Disseminated histoplasmosis caused by Histoplasma capsulatum var. duboisii in a non-HIV patient in Burkina Faso: Case report

Zida, Adama; Niamba, P.; Barro-Traoré, F.; Korsaga-Somé, Nina; Tapsoba, P.; Briegel, Josef; Guiguemdé, Robert Tinga

doi:10.1016/j.mycmed.2015.03.002

Cited by 17 publications

(12 citation statements)

References 6 publications

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“…In addition to these invasive infections, HIV infection is well-known as a major predisposing factor for oral thrush and its extension to the oesophagus, which may occur in 24,300 and 7450 cases, respectively. While Histoplasma capsulatum seems to be endemic to the region, there are no data on disseminated histoplasmosis in AIDS from Burkina Faso [ 18 , 19 , 20 , 21 ]. Deaths from AIDS are estimated at 3600, and it is likely that the above estimates for fungal diseases are underestimated.…”

Section: Resultsmentioning

confidence: 99%

“…Some cases of Histoplasma capsulatum var. duboisii histoplasmosis have been reported over decades, but the prevalence cannot be estimated [ 18 , 19 , 20 , 21 ]. A few cases of mycetoma and rhino-facial entomophtoromycosis have also been reported from Burkina Faso [ 26 , 27 , 28 ], but to the best of our knowledge, there are no data on other subcutaneous fungal infections (i.e., chromoblastomycosis, sporotrichosis) from Burkina Faso, although they are expected.…”

Section: Resultsmentioning

confidence: 99%

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Burden of Severe Fungal Infections in Burkina Faso

Bamba¹,

Zida

Sangaré³

et al. 2018

JoF

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Because of the limited access to more powerful diagnostic tools, there is a paucity of data regarding the burden of fungal infections in Burkina Faso. The aim of this study was to estimate the incidence and prevalence of serious fungal infections in this sub-Saharan country. We primarily used the national demographic data and performed a PubMed search to retrieve all published papers on fungal infections from Burkina Faso and its surrounding West African countries. Considering the prevalence of HIV infection (0.8% of the population) and a 3.4% incidence of cryptococcosis in hospitals, it is estimated that 459 patients per year develop cryptococcosis. For pneumocystosis, it is suggested that 1013 new cases occur every year. Taking into account the local TB frequency (population prevalence at 0.052%), we estimate the prevalence of chronic pulmonary aspergillosis at 1120 cases. Severe forms of asthma with fungal sensitization and allergic bronchopulmonary aspergillosis are estimated to affect 7429 and 5628 cases, respectively. Vulvovaginal candidiasis may affect 179,000 women, and almost 1,000,000 children may suffer from tinea capitis. Globally, we estimate that roughly 1.4 million people in Burkina Faso (7.51% of the population) suffer from a serious fungal infection. These data should be used to drive future epidemiological studies, diagnostic approaches, and therapeutic strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Burden of Severe Fungal Infections in Burkina Faso

Bamba¹,

Zida

Sangaré³

et al. 2018

JoF

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“…Although adrenal function is not recoverable, there are some reports of patients who have gained adrenal functions after prolonged antifungal therapy [1]. In addition, fluconazole and ketoconazole can also be used as an alternative in moderate to severe disease [1,10].…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Possible Disseminated Histoplasmosis with Adrenal Insufficiency Leading to Adrenal Crisis in an Immunocompetent Adult: A Case Report

Jayathilake

Kumarihamy

Ralapanawa

et al. 2020

Case Reports in Medicine

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Histoplasmosis is caused by Histoplasma capsulatum, and commonly it causes an asymptomatic illness. Although Histoplasma is the commonest organism to infect adrenal glands, disseminated histoplasmosis in an immune-competent host leading to adrenal insufficiency is rare in current literature. Here, we report a case of possible disseminated histoplasmosis leading to adrenal crisis in a young Asian immunocompetent male. A 42-year-old Sri Lankan male with noninsulin-dependent diabetes mellitus presented with constitutional symptoms and feverishness for three weeks’ duration. He was found to have hepatosplenomegaly with bilateral adrenal masses and pancytopenia. One week later, he developed severe vomiting and hemodynamic collapse and was found to have suppressed adrenal functions. Ultrasound-guided biopsy of adrenals showed fungal spores morphologically similar to Histoplasma. He was started on oral itraconazole and adrenal replacement therapy. He improved symptomatically with treatment and currently is on regular clinic follow-up with a plan to continue antifungal therapy for at least one year to prevent a relapse. Fungal infections, especially histoplasmosis, need to be considered in all immunocompetent patients with compatible history and bilateral adrenal masses. Adrenal insufficiency needs to be promptly diagnosed and treated to prevent Addisonian crisis in these patients.

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“…In Africa, most of the reported cases are prior to the AIDS pandemic. These are very often clinical cases and the actual frequency of histoplasmosis is not known [ 9 , 10 ]. Recent African literature mentions very few cases of histoplasmosis associated with HIV infection [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…These examined specimens, consisting of cutaneous biopsies and lymph nodes, are related to the clinical manifestations of histoplasmosis, which are often mucocutaneous, ganglionic, and osseous [ 6 , 9 ]. Although lesions are often localized, disseminated forms have been described in children by other authors associating a generalized, multiple osteoarticular, multiganglionic, hepatic, and splenic cutaneous localization [ 6 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo

Darré

Saka

Mouhari-Touré

et al. 2017

Journal of Pathogens

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Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1.8. The annual incidence was 1.1 cases. The mean age of the patients was 27.2 ± 0.4 years. All our patients were of social categories with a low socioeconomic level. HIV infection was known in 3 patients and one patient contracted tuberculosis. The clinical manifestations were cutaneous in 7 cases, cutaneous and mucous in 3 cases, cutaneous and lymph node in 3 cases, cutaneous and bone in 2 cases, and disseminated in 2 cases. The samples examined consisted of 14 cutaneous biopsies measuring 2-3 cm and 3 ganglionic biopsies each measuring 4 cm of major axis. Histologically, all cases were of chronic form made of granulomatous reaction with ovoid yeasts measuring between 1 and 2 microns. Despite the low frequency of this disease in our country, it should be kept constantly in mind before any granulomatous lesions, especially in the context of the HIV pandemic.

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Disseminated histoplasmosis caused by Histoplasma capsulatum var. duboisii in a non-HIV patient in Burkina Faso: Case report

Cited by 17 publications

References 6 publications

Burden of Severe Fungal Infections in Burkina Faso

Burden of Severe Fungal Infections in Burkina Faso

A Rare Presentation of Possible Disseminated Histoplasmosis with Adrenal Insufficiency Leading to Adrenal Crisis in an Immunocompetent Adult: A Case Report

Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo

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