Disseminated cryptococcosis and histoplasmosis co-infection in a HIV-infected woman in France

Ferry, Tristan; Ponceau, B.; Gaultier, J.-B.; Piens, Marie‐Antoinette; Biron, F.; Picot, Stéphane; Chidiac, Christian; Peyramond, D.

doi:10.1016/j.jinf.2004.12.017

Cited by 12 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A PubMed search for the words Hc , Cn and co-infection renders many hits 9 10 11 12 13 14 15 16 17 18 19 20 21 , including multi-center reports of several patients 9 15 20 , with the first co-infection observation reported by Mider et al in 1947 16 . The diagnoses of co-infection was made by either histological examination and/or cultures of various tissues and body fluids.…”

Section: Discussionmentioning

confidence: 99%

“…acquisition occurring concomitantly or separately). Nevertheless, a review of the literature finds a significant number of cases of Cn-Hc co-infections 9 10 11 12 13 14 15 16 17 18 19 20 21 , which establishes that co-infections can and do occur, and can progress to disease with both fungi. Identification of co-infected individuals is complicated by the fact that clinical manifestations of both mycoses and the antifungal therapy administered for them are similar (typically a polyene followed by an azole).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection

Cordero

Liedke

Araújo

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Cryptococcus neoformans (Cn) and Histoplasma capsulatum (Hc) co-exist in the environment and occasionally co-infect individuals, which can lead to severe disease/lethal outcomes. We investigated specific interactions between Cn-Hc to determine the impact of synchronous infection in virulence and disease. Co-infected mice had significantly higher mortality than infection with either species or acapsular Cn-Hc. Coating of Hc with cryptococcal glycans (Cn-gly) resulted in higher pulmonary fungal burden in co-infected animals relative to control. Co-cultivation or addition of Cn-gly resulted in enhanced pellicle formation with a hybrid polysaccharide matrix with higher reactivity to GXM mAbs. Transfer and incorporation of Cn polysaccharide onto Hc surface was time and temperature dependent. Cn-gly transfer altered the zeta potential of Hc and was associated with increased resistance to phagocytosis and killing by macrophages. Mice infected with Hc and subsequently injected with purified Cn-gly died significantly more rapidly than Hc alone infected, establishing the precedent that virulence factors from one fungus can enhance the virulence of unrelated species. These findings suggest a new mechanism of microbial interaction involving the transfer of virulence traits that translates into enhanced lethality during mixed fungal infections and highlights the importance of studying heterogeneous microbial populations in the setting of infection.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection

Cordero

Liedke

Araújo

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The fact that our patient's chest imaging was more consistent with cryptococcal pneumonia than DH and the failure of BAL fluid to yield H. capsulatum suggest the possibility of dissemination arising from an extrapulmonary site without any overt lung involvement. Interestingly, in an analogous co-infection case reported from France, respiratory fungal culture was positive for C. neoformans but negative for H. capsulatum despite unequivocal evidence of DH [24] .…”

Section: Discussionmentioning

confidence: 87%

Update on the spectrum of histoplasmosis among hispanic patients presenting to a New York City municipal hospital: A contemporary case series

Gandhi

Ulyanovskiy

Epelbaum

2015

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

Histoplasma capsulatum is the most common endemic mycosis worldwide. Although most of the globe's largest urban hubs fall outside this organism's regions of endemicity, clinicians practicing in a metropolis like New York City or Los Angeles must nevertheless remain vigilant for histoplasmosis because of the large immigrant population that is served by its hospitals. H. capsulatum infection ranges from asymptomatic pulmonary infection to life-threatening diffuse pneumonia with dissemination. The early years of the AIDS epidemic first introduced U.S. clinicians working in areas previously unfamiliar with histoplasmosis to newly immunocompromised patients from endemic regions presenting with disseminated H. capsulatum originally acquired in their home countries. Improvement in HIV prevention and therapeutics has reduced the frequency of such cases. Herein we report three cases of histoplasmosis encountered in our New York City institution over the last three years to emphasize that awareness of this infection remains mandatory for the frontline urban clinician.

show abstract

“…Histoplasmosis and cryptococcosis are two of the fungal diseases with higher prevalence in immunocompromised patients, especially in those with advanced HIV infection and CD4 T lymphocyte cell (CD4) counts lower than 150 and 100 cells/mm3, respectively [7]. Clinical features of both mycoses are similar, presenting with fever, asthenia, adynamia, weight loss, cough, dyspnea, expectoration, diarrhea, lymphadenopathy, hepatomegaly and the beginning of symptoms is insidious [2,8]. Cutaneous lesions are more frequent in histoplasmosis and the involvement of central nervous system is more frequent in cryptococcosis [3,4].…”

Section: Discussionmentioning

confidence: 99%

“…Their incidence has been reduced in 20-25% since the introduction of highly active anti-retroviral therapy (HAART) more than two decades ago [1]. Histoplasmosis and cryptococcosis are major causes of morbimortality in immunocompromised patients due to HIV infection [2], with a global mortality of 37.2 and 81.8% respectively [1,3]. We report the case of a patient with HIV infection with a CD4 T lymphocyte cell (CD4) count of 2 cells/mm3, who presented concurrent infection of three opportunistic pathogens: Cryptococcosis, disseminated histoplasmosis and cryptosporidiosis.…”

Section: Introductionmentioning

confidence: 99%

Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report

et al. 2018

View full text Add to dashboard Cite

BackgroundThose infected by human immunodeficiency virus (HIV) have a higher risk of opportunistic infections. The risk is related to the level of immunosuppression. We report a case of a young male with the unusual scenario of three opportunistic infections occurring simultaneously: Cryptococcosis, Histoplasmosis and Cryptosporidiosis. Histoplasmosis and cryptococcosis are major causes of morbimortality in immunocompromised patients due to HIV infection.Case presentationWe report the case of a patient with HIV infection with a CD4 T lymphocyte cell (CD4) count of 2 cells/mm3, who presented with 6 months of diarrhea, non-productive dry cough, nocturnal diaphoresis, fever, weight loss, and a maculopapular rash. He had a concurrent infection with three opportunistic microorganisms: fungemia by cryptococcosis, disseminated histoplasmosis confirmed by detection of the antigen in urine and chronic diarrhea by cryptosporidiosis confirmed by direct observation in feces by modified Ziehl–Neelsen stain. The patient received antifungal treatment with a satisfactory outcome.ConclusionsThere are still regions where HIV detection programs are deficient thus facilitating occurrence of HIV infection cases in advanced stages of immunosuppression. A high level of suspicion of systemic mycoses and concurrent infection by several opportunistic pathogens is required in severely immunocompromised patients.

show abstract

Disseminated cryptococcosis and histoplasmosis co-infection in a HIV-infected woman in France

Cited by 12 publications

References 10 publications

Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection

Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection

Update on the spectrum of histoplasmosis among hispanic patients presenting to a New York City municipal hospital: A contemporary case series

Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report

Contact Info

Product

Resources

About