Disseminated Histoplasmosis: Cutaneous (Subcutaneous Abscess), Vesical and Prostatic Histoplasmosis

Reddy, Prathapchandra; Sutaria, Maganlal; Brasher, Charles A.; Christianson, Charles S.

doi:10.1097/00007611-197007000-00016

Cited by 5 publications

(6 citation statements)

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“…Acute histoplasmosis results from a high-inoculum, the primary focus is generally pulmonary and such individuals have diverse, nonspecific symptoms, with severity of symptoms correlating with the magnitude of exposure (85,108,126,153). The disseminated form is defined by the presence of an extrapulmonary focus and normally is a progressive illness occurring more frequently in immunocompromised individuals, such as patients who are receiving corticosteroids, cytotoxic therapy, and immunosuppressive agents or individuals with HIV infection (55,111,118,135). Commonly seen is chronic histoplasmosis, which happens in the setting of preexisting abnormal lung architecture.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of histoplasmosis

Guimarães

Nosanchuk²,

Zancopé‐Oliveira³

2006

Braz. J. Microbiol.

176

206

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Endemic mycoses can be challenging to diagnose and accurate interpretation of laboratory data is important to ensure the most appropriate treatment for the patients. Although the definitive diagnosis of histoplasmosis (HP), one of the most frequent endemic mycoses in the world, is achieved by direct diagnosis performed by micro and/or macroscopic observation of Histoplasma capsulatum (H. capsulatum), serologic evidence of this fungal infection is important since the isolation of the etiologic agents is time-consuming and insensitive. A variety of immunoassays have been used to detect specific antibodies to H. capsulatum. The most applied technique for antibody detection is immunodiffusion with sensitivity between 70 to 100 % and specificity of 100%, depending on the clinical form. The complement fixation (CF) test, a methodology extensively used on the past, is less specific (60 to 90%). Detecting fungal antigens by immunoassays is valuable in immunocompromised individuals where such assays achieve positive predictive values of 96-98%. Most current tests in diagnostic laboratories still utilize unpurified antigenic complexes from either whole fungal cells or their culture filtrates. Emphasis has shifted, however, to clinical immunoassays using highly purified and well-characterized antigens including recombinant antigens. In this paper, we review the current conventional diagnostic tools, such as complement fixation and immunodiffusion, outline the development of novel diagnostic reagents and methods, and discuss their relative merits and disadvantages to the immunodiagnostic of this mycosis.

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Section: Introductionmentioning

confidence: 99%

Diagnosis of histoplasmosis

Guimarães

Nosanchuk²,

Zancopé‐Oliveira³

2006

Braz. J. Microbiol.

176

206

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“…In the 1961 case, there was no evidence of genitourinary involvement before autopsy [7]. Hematuria was noted late in the course of the second case, and significant granulomatous bladder lesions were also found at autopsy [8].…”

Section: Discussionmentioning

confidence: 92%

“…The prostate was mentioned in a long list of organs where the organism was found at autopsy. Further cases in 1961 and 1970 reported significant caseating prostatic inat UCSF Library and Center for Knowledge Management on March 11, 2015 http://cid.oxfordjournals.org/ Downloaded from volvement in addition to disease in the lungs and adrenal glands in previously healthy individuals [7,8]. In the 1961 case, there was no evidence of genitourinary involvement before autopsy [7].…”

Section: Discussionmentioning

confidence: 99%

“…Overall, only 8 cases of histoplasma prostatitis have been previously reported (table 1) [5][6][7][8][9][10][11][12]. The first mention of prostatic involvement occurred in a 1958 case where intestinal polyposis was found during antemortem biopsy and subsequent autopsy to be due to both Peutz-Jeghers syndrome and histoplasmosis [5].…”

Section: Discussionmentioning

confidence: 99%

“…We discuss the challenging and instructive diagnostic issues that this case highlights. To provide context, our case is compared with CNS and prostatic mycoses, especially the 8 previously reported cases of histoplasmosis involving the prostate gland [5][6][7][8][9][10][11][12].…”

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confidence: 99%

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Prostatic and Central Nervous System Histoplasmosis in an Immunocompetent Host: Case Report and Review of the Prostatic Histoplasmosis Literature

Mawhorter¹,

Curley²,

Kursh³

et al. 2000

Clinical Infectious Diseases

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Histoplasmosis is a common cause of systemic mycosis in areas of the United States where it is endemic. Central nervous system and genitourinary histoplasmosis is rare, especially in immunocompetent hosts. We describe a case of disseminated histoplasmosis in a normal host that was associated with cerebral and prostatic histoplasmosis presenting as fever of undetermined origin, weight loss, and severe debilitating altered mental status. The patient subsequently developed acute renal failure that manifested as obstructive uropathy during antifungal therapy with amphotericin B. Transurethral resection of the prostate resulted in improved renal function during continuation of amphotericin B therapy. Pathological analysis of the prostate revealed necrotizing granulomas with intralesional fungal organisms. Blood and urine cultures were positive for Histoplasma capsulatum. Diagnostic issues and management are discussed. Treatment resulted in return of normal cognitive and motor function. This case is compared with the 8 previously reported cases of H. capsulatum prostatitis.

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Histoplasma capsulatum Recovery from the Urine and a Short Review of Genitourinary Histoplasmosis

2009

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Although virtually any organ can be involved in disseminated histoplasmosis, the recovery of Histoplasma capsulatum from the urine is a rare finding. Here we describe that a renal transplant recipient had H. capsulatum recovered from urinary sediment. The organism was also recovered from urine cultures. The potential implications of this finding are discussed, and the literature on genitourinary histoplasmosis is reviewed.

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Disseminated Histoplasmosis: Cutaneous (Subcutaneous Abscess), Vesical and Prostatic Histoplasmosis

Cited by 5 publications

References 0 publications

Diagnosis of histoplasmosis

Diagnosis of histoplasmosis

Prostatic and Central Nervous System Histoplasmosis in an Immunocompetent Host: Case Report and Review of the Prostatic Histoplasmosis Literature

Histoplasma capsulatum Recovery from the Urine and a Short Review of Genitourinary Histoplasmosis

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