Disseminated Candida infection syndrome in heroin addicts--dominance of a single Candida albicans biotype

Odds, Frank C.; Palacio-Hernanz, A. Del; Cuadra, J.; Sánchez, José Pardo

doi:10.1099/00222615-23-3-275

Cited by 28 publications

(14 citation statements)

References 11 publications

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“…Of all the reports of candida fungemia, intravenous drug use appears to be an important risk factor 12–14. In the vast majority of these cases, the infectious strain has been C. albicans , not C. dubliniensis , and there are only a few reports of C. dubliniensis fungemia in HIV-negative, non-transplant patients 10 15…”

Section: Discussionmentioning

confidence: 99%

The first documented case of Candida dubliniensis leptomeningeal disease in an immunocompetent host

Andrew

Ruberu²,

Gabb³

2011

Case Reports

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Section: Discussionmentioning

confidence: 99%

The first documented case of Candida dubliniensis leptomeningeal disease in an immunocompetent host

Andrew

Ruberu²,

Gabb³

2011

Case Reports

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“…In the original application of this method to oral and vaginal isolates, 45 different types were identified (240), but the system had the potential for discriminating 512 types. The use of this biotyping strategy proved effective in a number of epidemiological studies (see, e.g., references 166,189,235,244,245,247,248,276,342, and 434), and if care was taken in standardizing methods, intralaboratory reproducibility could be achieved. Unfortunately, the Odds and Abbott biotyping system was found to have poor interlaboratory reproducibility among five laboratories (242).…”

Section: Biotyping Is Inadequate As a Dna Fingerprinting Methodsmentioning

confidence: 99%

“…The dominant scenario, however, has proven to be single-strain maintenance. This scenario was first suggested in biotyping studies (166,235,245,247,262,342) and soon thereafter verified by a variety of genetic fingerprinting methods. In 1988, Soll et al monitored a single patient with a C. tropicalis BSI over a 2-month period using Southern blot hybridization with a C. tropicalis-specific complex probe and demonstrated that two strains persistently infected the bloodstream (360).…”

Section: Strain Maintenance During Persistent or Recurrent Infectionmentioning

confidence: 99%

The Ins and Outs of DNA Fingerprinting the Infectious Fungi

Soll

2000

Clinical Microbiology Reviews

283

317

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“…Each number represents an isolate from a different patient. b Isolates from cutaneous lesions in patients with heroin-associated disseminated candidosis that gives rise to nodular dermal lesions[15]. The numbers 1.505, 1.509 and 1.459 each indicate a single patient; the numbers in parentheses indicate isolates from separate cutaneous lesions.…”

mentioning

confidence: 99%

Expression of an epitope by surface glycoproteins ofCandida albicans. Variability among species, strains and yeast cells of the genusCandida

Fruit¹,

Cailliez²,

Odds³

et al. 1990

Med Mycol

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Expression of an antigenic epitope reactive with an IgM monoclonal antibody was studied in 253 Candida isolates by direct agglutination. Isolates of Candida albicans reacted significantly more often with the antibody than did isolates of other species. The agglutination scores for C. albicans isolates from sources associated with possible deep-seated Candida infection were significantly higher than for those from other sources. However, there was considerable overlap of scores between these two groups so that the functional significance of the association is uncertain. There were no associations between agglutination score and C.albicans biotype: multiple isolates from individual patients gave similar agglutination scores.Expression of the epitope within colonies of cloned strains was studied by autoradiography of colony blots on nitrocellulose and by immunoperoxidase staining of colonies in situ. It was found that the epitope was expressed variably by portions of colonies of both agglutinationpositive and agglutination-negative strains. Indirect immunofluorescence revealed that expression of the epitope at the surface of C. albicans germ tubes and their associated buds was variable from cell to cell. It was not directly related to morphology or stage of growth of the cells.Several anti-Candida albicans monoclonal antibodies have been described in the literature. They have been proposed as diagnostic agents for detection of circulating Candida antigens [18,23,25], for taxonomic use in the identification of Candida species [ 12,17] and for epidemiological studies [5,9,17]. However, regardless of the potential value of monoclonal antibodies for each of these applications, no definitive assessment of them can be achieved in the absence of exhaustive studies on the distribution of the epitopes with which they react. It is important to know the occurrence of the epitopes among yeast genera, species and strains (i.e. their genotypic character), and also their modes of expression under different culture conditions and in different phases of the cell cycle (their phenotypic character).Previous studies of monoclonal antibodies directed against surface mannoproteins of Candida have provided evidence of the extreme variability in the expression of

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Disseminated Candida infection syndrome in heroin addicts--dominance of a single Candida albicans biotype

Cited by 28 publications

References 11 publications

The first documented case of Candida dubliniensis leptomeningeal disease in an immunocompetent host

The first documented case of Candida dubliniensis leptomeningeal disease in an immunocompetent host

The Ins and Outs of DNA Fingerprinting the Infectious Fungi

Expression of an epitope by surface glycoproteins ofCandida albicans. Variability among species, strains and yeast cells of the genusCandida

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