Disseminated Histoplasmosis Masquerading as Significant Weight Loss Eight Years Post Renal Transplant

Jha, Vijoy Kumar; Mahapatra, Debasish

doi:10.4103/1319-2442.292324

Cited by 8 publications

(10 citation statements)

References 10 publications

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“…The non-specific signs and symptoms of GIH, as highlighted in this review, include but are not limited to abdominal pain [ 12 , 18 , 19 , 20 , 20 , 21 , 22 , 25 , 27 , 31 , 33 , 35 , 36 , 37 , 38 , 40 , 41 , 43 , 45 , 47 , 50 , 51 , 54 ], diarrhoea [ 12 , 17 , 19 , 21 , 22 , 36 , 37 , 38 , 39 , 40 , 43 , 53 , 68 , 74 , 75 , 103 , 104 , 105 , 106 ], fever [ 12 , 13 , 17 , 19 , 26 , 27 , 28 , 30 , 31 , 33 , 35 ], weight loss [ 13 , 31 , 77 , 79 , 84 , …”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

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Gastrointestinal histoplasmosis (GIH) is infrequently described in people without underlying HIV infection. We aimed to compare the clinical presentation of GIH in people with and without HIV infection. We conducted a literature search of published cases of GIH from 2001–2021 and found 212 cases. Of these, 142 (67.0%) were male, and 124 (58.5%) had HIV infection. Most cases were from North America (n = 88, 41.5%) and South America (n = 79, 37.3%). Of the 212 cases, 123 (58.0%) were included in both clinical and pathological analyses. The remainder were excluded as details about clinical and pathological findings were not available. Of the 123 cases, 41 had HIV infection while 82 were without HIV infection. The diagnosis was predominantly by histopathology (n = 109, 88.6%). A significant proportion of people with HIV infection had abdominal pain as the most predominant symptom of GIH compared to those without HIV infection (65.9% versus 41.9%, p < 0.05). The colon was the most affected site with a slightly higher proportion in those with HIV infection compared with cases without HIV infection (46.3% versus 42.7%). The commonest pathologic findings were caecal and ileal ulcers. Caecal ulcers were significantly more frequent in cases with HIV infection compared to those without HIV (32.1% versus 7.1%, p < 0.05). Despite being more common in people with HIV infection, GIH also affects people without HIV infection with similar clinical presentations.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

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“…1 Despite its worldwide distribution, cases of histoplasmosis reported from India are limited. 2 Here, we are reporting a rare case of disseminated histoplasmosis with refractory thrombocytopenia.…”

Section: Fungal Infection Histoplasmosis Renal Transplant Thrombocyto...mentioning

confidence: 96%

“…Histoplasmosis is an opportunistic fungal infection caused by the dimorphic fungus Histoplasma capsulatum that grows as a mold (macro‐ and microconidia) in nature and in cultures at room temperature but converts into a small (1–5 μm in diameter) yeast cell at 37°C and during invasion into the host cell 1 . Despite its worldwide distribution, cases of histoplasmosis reported from India are limited 2 . Here, we are reporting a rare case of disseminated histoplasmosis with refractory thrombocytopenia.…”

Section: Figurementioning

confidence: 99%

“…1 Despite its worldwide distribution, cases of histoplasmosis reported from India are rare. 2 In India, most cases have been reported from the eastern (West Bengal) and northeastern states (Assam), being attributed to the large rivers flowing through these states. 3 The present case and donor were not from these regions of India without any significant travel history to other endemic regions.…”

Section: Fungal Infection Histoplasmosis Renal Transplant Thrombocyto...mentioning

confidence: 99%

“…Histoplasmosis is an opportunistic fungal infection caused by Histoplasma capsulatum 1 . Despite its worldwide distribution, cases of histoplasmosis reported from India are rare 2 . In India, most cases have been reported from the eastern (West Bengal) and northeastern states (Assam), being attributed to the large rivers flowing through these states 3 .…”

Section: Figurementioning

confidence: 99%

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