Disseminated <i>Mycobacterium chelonae</i> Infection Presenting as Progressive Multifocal Osteomyelitis: Report of Two Cases and a Review of the Literature

Oelberg, David A.; Mendelson, Jack H.; Miller, Mark A.; Dascal, André

doi:10.1155/1994/801012

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Mortality associated with localised infection is very rare, but there have been case reports previously of mortality with disseminated infection 11. Particularly patients who are immune suppressed are prone to prolonged periods of morbidity or mortality with disseminated spread of this infection.…”

Section: Outcome and Follow-upmentioning

confidence: 99%

Case of atypical cutaneousMycobacteriumchelonaeinfection in patient of systemic lupus erythematosus after cyclophosphamide therapy

2019

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Mycobacteriumchelonae is one of the rapidly growing non-tuberculous mycobacteria that can be isolated from water, soils and aerosols. Localised infections have been reported associated with tattoo parlours, pedicures and cosmetic procedures. But disseminated infection is usually associated with individuals who are immunocompromised, predominantly affecting limbs but sparing abdomen and back. We herein present a case where patient was on immunosuppressive therapy and developed locally severe infection around right ankle. A 69-year-old woman known to rheumatology presents in outpatients with severe pain in right ankle, unable to bear weight, oedematous right foot and lower leg. There was extensive erythematous cellulitic skin rash around right ankle and lower leg. She had background history of systemic lupus erythematosus with previous history of cardiac myositis and left foot drop. She had six cycles of cyclophosphamide for flare of lupus and after last cycle developed this presentation. Skin biopsy was arranged with dermatologist, cultures from which grew M.chelonae. She was admitted and started on triple regimen for M.chelonae as per Microbiology guidelines with intention to complete 6–12 months treatment. Patient responded very well to treatment but unfortunately, she died after 5 months on treatment due to other comorbidities and likely cause of death was cardiac arrhythmia.

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Section: Outcome and Follow-upmentioning

confidence: 99%

Case of atypical cutaneousMycobacteriumchelonaeinfection in patient of systemic lupus erythematosus after cyclophosphamide therapy

2019

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Section: Introductionmentioning

confidence: 99%

“…The most common clinical manifestation encountered with Mycobacterium chelonae is localized soft tissue infections in immunocompetent hosts [ 1 ]. These infections typically are sporadic and tend to occur at sites of trauma such as penetrating injury or surgical incision [ 1 ]. Less commonly, disseminated infections may occur on a background of immunosuppression caused by medications (anti-tumor necrosis factor therapy, corticosteroids, and methotrexate) or diseases (AIDS, malignancy) [ [2] , [3] , [4] ].…”

Section: Introductionmentioning

confidence: 99%

Necrotizing osteomyelitis in a man with disseminated Mycobacterium chelonae infection

Harp

Achcar

Drummond

2018

IDCases

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Cases of disseminated nontuberculous mycobacterial (NTM) infection are difficult to treat. We encountered an elderly man with disseminated Mycobacterium chelonae infection. The clinical evaluation and treatment of patients with this type of systemic infection pose unique challenges. Disseminated NTM infection with bone involvement often requires surgical intervention in addition to antimicrobial therapy.

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Histopathological Features of Mycobacterium chelonae Infection in Two Farmed Japanese Pufferfish (Takifugu rubripes)

Ishii¹,

Kawakami²,

Mekata

et al. 2019

Journal of Comparative Pathology

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Disseminated Mycobacterium chelonae Infection Presenting as Progressive Multifocal Osteomyelitis: Report of Two Cases and a Review of the Literature

Cited by 5 publications

References 21 publications

Case of atypical cutaneousMycobacteriumchelonaeinfection in patient of systemic lupus erythematosus after cyclophosphamide therapy

Case of atypical cutaneousMycobacteriumchelonaeinfection in patient of systemic lupus erythematosus after cyclophosphamide therapy

Necrotizing osteomyelitis in a man with disseminated Mycobacterium chelonae infection

Histopathological Features of Mycobacterium chelonae Infection in Two Farmed Japanese Pufferfish (Takifugu rubripes)

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