Disseminated Chrysosporium infection in a German shepherd dog

Cook, Emily K; Meler, Erika; Garrett, Katrina; Long, Hanna; Mak, K. F.; Stephens, Carol; Thompson, Andrea

doi:10.1016/j.mmcr.2016.01.002

Cited by 17 publications

(7 citation statements)

References 18 publications

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“…), in a German shepherd dog with disseminated Chrysosporium infection (Cook et al . ), in a cat with invasive orbital aspergillosis (McLellan et al . ), in a cat with localised Microsphaeropsis arundinis infection of the subcutis (Krockenberger et al .…”

Section: Introductionmentioning

confidence: 99%

Treatment of refractory sino‐nasal aspergillosis with posaconazole and terbinafine in 10 dogs

Stewart¹,

Bianco²

2017

J of Small Animal Practice

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Section: Introductionmentioning

confidence: 99%

Treatment of refractory sino‐nasal aspergillosis with posaconazole and terbinafine in 10 dogs

Stewart¹,

Bianco²

2017

J of Small Animal Practice

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“…Multiple agents have been identified to cause pyogranulomatous inflammation, including bacteria [Actinomyces, Bartonella (Pappalardo et al 2000, Pappalardo et al 2001, Saunders & Monroe 2006, Morales et al 2007, Tucker et al 2014, Drut et al 2014, Mycobacterium, Nocardia and Staphylococcus], fungi (Aspergillus, Blastomyces, Coccidioides, Cryptococcus, Histoplasma), oomycetes (Pythium) and protozoa (Neospora, Toxoplasma, Leishmania) (Mylonakis et al 2005, Greene 2012). Other infectious agents associated with granulomatous and pyogranulomatous lymphadenitis have also been recently reported, such as Rhodococcus equi (Bryan et al 2017), Sporotrichum pruinosum (Magstadt et al 2018), Cladosporium cladosporioides-complex (Spano et al 2018), Talaromyces helicus (Tomlinson et al 2011), Chrysosporium species (Cook et al 2016), Scytalidium (Dunlap et al 2015), Paracoccidioides brasiliensis (Headley et al 2017) and circovirus (Li et al 2013).…”

Section: Introductionmentioning

confidence: 97%

“…), Chrysosporium species (Cook et al . ), Scytalidium (Dunlap et al . ), Paracoccidioides brasiliensis (Headley et al .…”

Section: Introductionmentioning

confidence: 99%

Characterisation and outcome of idiopathic pyogranulomatous lymphadenitis in 64 English springer spaniel dogs

Dor

Gajanayake

Kortum

et al. 2019

J of Small Animal Practice

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Objectives To describe the history, clinicopathological abnormalities, diagnostic imaging findings, lymph node cytological/histological appearance, treatment and outcome of English springer spaniels diagnosed with idiopathic pyogranulomatous lymphadenitis. Materials and Methods In this retrospective UK‐based multicentre study, 64 dogs were recruited from 10 referral centres, 32 first‐opinion practices and three histopathology/cytology laboratories, between 2010 and 2016. Results The median age at presentation was 6 years (range: 0.17 to 11.75). Neutered females were frequently affected. Pyrexia (83.8%), peripheral lymphadenomegaly (78.4%), dermatological lesions (72.9%), lethargy (67.6%), hyporexia (54%), diarrhoea (29.7%), coughing (24.3%), epistaxis, sneezing or nasal discharge (21.6%), ocular signs (21.6%) and vomiting (16.2%) were reported in dogs for which the history and physical examination records were available. Popliteal (45.3%), superficial cervical (35.9%) and submandibular (37.5%) lymphadenomegaly were frequently reported. Haematology and serum biochemistry revealed non‐specific changes. When undertaken, testing for infectious diseases was negative in all cases. Lymph node cytology, histopathology or both demonstrated mixed inflammatory (27%), pyogranulomatous (24%), neutrophilic (20%) or granulomatous (11%) lymphadenitis. Treatment details were available for 38 dogs, with 34 receiving prednisolone for a median duration of 15 weeks (range: 1 to 28 weeks). A good to excellent clinical response was reported in all but one case. Ten dogs relapsed after discontinuing prednisolone. Clinical Significance Idiopathic pyogranulomatous lymphadenitis should be considered as a differential diagnosis for lymphadenopathy and pyrexia in English springer spaniels. The characteristics of the disease, absence of identifiable infectious aetiology and response to glucocorticoid therapy suggest an immune‐mediated aetiology.

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“…Of note, the German Shepherd Dog (GSD) appears to be overrepresented within the population of dogs with CAF, with more than 80% of dogs suffering from CAF (CAF dogs) being GSD. 29,30 GSD is also susceptible to inflammatory bowel disease (IBD), 31,32 systemic aspergillosis, [33][34][35][36] and deep pyoderma, 37,38 suggesting that GSD might have a broadly dysfunctional immune response to microbial exposure at epithelial surfaces, similar to human CD patients. Dogs have already proven useful for studying various other spontaneously occurring disorders similar to those affecting humans, 11,[39][40][41][42] and the dog microbiome is more similar to that of humans than it is to the microbiomes of other animals that are generally used as models of microbiome-centered diseases such as IBD (e.g., mice and pigs).…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis in a canine model of human fistulizing Crohn’s disease

et al. 2020

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Crohn's disease (CD) is a chronic immune-mediated inflammatory condition caused by the loss of mucosal tolerance toward the commensal microbiota. On average, 29.5% and 42.7% CD patients experience perianal complications at 10 and 20 y after diagnosis, respectively. Perianal CD (pCD) result in high disease burden, diminished quality of life, and elevated health-care costs. Overall pCD are predictors of poor long-term outcomes. Animal models of gut inflammation have failed to fully recapitulate the human manifestations of fistulizing CD. Here, we evaluated dogs with spontaneous canine anal furunculosis (CAF), a disease with clinical similarities to pCD, as a surrogate model for understanding the microbial contribution of human pCD pathophysiology. By comparing the gut microbiomes between dogs suffering from CAF (CAF dogs) and healthy dogs, we show CAF-dog microbiomes are either very dissimilar (dysbiotic) or similar (healthy-like), yet unique, to healthy dog's microbiomes. Compared to healthy or healthy-like CAF microbiomes, dysbiotic CAF microbiomes showed an increased abundance of Bacteroides vulgatus and Escherichia coli and a decreased abundance of Megamonas species and Prevotella copri. Our results mirror what have been reported in previous microbiome studies of patients with CD; particularly, CAF dogs exhibited two distinct microbiome composition: dysbiotic and healthy-like, with determinant bacterial taxa such as E. coli and P. copri that overlap what it has been found on their human counterpart. Thus, our results support the use of CAF dogs as a surrogate model to advance our understanding of microbial dynamics in pCD.

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Disseminated Chrysosporium infection in a German shepherd dog

Cited by 17 publications

References 18 publications

Treatment of refractory sino‐nasal aspergillosis with posaconazole and terbinafine in 10 dogs

Treatment of refractory sino‐nasal aspergillosis with posaconazole and terbinafine in 10 dogs

Characterisation and outcome of idiopathic pyogranulomatous lymphadenitis in 64 English springer spaniel dogs

Dysbiosis in a canine model of human fistulizing Crohn’s disease

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