Disseminated fusariosis and hematologic malignancies, a still devastating association. Report of three new cases

García‐Ruiz, Juan Carlos; Olazábal, Iñigo; Pedroso, Rosa María Adán; López-Soria, Leyre; Velasco-Benito, Verónica; Sánchez-Aparicio, José Antonio; Navajas, Aurora; Montejo, Miguel; Moragues, Marı́a D.

doi:10.1016/j.riam.2014.11.003

Cited by 12 publications

(10 citation statements)

References 55 publications

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“…ungi of the genus Fusarium are primarily plant pathogens and saprobes that cause a broad spectrum of infections in humans; including superficial, local, invasive, and disseminated infections, in immunologically deficient humans (1). After aspergillosis, disseminated fusariosis is the second most common cause of invasive infection by filamentous fungi in patients with hematologic malignancies or those undergoing transplants of hematopoietic progenitors; its high mortality rate and the lack of an optimal management protocol have raised increasing interest in this mycosis (2).…”

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confidence: 99%

In vitro antifungal susceptibility of clinical isolates of Fusarium from Colombia

2017

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confidence: 99%

In vitro antifungal susceptibility of clinical isolates of Fusarium from Colombia

2017

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“…The dermatological examination also showed livedo reticularis in the entire lower limb reaching the abdomen, which probably occurred due to intravascular proliferation of the fungus leading to occlusion and necrosis of the microvasculature, although the authors have not found any reports of this phenomenon in the literature. 5 , 8 , 9 …”

Section: Discussionmentioning

confidence: 99%

Disseminated fusariosis in a patient with bone marrow aplasia

Chagas¹,

Diniz²,

Lucas³

et al. 2020

Anais Brasileiros de Dermatologia

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Fusariosis is a superficial or systemic infection, which occurs mainly in immunocompromised hosts, especially in patients with hematological neoplasia; 70%–75% of the cases present cutaneous manifestations. The disseminated form is rare and difficult to diagnose; even with specific treatment, the evolution is usually fatal. Currently, it is considered an emerging disease; in some centers, it is the second most common cause of invasive mycosis, after aspergillosis. The authors describe a case of a female patient with idiopathic bone marrow aplasia and disseminated fusariosis, who initially appeared to benefit from voriconazole and amphotericin B; however, due to persistent neutropenia, her clinical condition deteriorated with fatal evolution.

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“… 2 Some authors recommend combination therapy, such as voriconazole with liposomal amphotericin B, but more studies are needed to explore the real benefit of combination treatment. 8 , 10 …”

Section: Discussionmentioning

confidence: 99%

“… 8 Preventing the dissemination of infection in colonized patients, early diagnosis, and the prolonged use of a combination of antifungals are essential to decrease the mortality rate of this severe infection. 10 …”

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confidence: 99%

Disseminated fusariosis with cutaneous involvement in hematologic malignancies: report of six cases with high mortality rate

Hayashida

Seque

Enokihara

et al. 2018

An. Bras. Dermatol.

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Fusariosis is due to inhalation or direct contact with conidia. Clinical presentation depends on host's immunity and can be localized, focally invasive or disseminated. Given the severity of this infection and the possibility for the dermatologist to make an early diagnosis, we report six cases of patients with hematologic malignancies, who developed febrile neutropenia an skin lesions suggestive of cutaneous fusariosis. All patients had skin cultures showing growth of Fusarium solani complex, and they received amphotericin B and voriconazole. As this infection can quickly lead to death, dermatologists play a crucial role in diagnosing this disease.

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Disseminated fusariosis and hematologic malignancies, a still devastating association. Report of three new cases

Cited by 12 publications

References 55 publications

In vitro antifungal susceptibility of clinical isolates of Fusarium from Colombia

In vitro antifungal susceptibility of clinical isolates of Fusarium from Colombia

Disseminated fusariosis in a patient with bone marrow aplasia

Disseminated fusariosis with cutaneous involvement in hematologic malignancies: report of six cases with high mortality rate

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