Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): II. Clinical manifestations, diagnosis, complications, treatment, and prevention

Masi, Alfonse T.; Eisenstein, Barry I.

doi:10.1016/s0049-0172(81)80002-9

Cited by 84 publications

(42 citation statements)

References 87 publications

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“…[34][35][36][37] Symptoms, when present, include increased vaginal discharge, dysuria, intermenstrual bleeding, and hypermenorrhea, with the most common local complication being acute salpingitis or pelvic inflammatory disease. Gonococcal perihepatitis (FitzHugh-Curtis syndrome) can imitate acute cholecystitis 8 and lead to misdiagnosis with failure to provide appropriate treatment.…”

Section: Genital Discharge Diseases: Gonorrhea Chlamydia and Trichomentioning

confidence: 99%

Sex Differences in the Transmission, Prevention, and Disease Manifestations of Sexually Transmitted Diseases

Madkan

Giancola²,

Karan³

et al. 2006

Arch Dermatol

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Section: Genital Discharge Diseases: Gonorrhea Chlamydia and Trichomentioning

confidence: 99%

Sex Differences in the Transmission, Prevention, and Disease Manifestations of Sexually Transmitted Diseases

Madkan

Giancola²,

Karan³

et al. 2006

Arch Dermatol

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“…PGCT induces the production of the inflammatory cytokines interleukin-1 (IL-1) and IL-6 in cultured cells and induces arthritis in a rat model (6,8,15). Arthropathic effects are characteristic of disseminated gonococcal infection (23). The sloughing of the majority of ciliated cells and the disruption of the mucosal integrity by application of purified PG monomers mimic the effects of gonococcal infection in the fallopian tube organ culture model of pelvic inflammatory disease (24).…”

mentioning

confidence: 99%

A Lytic Transglycosylase of Neisseria gonorrhoeae Is Involved in Peptidoglycan-Derived Cytotoxin Production

Cloud

Dillard

2002

Infect Immun

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Neisseria gonorrhoeae releases soluble fragments of peptidoglycan during growth. These molecules are implicated in the pathogenesis of various forms of gonococcal infection. A major peptidoglycan fragment released by gonococci is identical to the tracheal cytotoxin of Bordetella pertussis and has been shown to kill ciliated fallopian tube cells in organ culture. Previous studies indicated that a unique lytic peptidoglycan transglycosylase (AtlA) was responsible for some, but not all, of the peptidoglycan-derived cytotoxin (PGCT) production in certain gonococcal strains. To examine the role of other putative lytic transglycosylases in PGCT production, we made a deletion mutation in a gonococcal gene exhibiting similarity with genes encoding lytic transglycosylases from other bacterial species. The gonococcal mutant was viable and grew normally, but it was less autolytic than the wild-type strain in stationary-phase culture and under nongrowth conditions. The gonococcal mutant was reduced in peptidoglycan turnover, and the profile of the released products showed a reduction in monomeric peptidoglycan. Proportionally more multimeric fragments were released. These results suggest that this gonococcal gene (ltgA) encodes a lytic peptidoglycan transglycosylase and that it is responsible for a significant proportion of the PGCT released by N. gonorrhoeae.

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“…Classiquement, les infections disséminées à gonocoque associent la triade clinique : arthrites, rash cutané et ténosynovites. Les arthrites sont localisées préférentiellement au niveau des genoux, coudes, poignets et chevilles [9,13]. Les atteintes des hanches et sternoclaviculaires sont rares et se voient chez le patient VIH [8,10].…”

Section: Discussionunclassified

“…La bactérie Neisseria gonorrhoeae est un germe Gram négatif à développement intracellulaire. Sa virulence dépend de l'hôte (baisse de l'immunité, facteurs hormonaux) et de son architecture, notamment sa composition membranaire (antigène, lipo-oligosaccharide) [9,13]. À propos du traitement, une intervention chirurgicale pour drainage de la gaine est nécessaire et est retrouvée dans tous les cas.…”

Section: Discussionunclassified

Ténosynovite isolée à gonocoque, à propos d’un cas et revue de la littérature

Mamane

Falcone

Doursounian

et al. 2010

Chirurgie de la Main

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Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): II. Clinical manifestations, diagnosis, complications, treatment, and prevention

Cited by 84 publications

References 87 publications

Sex Differences in the Transmission, Prevention, and Disease Manifestations of Sexually Transmitted Diseases

Sex Differences in the Transmission, Prevention, and Disease Manifestations of Sexually Transmitted Diseases

A Lytic Transglycosylase of Neisseria gonorrhoeae Is Involved in Peptidoglycan-Derived Cytotoxin Production

Ténosynovite isolée à gonocoque, à propos d’un cas et revue de la littérature

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