2010
DOI: 10.1111/j.1525-1470.2010.01273.x
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Disseminated Cutaneous Histoplasmosis in an Immunocompetent Child, Relapsed with Itraconazole, Successfully Treated with Voriconazole

Abstract: We present a rare case of disseminated cutaneous histoplasmosis in an immunocompetent child who relapsed after treatment with amphotericin B followed by itraconazole and was successfully treated with voriconazole.

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Cited by 21 publications
(5 citation statements)
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“…Most cases of disseminated histoplasmosis occurred in persons with compromised immunity ( Table 2 ) [ 21 , 22 ]. These infections are also common at the extremes of age, i.e., in infants and the elderly, although cases of disseminated histoplasmosis have been reported in apparently normal individuals without the usual risk factors of extremes of age or some form of immunosuppression [ 23 , 24 ]. Childhood cancers such as leukemias and lymphomas as well as their treatment may predispose to histoplasmosis [ 21 ].…”
Section: Resultsmentioning
confidence: 99%
“…Most cases of disseminated histoplasmosis occurred in persons with compromised immunity ( Table 2 ) [ 21 , 22 ]. These infections are also common at the extremes of age, i.e., in infants and the elderly, although cases of disseminated histoplasmosis have been reported in apparently normal individuals without the usual risk factors of extremes of age or some form of immunosuppression [ 23 , 24 ]. Childhood cancers such as leukemias and lymphomas as well as their treatment may predispose to histoplasmosis [ 21 ].…”
Section: Resultsmentioning
confidence: 99%
“…It also occurs in immunocompetent individuals and frequently presents as an asymptomatic or self-limited influenza-like process. In several reported cases, serious extrapulmonary injury occurred in groups of children [3,4], or patients with underlying diseases [5,6]. Infection occurs by inhalation of fungal spores and results in a variety of clinical manifestations including acute pulmonary histoplasmosis, chronic pulmonary histoplasmosis or disseminated histoplasmosis [7].…”
Section: Discussionmentioning
confidence: 99%
“…Itraconazole is the preferred choice for treatment of mild to moderate histoplasmosis [19]. Voriconazole, for the treatment of relapse after initial therapy with itraconazole [4] is another treatment option. In the current study, we used amphotericin B deoxycholate to treat the patient.…”
Section: Discussionmentioning
confidence: 99%
“…The patient in this study was a 46-year-old-diabetic male and a resident of Delhi in North India. Delhi has previously not been considered endemic but some cases have been reported recently [12][13][14]. Disseminated histoplasmosis develops mostly in patients who are immunocompromised.…”
Section: Discussionmentioning
confidence: 99%