…”

Section: Discussionsupporting

confidence: 82%

A prediction model for acute respiratory distress syndrome in immunocompetent adults with adenovirus-associated Pneumonia: a multicenter retrospective analysis

Lin,

Zhou,

et al. 2023

BMC Pulm Med

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Background In recent years, the number of human adenovirus (HAdV)-related pneumonia cases has increased in immunocompetent adults. Acute respiratory distress syndrome (ARDS) in these patients is the predominant cause of HADV-associated fatality rates. This study aimed to identify early risk factors to predict early HAdV-related ARDS. Methods Data from immunocompetent adults with HAdV pneumonia between June 2018 and May 2022 in ten tertiary general hospitals in central China was analyzed retrospectively. Patients were categorized into the ARDS group based on the Berlin definition. The prediction model of HAdV-related ARDS was developed using multivariate stepwise logistic regression and visualized using a nomogram. Results Of 102 patients with adenovirus pneumonia, 41 (40.2%) developed ARDS. Overall, most patients were male (94.1%), the median age was 38.0 years. Multivariate logistic regression showed that dyspnea, SOFA (Sequential Organ Failure Assessment) score, lactate dehydrogenase (LDH) and mechanical ventilation status were independent risk factors for this development, which has a high mortality rate (41.5%). Incorporating these factors, we established a nomogram with good concordance statistics of 0.904 (95% CI 0.844–0.963) which may help to predict early HAdV-related ARDS. Conclusion A nomogram with good accuracy in the early prediction of ARDS in patients with HAdV-associated pneumonia may could contribute to the early management and effective treatment of severe HAdV infection.

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Section: Discussionsupporting

confidence: 82%

A prediction model for acute respiratory distress syndrome in immunocompetent adults with adenovirus-associated Pneumonia: a multicenter retrospective analysis

Lin,

Zhou,

et al. 2023

BMC Pulm Med

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“…Human adenoviruses (HAdVs) are intriguing and clinically relevant pathogens that mainly cause ocular, respiratory, and gastrointestinal tract infections [ 1 , 2 ]. HAdV infection can be associated with high morbidities and case-fatality rates in both immunocompetent and immunocompromised patients, and especially in children [ [3] , [4] , [5] , [6] ]. Human and animal adenoviruses are used as vectors in clinical gene therapy settings and vaccinology for more than three decades and their use as vaccine vectors culminated with the SARS-CoV-2 pandemic [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro

Ip¹,

Bertzbach²,

Speiseder³

et al. 2023

Tumour Virus Research

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“…Disseminated disease can occur in allogeneic hematopoietic stem cell transplant (HSCT) or cordblood transplant patients (5,6). However, it has also been described in other immunocompromised patients such as those on chemotherapy (4,(7)(8)(9), solid organ transplant recipients (10), human immunode ciency virus-positive individuals (11), premature infants (12,13), and very rarely in immunocompetent adults (14)(15)(16). Disseminated disease is more commonly associated with HAdV types A31, C1, C2, C5 and B21 (10,17) but cases involving other types have been described (18).…”

Section: Introductionmentioning

confidence: 99%

Dissemination and Genome Characterization of a Human Adenovirus F41 in a Patient with B-Cell Lymphoma

Fall

Campodonico

Howard

et al. 2022

Preprint

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Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, a fifty-eight-year-case with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient’s course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient’s infecting virus was characterized as HAdV-F41 by whole genome sequencing.

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Disseminated adenoviral disease in immunocompetent adults supported with extracorporeal membrane oxygenation

Cited by 5 publications

References 22 publications

A prediction model for acute respiratory distress syndrome in immunocompetent adults with adenovirus-associated Pneumonia: a multicenter retrospective analysis

A prediction model for acute respiratory distress syndrome in immunocompetent adults with adenovirus-associated Pneumonia: a multicenter retrospective analysis

The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro

Dissemination and Genome Characterization of a Human Adenovirus F41 in a Patient with B-Cell Lymphoma

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