Disseminated histoplasmosis in a patient with common variable immunodeficiency: A coincidence or the result of T cell defects?

Abstract

HighlightsT cell defects can be significant in common variable immunodeficiency.Abnormal T cell activation in common variable immunodeficiency can cause massive splenomegaly.Disseminated histoplasmosis can occur in common variable immunodeficiency as a result of such T cell defects.

Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases

“…Further reports of these associations are required to validate the consistency of the fungal susceptibility, along with mechanistic insights into the causal role of the lesioned gene in TDEF immunity. The TDEF and Cryptococcus infections have also been reported in clinical syndromes that were not genetically identified or investigated, including idiopathic CD4+ lymphocytopenia (ICL) [ 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 ] and common variable immunodeficiency (CVID) [ 181 , 182 ]. In these cases, the absence of a molecular diagnosis precludes a refined understanding of immunopathogenesis.…”

Progressive disseminated histoplasmosis in idiopathic CD4 lymphocytopenia an underdiagnosed combination - a case report

“…Progressive disseminated disease is seen in the immunocompromised individuals, most commonly with HIV/ AIDS. However, it is rarely reported with immunodeficiency diseases like idiopathic CD4 lymphocytopenia (ICL) and common variable immunodeficiency (CVID) [3]. We diagnosed an unusual case of PDH in the arid zone after ruling out the common immunodeficiency states.…”