Disseminated cutaneous histoplasmosis in acquired immunodeficiency syndrome: report of 23 cases

Abstract

Disseminated cutaneous histoplasmosis is an opportunistic infection in patients with acquired immunodeficiency syndrome. We report a series of 23 cases (21 men, two women; median age 29 years) with disseminated cutaneous histoplasmosis seen at two hospital centres. Most of the patients (21/23) were classified as stage C3. The most common dermatological findings were papules, crusting plaques, nodules and ulcers, mainly located on the face and chest. Of the 23 cases, 15 (65%) had pulmonary involvement. Amphotericin B and itraconazole were the main drugs used for treatment. Treatment response was variable: four of the patients were cured, six improved and remain stable, nine patients died, and four patients were lost to follow-up.

Histoplasmosis en Colombia: resultados de la encuesta nacional, 1992-2008

“…This finding agrees with the pattern of AIDS distribution in the Colombian population (36). Such a tendency has been reported in other series as well (2,3,7,(17)(18)(19)23).…”

“…In the 417 adult patients, diagnosis by culturing H. capsulatum was done in 58%, by microscopic observation in 49.6% and by serological test in 14.6%. For each of the four groups analyzed, namely, States, this mycosis also occurs frequently in most Central and South American countries, Mexico (16,17), Panama (18), Venezuela (19,20) French Guyana (21), Brazil (22)(23)(24)(25)(26), and Argentina (27,28).…”

Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome: case report and literature review

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Although rare, patients with AIDS and skin lesions but without lung involvement have also been reported recently. [5][6][7][8] Furthermore, an unusual orofacial case of manifestations of histoplasmosis in immunocompromised renal transplanted patient has also been described. 10 Therefore, our objective in presenting this case was to draw attention to the diagnosis of histoplasmosis among patients with skin lesions alone, in the absence of pulmonary involvement, because such cases can also evolve very rapidly to systemic infection, multiple organ failure and death, especially among patients with AIDS.…”

“…10 Therefore, our objective in presenting this case was to draw attention to the diagnosis of histoplasmosis among patients with skin lesions alone, in the absence of pulmonary involvement, because such cases can also evolve very rapidly to systemic infection, multiple organ failure and death, especially among patients with AIDS. [2][3][4][5][6][7] We performed a search in the relevant databases (Cochrane Database of Systematic Reviews; Embase Biomedical Answers; Literatura Latino-Americana e do Caribe em Ciências da Saúde; and United States National Library of Medicine and National Institutes of Health) for nasal septum and histoplasmosis, and the results are presented in Table 1.…”

The impact of human immunodeficiency virus-related diseases on pigmented skin types

“…Several of these opportunistic fungal infections are geographically restricted and therefore a history of previous travel to endemic regions is important. [24][25][26] In contrast, sporotrichosis is endemic worldwide. In HIV-infected persons sporotrichosis may disseminate haematogenously from a pulmonary focus of infection producing multiple widespread subcutaneous nodules and cutaneous ulcers.…”