Disseminated Cryptococcosis in a Young Immunocompetent Male

Donald, Saurabh; Kakkar, Naveen; Loomba, Vikas

doi:10.1007/s12288-020-01271-2

Cited by 1 publication

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“…A retrospective series from 1992 to 1996 reviewed 1225 bone marrow specimens from HIV patients, and of 31 specimens positive for mycobacteria and fungi, only one marrow grew C. neoformans [15]. Sparse case reports have identifed cryptococcal bone marrow infltration in a young immunocompetent male [16], a patient with a new HIV diagnosis [17], and a patient with previously diagnosed HIV 8 years prior who presented with a CD4 lymphocyte count of 26 cells/μL [18]. Despite the relative frequency of concomitant cryptococcal and HIV infections, cryptococcal bone marrow infltration remains rarely reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Haematologic and Urologic Manifestations of Cryptococcus neoformans

Morgan,

Vardanega,

Yue

et al. 2024

Case Reports in Infectious Diseases

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Cryptococcus neoformans classically causes pulmonary and central nervous system (CNS) infection in immunocompromised hosts and can lead to disseminated disease. Two cases of atypical cryptococcal infection are presented—an elderly Human Immunodeficiency Virus- (HIV-) negative male with a urinary source of infection and a young HIV-positive male with bone marrow infiltration complicated by haemophagocytic lymphohistiocytosis (HLH). A literature review of systemic cryptococcal infections involving the genitourinary tract and bone marrow was performed. These cases highlight the importance of clinicians considering uncommon manifestations of cryptococcal disease.

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Section: Discussionmentioning

confidence: 99%