Disseminated discoid lupus erythematosus leading to squamous cell carcinoma

Bhat, M Ramesh; Hulmani, Manjunath; Sukumar, D; Kambil, Srinath M; Gatti, Rohan C

doi:10.4103/0019-5154.94298

Cited by 14 publications

(16 citation statements)

References 3 publications

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“…[3][4][5] But in contrast, Tao et al found more patients of localized DLE developing SCC which is similar to our case report. 6 In a review by Sherman et al, the interval between development of DLE and SCC has varied from 4-20 years.…”

Section: Discussioncontrasting

confidence: 52%

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Discoid lupus erythematosus leading to squamous cell carcinoma: a case report

Dadapeer

Sushma

2017

Int J Res Dermatol

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Discoid lupus erythematosus (DLE) is the most common chronic form of cutaneous lupus. It is characterised by persistent scaly, disk-like plaques on scalp, face and ears that may cause pigmentary changes, scarring and hair loss. Squamous cell carcinoma can rarely arise within a longstanding DLE plaque in the skin. It presents as an enlarging warty growth or ulcer. We report a case of squamous cell carcinoma which developed on lesion of discoid lupus erythematosus within a short period of time.

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Section: Discussioncontrasting

confidence: 52%

“…5,8 The lips were the most commonly affected area in DLE related SCC. We are reporting a case of SCC over DLE presenting over external ear.…”

Section: Discussionmentioning

confidence: 99%

Discoid lupus erythematosus leading to squamous cell carcinoma: a case report

Dadapeer

Sushma

2017

Int J Res Dermatol

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“…Precipitating factors of SCC are (a) age more than 40 years, (b) male sex with early onset DLE, (c) exposure to ultraviolet rays, (d) chronic inflammatory processes with scarring and (e) patients resistant to treatment. (6) In the present case, the SCC developed in a DLE plaque after 2 years which is quite early. The early onset of this malignancy may be attributed to the age (i.e.…”

Section: Discussionsupporting

confidence: 45%

Mutilating Squamous Cell Carcinoma: A Rare Complication of an Early Plaque of Discoid Lupus Erythematosus

Kaur¹,

Sahu²,

Dayal³

et al. 2016

West Indian Med J

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Cutaneous Squamous cell carcinoma (SCC) is the second most common form of nonmelanotic skin cancer after basal cell carcinoma (BCC). It is a well-known complication of DLE and usually favours the depigmented lesions located over sun-exposed areas. The clinical course of this complication may be aggressive, with a high risk of mortality. Literature describes numerous case reports of SCC complicating the lesions of DLE but mutilating SCC is rarely mentioned. Here in, we report a rare case of mutilating squamous cell carcinoma arising in an early (2 years duration) lesion of DLE.

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“…Вместе с тем в доступных литературных источниках встречаются, как правило, описания случаев или серии случаев рака кожи у больных, уже имеющих волчаночное поражение кожи в виде дискоидной или подострой кожной волчанки. По данным ряда авторов плоскоклеточный рак кожи, возникающий у пациентов с дискоидной красной волчанкой, имеет более агрессивное течение с повышенной частотой рецидивов, метастазирования и смертности, по сравнению с другими формами рака кожи [4]. Интервал между дебютом волчанки и плоскоклеточным раком кожи варьирует обычно от 4 до 20 лет [4].…”

Section: Discussionunclassified

Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review

Тополянская

2020

Arhivʺ vnutrennej mediciny

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The case report of squamous cell skin carcinoma diagnosed in a patient with systemic lupus erythematosus 26 years after the onset of rheumatic disease is presented. The features of this case included the absence of skin manifestations of systemic lupus erythematosus, the occurrence of a tumor at the site of ulcers and trophic disorders on the leg, a long period (6 years) from the onset of a ulcerative defect on the leg to the diagnosis of skin cancer (despite multiple biopsies and consultations of various specialists), as well as the occurrence of a cytokine release syndrome, which directly led to the death of the patient after the first use of the immune checkpoint inhibitors. Possible causes of skin cancer in patients with systemic lupus erythematosus, as well as the features of the cytokine release syndrome after immunotherapy for oncological diseases, are discussed.

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Disseminated discoid lupus erythematosus leading to squamous cell carcinoma

Cited by 14 publications

References 3 publications

Discoid lupus erythematosus leading to squamous cell carcinoma: a case report

Discoid lupus erythematosus leading to squamous cell carcinoma: a case report

Mutilating Squamous Cell Carcinoma: A Rare Complication of an Early Plaque of Discoid Lupus Erythematosus

Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review

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