Disseminated Eruptive Giant Mollusca Contagiosa in an Adult Psoriasis Patient during Efalizumab Therapy

Weisenseel, Peter; Kuznetsov, Alexander Vasilevic; Flaig, Michael J.; Prinz, Jörg C.

doi:10.1159/000128282

Cited by 15 publications

(10 citation statements)

References 12 publications

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“…The typical appearance of multiple discrete skin‐colored umbilicated papules is easily recognizable. Disseminated lesions may be seen in patients receiving systemic immunosuppression 1 and can localize to skin receiving topical immunosuppressive medication 2 . In patients with HIV, widespread lesions and more unusual presentations, including a cheek abscess, have been reported 3 …”

Section: Discussionmentioning

confidence: 99%

Verrucous plaques in a pemphigus vulgaris patient on immunosuppressive therapy

2012

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Section: Discussionmentioning

confidence: 99%

Verrucous plaques in a pemphigus vulgaris patient on immunosuppressive therapy

2012

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“…The occurrence of multiple MCs during treatment with PSL, MTX, and biologics has been reported [1][2][3][4][5][6], and a few cases of multiple MCs in patients with RA have also been seen [5,6]. A number of studies have shown immunologic dysfunction in RA.…”

Section: Discussionmentioning

confidence: 99%

Eruptive molluscum contagiosums in a patient with rheumatoid arthritis and lung cancer

et al. 2010

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A 67-year-old woman with rheumatoid arthritis (RA) treated with systemic prednisolone and methotrexate over 20 years developed eruptive molluscum contagiosums on the trunk and extremities. Investigation revealed lung cancer 2 years later. Newly development of molluscum contagiosums ceased after the surgical operation of lung cancer. Immunologic dysfunctions have been shown in RA, and especially patients under long-term methotrexate therapy are susceptible to miscellaneous skin conditions. Eruptive molluscum contagiosums are induced in association with hematologic malignancies such as lymphoma, leukemia, and HIV infection; however, it is important to investigate internal malignancies, not only hematologic malignancies but also solid cancers, when patients with RA under immunosuppressive therapies presented eruptive or disseminated molluscum contagiosums.

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“…However, in the postmarketing surveillance different and severe cases of opportunistic infections have been reported including sporadic case reports of visceral leishmaniasis, disseminated eruptive giant molluscum contagiosum, cytomegalovirus colitis and fatal cases of progressive multifocal leukoencephalopathy [36,37,38,39,40]. At the time this paper was resubmitted, the European Medicines Agency recommended withdrawal of the marketing authorization for efalizumab as the risks outweighed its benefits [40].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Psoriasis with Efalizumab in Patients with Hepatitis C Viral Infection: Report of Five Cases

Gisondi

Prignano²,

Grossi³

et al. 2009

Dermatology

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Background: Concomitant hepatitis C virus infection (HCV) needs caution when selecting systemic treatments in psoriasis patients as some agents confer a risk of liver toxicity and/or are immunosuppressant. Phototherapy may provide a therapeutic choice but it is not always a practical option. Limited evidence supports the use of cyclosporine or TNF-α blockers. No data are available concerning the safety of efalizumab in patients with HCV infection. Objective: To describe the clinical characteristics and evolution of 5 adult patients with severe chronic plaque psoriasis and concomitant HCV infection who were treated with efalizumab. Method: A retrospective clinical case report. Results: Five adult patients with severe chronic plaque psoriasis and concomitant HCV infection were treated successfully using efalizumab with no increased viral replication and progression of liver disease for a follow-up of 8–20 months. Conclusion: Although further confirmation is needed, this report provides preliminary evidence to support also a cautious use of efalizumab in patients with HCV infection.

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Disseminated Eruptive Giant Mollusca Contagiosa in an Adult Psoriasis Patient during Efalizumab Therapy

Abstract: Molluscum contagiosum is a common viral skin infection in children with atopic diathesis and not rare in HIV patients. We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.

Cited by 15 publications

References 12 publications

Verrucous plaques in a pemphigus vulgaris patient on immunosuppressive therapy

Verrucous plaques in a pemphigus vulgaris patient on immunosuppressive therapy

Eruptive molluscum contagiosums in a patient with rheumatoid arthritis and lung cancer

Treatment of Psoriasis with Efalizumab in Patients with Hepatitis C Viral Infection: Report of Five Cases

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