Disseminated cutaneous leishmaniasis, an emerging form of cutaneous leishmaniasis: report of two cases

Ogawa, Marília Marufuji; Ruete, Lara Casseb; Michalany, Nílceo Schwery; Tomimori‐Yamashita, Jane

doi:10.1111/j.1365-4632.2006.02712.x

Cited by 4 publications

(1 citation statement)

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“…It has also been observed in other regions of Brazil and South America [Galvão et al, 1993;Ogawa et al, 2006;Calvopina et al, 2005]. DL has also been reported in the Old World [Alborzi et al, 2008]; some cases are associated with immunosuppression [Agostini et al, 1998;Schraner et al, 2005;Lindoso et al, 2009].…”

Section: Introductionmentioning

confidence: 76%

Disseminated Leishmaniasis: Clinical, immunological, and therapeutic aspects

Rosa

Machado

2011

Drug Development Research

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Disseminated leishmaniasis (DL) is a distinct, severe, and emerging form of American tegumentary leishmaniasis. DL has been characterized by more than 10 multiple and pleomorphic cutaneous lesions, distributed in more than two noncontiguous parts of the body. Mucosal involvement is detected in up to 44% of cases. The development of the DL involves a complex and poorly understood network involving parasite, host immune response, and the environment, where L. braziliensis polymorphism plays a major role. A decrease in the type 1 immune response in the peripheral blood of DL patients appears to be caused by the attraction of Leishmania-activated T cells to the multiple cutaneous lesions. DL is a difficult to cure disease and failure to pentavalent antimony therapy is observed in at least 60% of cases. Drug Dev Res 72:437-441, 2011.

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