Disseminated dermal <i>Trichophyton rubrum</i> infection – an expression of dermatophyte dimorphism?

Lillis, Joseph V.; Dawson, Elizabeth S.; Chang, Renee; White, Clifton R.

doi:10.1111/j.1600-0560.2009.01355.x

Cited by 17 publications

(21 citation statements)

References 9 publications

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“…Nevertheless, the extract showed an unprecedented potent antifungal activity against two of important human fungal pathogens namely, T. rubrum [18] and A. terreus [19] at concentrations (700 mg/ml) and (500, 700 mg/ml) respectively (Table 3 ). The extract under these two concentrations showed clear zone of inhibition.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Growth of Highly Resistant Bacterial and Fungal Pathogens by a Natural Product

Hafidh

Abdulamir²,

Vern³

et al. 2011

TOMICROJ

137

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The continuous escalation of resistant bacteria against a wide range of antibiotics necessitates discovering novel unconventional sources of antibiotics. B. oleracea L (red cabbage) is health-promoting food with proven anticancer and anti-inflammatory activities. However, it has not been researched adequately for its antimicrobial activity on potential resistant pathogens. The methanol crude extract of B. oleracea L. was investigated for a possible anti-microbial activity. The screening method was conducted using disc diffusion assay against 22 pathogenic bacteria and fungi. It was followed by evaluation of the minimum inhibitory concentration (MIC). Moreover, the antibacterial and the antifungal activities were confirmed using the minimum bactericidal concentration (MBC) and the minimum fungicidal concentration (MFC), respectively. Remarkable, antibacterial activity was evident particularly against highly infectious microorganisms such as Methicillin-resistant Staphylococcus aureus, Escherichia coli O157:H7, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Salmonella enterica serovar Typhimurium as well as against human fungal pathogens, Trichophyton rubrum and Aspergillus terreus. Red cabbage is a rich source of phenolic compounds, anthocyanins being the most abundant class, which might explain its potent antimicrobial action. This extract is potentially novel for future antimicrobials, inexpensive, and readily available at a large scale for pharmaceutical companies for further investigation and processing.

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Section: Resultsmentioning

confidence: 99%

Inhibition of Growth of Highly Resistant Bacterial and Fungal Pathogens by a Natural Product

Hafidh

Abdulamir²,

Vern³

et al. 2011

TOMICROJ

137

View full text Add to dashboard Cite

show abstract

“…However, during invasive or deep dermal infections, dermatophytes also manifest morphological diversity as broad, pleomorphic hyphae with budding yeast -like arthrospores are observed (King et al 1975;Bibel et al 1977;Lillis et al 2010;Marconi et al 2010;Brand 2012). Such morphological switching in the dermatophyte Trichophyton mentagrophytes can also be observed under certain in vitro conditions (Bibel et al 1977).…”

Section: Morphotype Niche Adaptation and Fungal Virulencementioning

confidence: 86%

Fungal Morphogenesis

Lin

Alspaugh

Liu

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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Morphogenesis in fungi is often induced by extracellular factors and executed by fungal genetic factors. Cell surface changes and alterations of the microenvironment often accompany morphogenetic changes in fungi. In this review, we will first discuss the general traits of yeast and hyphal morphotypes and how morphogenesis affects development and adaptation by fungi to their native niches, including host niches. Then we will focus on the molecular machinery responsible for the two most fundamental growth forms, yeast and hyphae. Last, we will describe how fungi incorporate exogenous environmental and host signals together with genetic factors to determine their morphotype and how morphogenesis, in turn, shapes the fungal microenvironment. PROPERTIES OF MORPHOGENESIS IN FUNGAL CELLS

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“…Although Cryptococcus neoformans is not considered to be a dimorphic fungus, this species has a unique property of forming "giant," or "titan," cells in the host. Further studies have also described morphotypeassociated pathogenicity among certain Zygomycota and dermatophyte species (36,37).…”

Section: Dimorphism Is Widespread Among Fungimentioning

confidence: 99%

Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases

et al. 2017

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The fungal lineage is one of the three large eukaryotic lineages that dominate terrestrial ecosystems. They share a common ancestor with animals in the eukaryotic supergroup Opisthokonta and have a deeper common ancestry with plants, yet several phenotypes, such as morphological, physiological, or nutritional traits, make them unique among all living organisms. This article provides an overview of some of the most important fungal traits, how they evolve, and what major genes and gene families contribute to their development. The traits highlighted here represent just a sample of the characteristics that have evolved in fungi, including polarized multicellular growth, fruiting body development, dimorphism, secondary metabolism, wood decay, and mycorrhizae. However, a great number of other important traits also underlie the evolution of the taxonomically and phenotypically hyperdiverse fungal kingdom, which could fill up a volume on its own. After reviewing the evolution of these six well-studied traits in fungi, we discuss how the recurrent evolution of phenotypic similarity, that is, convergent evolution in the broad sense, has shaped their phylogenetic distribution in extant species.

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Disseminated dermal Trichophyton rubrum infection – an expression of dermatophyte dimorphism?

Cited by 17 publications

References 9 publications

Inhibition of Growth of Highly Resistant Bacterial and Fungal Pathogens by a Natural Product

Inhibition of Growth of Highly Resistant Bacterial and Fungal Pathogens by a Natural Product

Fungal Morphogenesis

Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases

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