Disseminated histiocytic sarcoma in a Labrador retriever in Brazil

Gonçalves, Saulo Romero Felix; Barretto, Mariana Lumack do Monte; Silva, Débora; Albuquerque, Pedro; Barros, Alessandra Santana Soares e; Bezerra, Letícia; Filho, A. Martins; Santos, E. Burck Dos; Oliveira, Aline Feitoza de; Souza, Francisco de Assis Leite

doi:10.24070/bjvp.1983-0246.v12i3p134-138

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…HS can present in a localized or disseminated form; the disseminated form affects different sites (12). Sites frequently affected are spleen, lung, lymph nodes, bone marrow, skin, subcutaneous tissue, liver, periarticular and articular tissues.…”

Section: Introductionmentioning

confidence: 99%

Concomitant occurrence of multicentric hemangiosarcoma and histiocytic sarcoma in a dog

Gouveia¹,

Perossi²,

Silva³

et al. 2023

BJVP

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Histiocytic sarcoma (HS) is uncommon malignant neoplasia of round cells with marked predilection in Rottweiler and Bernese Mountain. The disseminated form, which mainly affects the spleen, lungs, lymph nodes, bone marrow, skin, and subcutis, presents a quick and aggressive clinical behavior. Hemangiosarcoma (HAS) is a malignant neoplasm of endothelial vessel cells commonly reported to affect the right atrium of dogs' hearts. A male Rottweiler, five years old, presented flaccid paraplegia and progressive muscular atrophy in the temporal, masseter, and limbs muscles; Due to the clinical stage of the animal, euthanasia was conducted. During the necroscopic examination, it was noticed that several masses presented different sizes; some were whitish, and others were reddish and spread in multiple organs (lungs, heart, spleen, stomach, kidneys, brain, medulla, skeletal muscle, and pre-scapular lymph node). Microscopically, in some organs such as the stomach, right ventricle, lungs, and medulla, it was noticed a proliferation of myeloid cells, highly cellular, with poor demarcation, no encapsulation, and with the infiltrative growth pattern of cells with high pleomorphism. Numerous tumoral emboli were observed in the spleen, brain, skeletal muscle, and lymph node. These cells were submitted for immunohistochemistry and were positive for CD18 (HS antibody). In the right atrium, liver, and kidney it was observed malignant and infiltrative endothelial proliferation (HSA) and emboli in the medulla. Therefore, we conclude that both neoplasms (HS and HSA) cause the animal's paraplegia due to their embolism and metastasis to the spinal cord and skeletal muscle.

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Section: Introductionmentioning

confidence: 99%

Concomitant occurrence of multicentric hemangiosarcoma and histiocytic sarcoma in a dog

Gouveia¹,

Perossi²,

Silva³

et al. 2023

BJVP

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It's not always histiocytic sarcoma: Immunocytochemistry to identify two unusual tumors in a Bernese Mountain dog

Quinn,

Harding,

Schlein

et al. 2024

Veterinary Clinical Pathol

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A 7‐year‐old female spayed Bernese Mountain dog was presented for evaluation of hematuria. Incidentally, a right stifle sarcoma was diagnosed via cytology, which raised concern for histiocytic sarcoma (given the patient's signalment) versus another joint‐associated sarcoma. Histopathology and immunohistochemistry revealed a CD18‐negative, non‐histiocytic origin cell population. Findings were consistent with a joint‐associated grade II soft tissue sarcoma (STS). The patient's hematuria was progressive over 5 months, and urinary bladder transitional cell carcinoma (TCC) was diagnosed via cystoscopy and histopathology. An enlarged right medial iliac lymph node was identified on routine restaging via abdominal ultrasound 3 months later. Cytology of the lymph node revealed a markedly pleomorphic cell population, again raising concern for histiocytic sarcoma (HS). Other differentials included an anaplastic metastatic population from the joint‐associated STS or the TCC. Immunocytochemistry revealed a cytokeratin‐positive, CD18‐, CD204‐, and vimentin‐negative cell population, consistent with a carcinoma. DNA was extracted from cytology slides to sequence cells for BRAF mutation status. Sequencing revealed a homozygous V596E (transcript ENSCAFT00845055173.1) BRAF mutation, consistent with the known biology of TCC. In neither case was HS truly present in this patient, but immunocytochemistry provided information that helped to optimize the patient's chemotherapy recommendations.

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Disseminated histiocytic sarcoma in a Labrador retriever in Brazil

Cited by 2 publications

References 9 publications

Concomitant occurrence of multicentric hemangiosarcoma and histiocytic sarcoma in a dog

Concomitant occurrence of multicentric hemangiosarcoma and histiocytic sarcoma in a dog

It's not always histiocytic sarcoma: Immunocytochemistry to identify two unusual tumors in a Bernese Mountain dog

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