Disseminated<i>Mycobacterium avium-intracellulare</i>in a kidney transplant recipient

Nagy, György; Rubin, Robert H.

doi:10.1034/j.1399-3062.2001.30406.x

Cited by 25 publications

(22 citation statements)

References 52 publications

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“…Abdominal tenderness is often mentioned in M. genavense infection. NTM infections are quite rare in solid organ recipients, with only small case series reported (4,5). None of these involved M. genavense.…”

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confidence: 99%

Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation

Nurmohamed

Weenink

Moeniralam³

et al. 2007

American Journal of Transplantation

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After solid organ transplantation, patients are susceptible to infection caused by uncommon pathogens due the immunosuppressive drug therapy. Here, we report the first case of disseminated Mycobacterium genavense infection in a HIV seronegative renal transplant patient. The most striking clinical feature was a decreased consciousness. Blood results revealed hyperammonemia with otherwise normal liver function. Occurrence of hyperammonemia and massive M. genavense infection has not been reported before.

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confidence: 99%

Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation

Nurmohamed

Weenink

Moeniralam³

et al. 2007

American Journal of Transplantation

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“…We present a case of disseminated M. gordonae infection in an otherwise healthy renal transplant recipient. Although infection with other NTM has been described in transplant recipients, we found an association of disseminated M. gordonae infection with immunosuppressive treatment (3). This finding prompted us to review the literature on the diagnosis and treatment of this rare pathogen.…”

Section: Discussionmentioning

confidence: 62%

Disseminated Mycobacterium gordonae infection in a renal transplant recipient

Broeder¹,

Vervoort²,

Assen³

et al. 2003

Transplant Infectious Dis

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The use of more intensive immunosuppressive regimens and the increasing number of patients that are exposed to immunosuppressive strategies in transplantation medicine have changed the spectrum of infections that is encountered by the clinician. We describe a 62-year-old female renal transplant recipient receiving immunosuppressive therapy who developed complaints of weight loss, diarrhoea, cough, and fever. Increased C-reactive protein and pancytopenia were found. The presence of Mycobacterium gordonae, a non-tuberculous mycobacterium, was eventually demonstrated in bronchoalveolar lavage fluid, bone marrow, spleen, and liver. Determination of the pathogen was accelerated using a Line Probe Assay, a reverse hybridisation technique using an RNA fragment specific for different mycobacterium species. Treatment was initiated using a combination of clarithromycin, ethambutol, and rifampicin. The initial response to treatment was good, but splenectomy and change of immunosuppressive and antimycobacterial therapy were necessary for long-term control of the infection. Problems in the diagnosis and treatment of this uncommon pathogen are discussed.

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“…Although the factors that influence the development of the disease are not well known, there appear to be some predisposing factors: patients with previous lung disease, lung infections by Nocardia (6), smokers, over 60 years of age, male gender, and those with a history of alcoholism. M. xenopi infection usually presents as a localized form and dissemination is rare (7).…”

Section: Discussionmentioning

confidence: 99%

Lung cavitation due to Mycobacterium xenopi in a renal transplant recipient

Martín-Penagos

Rodrigo

Ruiz

et al. 2009

Transplant Infectious Dis

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Mycobacterium xenopi is an unusual pathogen and few such cases have been reported in the literature. We report the case of a patient with a sirolimus-based immunosuppressive regimen, who developed lung cavitation. M. xenopi was isolated from the sputum. The patient was treated initially with rifampicin, isoniazid, and pyrazinamide; levofloxacin was added to the treatment regimen after M. xenopi was demonstrated. A possible relationship between sirolimus and M. xenopi infection has been postulated, probably due to the combination of pulmonary toxicity and cellular immunosuppression of rapamycin.

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DisseminatedMycobacterium avium-intracellularein a kidney transplant recipient

Cited by 25 publications

References 52 publications

Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation

Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation

Disseminated Mycobacterium gordonae infection in a renal transplant recipient

Lung cavitation due to Mycobacterium xenopi in a renal transplant recipient

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