Disseminated coccidioidomycosis masquerading as recurrent lymphoma

Manning, Marie A; Kuo, Phillip H.; Yeager, Andrew M.

doi:10.1136/bcr-2018-224965

Cited by 8 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these are not plausible explanations for CO and PH lesions found together in the precontact USSW due to geographic distributions of those diseases prior to contact with the Spanish (Blom et al, ; De Sanctis, ; Williams & Weatherall, ). In the precontact USSW potential causes for anemia include: intestinal parasites such as Escherichia coli and Salmonella (Bae et al, ; Reinhard, ; Ubelaker, ), hepatitis (Merbs, ; W.H.O., ), gastroenteritis (Al‐Laham et al, ; Merbs, ), and fungal infections ( coccidioidomycosis ) (Manning et al, ; Zhou et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Iron‐deficiency is a leading cause of anemia worldwide (Camaschella, ). However, other potential causes of anemia include: parasitic infections (Reinhard, , , ; Reinhard & Bryant, ; W.H.O., ), gastroenteritis (Al‐Laham, Elyazji, Al‐Haddad, & Ridwan, ; Merbs, ), congenital hemoglobinopathies (W.H.O., ; Williams & Weatherall, ), vitamin deficiencies (A, B 12 [folic acid], and C) (Cohen & Paeglow, ; Levavasseur et al, ; Semba & Bloem, ; Stabler, ), and fungal infections (such as coccidioidomycosis ) (Manning, Kuo, & Yeager, ; Zhou, Ma, & Chandrasoma, ). Aside from agreement that CO and PH lesions can develop in cases of anemia, there is not concordance on their exact etiology (McIlvaine, ; Oxenham, ; Oxenham & Cavill, ; Rothschild, , ; Walker et al, ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Indicators of stress and their association with frailty in the precontact Southwestern United States

O’Donnell

2019

American J Phys Anthropol

View full text Add to dashboard Cite

Objectives: Physiological disturbances in early life have been shown to increase individual mortality risk and impact health in adulthood. This study examines frailty through analysis of lesion status of two commonly collected skeletal indicators of stress (cribra orbitalia [CO] and porotic hyperostosis [PH]) and their association with mortality risk in the precontact U.S. Southwest. Several predictions are addressed: (a) individuals with active skeletal lesions are the frailest; (b) individuals with healed lesions are the least frail; (c) CO lesions, regardless of status, are associated with increased mortality risk. Materials and methods: Odds ratios and Kaplan-Meier survival analysis are used to examine the association between stress indicators and mortality in the U.S. Southwest. This study includes 335 individuals (75 females, 81 males, 20 adults of unknown sex, and 159 juveniles) from precontact New Mexico archaeological sites dating to A.D. 1,000-1,400. Results: Active CO and PH lesions are associated with lower survivorship and greater mortality risk than healed or absent lesions. Only juvenile individuals have active CO and PH lesions, as is expected given their physiology. CO lesions in any state are associated with greater mortality risk and earlier ages of death. Discussion: Individuals with active lesions are the frailest; while individuals with healed lesions are the least frail. CO and PH likely have different etiologies: CO lesions are associated with increased mortality risk and decreased individual longevity. These results indicate that CO's presence suggests a more severe underlying condition than PH lesions alone. K E Y W O R D S cribra orbitalia, hidden heterogeneity, porotic hyperostosis, stress, survival analysis

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Indicators of stress and their association with frailty in the precontact Southwestern United States

O’Donnell

2019

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…Anemia—tissue hypo‐oxygenation due to shortfalls in RBC performance or population—is a symptom of various conditions. These conditions may include malaria, menstruation, pregnancy and childbirth, injury, vitamin insufficiency, infectious diseases, fungal infections, parasites, congenital hemolytic disorders, and gastroenteritis (Al‐Laham, Elyazji, Al‐Haddad, & Ridwan, 2015; Camaschella, 2015; Cohen & Paeglow, 2001; Grauer, 2019; Manning, Kuo, & Yeager, 2018; Moll & Davis, 2017; Reinhard, 1992; Semba & Bloem, 2002; Stabler, 2013; W.H.O., 2003; White, 2018; Williams & Weatherall, 2012). In addition to IDA, it is possible that PCLs can result from megaloblastic anemia, which commonly develops in cases of Vitamin B 12 (cobalamin, herein, B 12 ) or folate deficiency (Brickley & Ives, 2008; Jatautis, Mitokaitė, & Jankauskas, 2011; Walker et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cribra orbitalia and porotic hyperostosis are associated with respiratory infections in a contemporary mortality sample from New Mexico

O’Donnell

Hill

Anderson

et al. 2020

American J Phys Anthropol

View full text Add to dashboard Cite

Objectives: Cribra orbitalia (CO) and porotic hyperostosis (PH) are porous cranial lesions (PCLs) classically associated with iron-deficiency anemia in bioarchaeological contexts. However, recent studies indicate a need to reassess the interpretation of PCLs. This study addresses the potential health correlates of PCLs in a contemporary sample by examining relationships between the known cause of death (COD) and PCL presence/absence. Methods: This study includes a sample of 461 juvenile individuals (6 months to 15 years of age) who underwent examination at the University of New Mexico's Office of the Medical Investigator between 2011 and 2019. The information available for each individual includes their sex, age at death, and their COD and manner of death. Results: Odds ratio of having CO (OR = 3.92, p < .01) or PH (OR = 2.86, p = .02) lesions are increased in individuals with respiratory infections. Individuals with heart conditions have increased odds of having CO (OR = 3.52, p = .03) lesions, but not PH. Conclusion: Individuals with respiratory infection are more likely to have CO and/or PH. CO appears to have a greater range of health correlates than PH does, as indicated by the heart condition results. However, individuals with congenital heart defects are at higher risk for respiratory infections, so bony alterations in cases of heart conditions may be due to respiratory illness. Since respiratory infection remains a leading cause of mortality today, CO and PH in bioarchaeological contexts should be considered as potential indicators of respiratory infections in the past.

show abstract

“…During dissemination, bone and joint involvement is reported in less than half of cases and patients can present with osteomyelitis and lytic lesions, mostly of the thoracic and lumbar region with or without pulmonary manifestations 4 6 9. MRI is more sensitive than CT scan; however, PET/CT scan does show increased fluorodeoxyglucose activity in disseminated cases 8 14. To confirm the diagnosis, a biopsy is necessary to exclude other aetiologies such as malignancy, lymphoma or tuberculosis 6 14…”

Section: Discussionmentioning

confidence: 99%

“…MRI is more sensitive than CT scan; however, PET/CT scan does show increased fluorodeoxyglucose activity in disseminated cases 8 14. To confirm the diagnosis, a biopsy is necessary to exclude other aetiologies such as malignancy, lymphoma or tuberculosis 6 14…”

Section: Discussionmentioning

confidence: 99%

(Ig)Easy diagnosis of disseminated coccidioidomycosis

et al. 2022

View full text Add to dashboard Cite

An immunocompetent man in his 20s came to the hospital for shortness of breath, fevers and lower back pain with unintentional 20 lbs. weight loss. Relevant history included a recent trip to Arizona 3 months prior to presentation. On arrival, he was noted to have decreased breath sounds bilaterally, and paraspinal tenderness in the lumbar area. CT scan revealed diffuse pneumonitis and an abscess with osteomyelitis in the sacrum and right iliac bone. Continued respiratory decompensation led him to the intensive care unit where he had a bronchoscopy and later sacroiliac joint fluid collection was performed. Based on his travel history, and elevated serum IgE, liposomal amphotericin B was initiated. Later his antibodies against Coccidiodes resulted elevated and fungal cultures from the bronchoalveolar lavage and abscess from the sacral vertebrae grew mould, morphologically consistent with Coccidiodes posadasii. He was transitioned to oral fluconazole and will have a close follow-up outpatient.

show abstract

Disseminated coccidioidomycosis masquerading as recurrent lymphoma

Cited by 8 publications

References 3 publications

Indicators of stress and their association with frailty in the precontact Southwestern United States

Indicators of stress and their association with frailty in the precontact Southwestern United States

Cribra orbitalia and porotic hyperostosis are associated with respiratory infections in a contemporary mortality sample from New Mexico

(Ig)Easy diagnosis of disseminated coccidioidomycosis

Contact Info

Product

Resources

About