Disseminated cutaneous coccidioidomycosis in a liver transplant patient

Singh, Gaurav; Patel, Tejas; Hu, Shasa

doi:10.1016/j.jdcr.2015.05.005

Cited by 3 publications

(13 citation statements)

References 10 publications

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“…Twenty‐four cases of donor‐derived infection (DDI) due to endemic mycoses were identified (Table 1), from 18 publications reported through May 2023 6–23 . Of these, the majority (16 of 24; 66.7%) were coccidioidomycosis, 6–9,14–16,18–20,23 and there were also 7 (29.2%) cases of histoplasmosis, 10,12,13,17,21,22 and one case of talaromycosis 11 .…”

Section: Resultsmentioning

confidence: 99%

“…19 There was one recipient who had asymptomatic serologic conversion which was detected because of close surveillance due to a suspected transmission event. 9 Chest imaging was performed for nine patients, 6,9,14,15,[18][19][20] and findings were variable (Table 2).…”

Section: Coccidioidomycosismentioning

confidence: 99%

“…Twenty-four cases of donor-derived infection (DDI) due to endemic mycoses were identified (Table 1), from 18 publications reported through May 2023. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Of these, the majority (16 of 24; 66.7%) were coccidioidomycosis, [6][7][8][9][14][15][16][18][19][20]23 and there were also 7 (29.2%) cases of histoplasmosis, 10,12,13,17,21,22 and one case of talaromycosis. 11 We found no published reports of DDI due to blastomycosis or paracoccidioidomycosis in our comprehensive review.…”

Section: Reviewsmentioning

confidence: 99%

“…The most common clinical presentation of donor-derived coccidiodomycosis was fever (11/16; 68.7%). 6,9,14,18,20,23 Many patients had pulmonary symptoms (n = 6), which included dyspnea or hypoxia 6,15,20,23 and cough. 9 Others had non-specific symptoms such as headache (n = 2), anorexia, nausea, vomiting, or diarrhea (n = 3), or body aches including neck or shoulder pain (n = 3).…”

Section: Coccidioidomycosismentioning

confidence: 99%

“…Five recipients had cytopenia of one or more blood cell lineages. 6,9 Disseminated coccidiodomycosis was the most common clinical syndrome (12/16, 75%), 6,8,9,[14][15][16]18,23 while pulmonary infection was reported in two lung, 7,20 and one kidney transplant recipient. 19 There was one recipient who had asymptomatic serologic conversion which was detected because of close surveillance due to a suspected transmission event.…”

Section: Coccidioidomycosismentioning

confidence: 99%

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Donor‐derived endemic mycoses after solid organ transplantation: A review of reported cases

Abad,

Razonable

2023

Clinical Transplantation

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BackgroundDonor‐derived endemic mycoses are infrequently reported. We summarized the clinical characteristics and outcomes of these infections to provide guidance to transplant clinicians.MethodsMultiple databases were reviewed from inception through May 31, 2023 using endemic fungi as key words (e.g., Coccidioides, histoplasma, blastomyces, talaromyces, paracoccidioides). Only donor‐derived infections (DDI) were included.ResultsTwenty‐four cases of DDI were identified from 18 published reports; these included 16 coccidioidomycosis, seven histoplasmosis, and one talaromycosis. No cases of blastomycosis and paracoccidiodomycosis were published. The majority were male (17/24,70.8%). Half of the cases were probable (12/24, 50%), seven were possible (29.2%), and only five were proven DDI (20.8%). Donor‐derived coccidioidomycosis were observed in kidney (n = 11), lung (n = 6), liver (n = 3), heart (n = 2) and combined SOT recipients (1 KP, 1 KL) at a median time of .9 (range .2–35) months after transplantation. For histoplasmosis, the majority were kidney recipients (6 of 7 cases) at a median onset of 8 (range .4–48) months after transplantation. The single reported possible donor‐derived talaromycosis occurred in a man whose organ donor had at‐risk travel to Southeast Asia. Collectively, the majority of donors had high‐risk exposure to Coccidioides (9/11) or Histoplasma sp. (6/6). Most donor‐derived endemic mycoses were disseminated (18/24, 75%), and mortality was reported in almost half of recipients (11/24, 45.8%).ConclusionDonor‐derived endemic mycoses are often disseminated and are associated with high mortality. A detailed evaluation of donors for the potential of an undiagnosed fungal infection prior to organ donation is essential to mitigate the risk of these devastating infections.

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Section: Resultsmentioning

confidence: 99%

Section: Coccidioidomycosismentioning

confidence: 99%

Section: Reviewsmentioning

confidence: 99%

Section: Coccidioidomycosismentioning

confidence: 99%

Section: Coccidioidomycosismentioning

confidence: 99%

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Donor‐derived endemic mycoses after solid organ transplantation: A review of reported cases

Abad,

Razonable

2023

Clinical Transplantation

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Tacrolimus

2015

Reactions Weekly

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Clinical Characteristics and Outcomes of Endemic Mycoses After Solid Organ Transplantation: A Comprehensive Review

Abad,

Razonable

2024

Open Forum Infectious Diseases

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Background Geographically endemic fungi can cause significant disease among solid organ transplant (SOT) recipients. We provide an update on the epidemiology, clinical presentation and outcomes of 5 endemic mycoses in SOT recipients. Methods Multiple databases were reviewed from inception through May 2023 using key words for endemic fungi (e.g. Coccidioidomycosis or Coccidioides, Histoplasmosis or histoplasma, etc.). We included adult SOT recipients and publications in English or with English translation. Results Among 16 cohort studies that reported on blastomycosis (n=3), coccidioidomycosis (n=5), histoplasmosis (n=4), and various endemic mycoses (n=4), the incidence rates varied: coccidioidomycosis (1.2-5.8%); blastomycosis (0.14-0.99%) and histoplasmosis (0.4-1.1%). There were 204 reports that described 268 unique cases of endemic mycoses, including 172 histoplasmosis, 31 blastomycosis, 34 coccidioidomycosis, 6 paracoccidioidomycosis, and 25 talaromycosis. The majority of patients were male (176/261, 67.4%). Transplanted allografts were mostly kidney (191/268, 71.3%), followed by liver (n=39, 14.6%), heart (n=18, 6.7%), lung (n=13, 4.9%), combined kidney-liver, and kidney-pancreas (n=6, 2.7%). In all five endemic mycoses, most patients presented with fever (162/232, 69.8%) and disseminated disease (179/268, 66.8%). Cytopenias were frequently reported for histoplasmosis (71/91, 78.0%), coccidioidomycosis (8/11, 72.7%) and talaromycosis (7/8, 87.5%). Graft loss was reported in 12/136 patients (8.8%). All-cause mortality was reported in 71/267 (26.6%); half (n=34, 50%) of the deaths were related to the underlying mycoses. Conclusions Endemic mycoses commonly present with fever, cytopenias and disseminated disease in SOT recipients. There is a relatively high rate of all-cause mortality, including many that were attributed to endemic mycoses.

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Disseminated cutaneous coccidioidomycosis in a liver transplant patient

Abstract: openAccessArticle: Truecover date: 2015-07-01pii: S2352-5126(15)00094-6Harvest Date: 2016-01-06 13:08:31issueName:Page Range: 225-225href scidir: http://www.sciencedirect.com/science/article/pii/S2352512615000946pubType: Case serie

Cited by 3 publications

References 10 publications

Donor‐derived endemic mycoses after solid organ transplantation: A review of reported cases

Donor‐derived endemic mycoses after solid organ transplantation: A review of reported cases

Tacrolimus

Clinical Characteristics and Outcomes of Endemic Mycoses After Solid Organ Transplantation: A Comprehensive Review

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