Disseminated Infection due to Cylindrocarpon (Fusarium) lichenicola in a Neutropenic Patient with Acute Leukaemia: Report of a Case and Review of the Literature

Rodriguez-Villalobos, Hector; Georgala, Aspasia; Beguin, Hugues; Heymans, C; Pye, G.; Crokaert, Françoise; Aoun, Mickaël

doi:10.1007/s10096-002-0851-9

Cited by 21 publications

(6 citation statements)

References 12 publications

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“…We identified 97 cases of invasive fusariosis from the literature published since 2000. 1 – 4 , 6 – 13 , 16 , 18 , 20 – 27 , 31 – 33 , 37 – 39 , 42 – 44 , 46 , 48 , 50 – 57 , 59 , 61 , 62 , 65 – 67 , 69 – 71 , 74 – 81 , 83 – 85 , 87 , 89 , 91 , 97 , 99 , 100 – 103 , 105 – 108 , 111 – 113 , 115 – 121 , 124 – 126 , 128 – 135 , 139 , 140 The patients’ mean age was 45 years (range, 3 mo to 85 yr). Fifty-four patients were male and 41 female (sex was not reported in 2 cases).…”

Section: Resultsmentioning

confidence: 99%

Fusarium Infection

Muhammed¹,

Anagnostou²,

Desalermos³

et al. 2013

Medicine

138

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Fusarium species is a ubiquitous fungus that causes opportunistic infections. We present 26 cases of invasive fusariosis categorized according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria of fungal infections. All cases (20 proven and 6 probable) were treated from January 2000 until January 2010. We also review 97 cases reported since 2000. The most important risk factors for invasive fusariosis in our patients were compromised immune system, specifically lung transplantation (n = 6) and hematologic malignancies (n = 5), and burns (n = 7 patients with skin fusariosis), while the most commonly infected site was the skin in 11 of 26 patients. The mortality rates among our patients with disseminated, skin, and pulmonary fusariosis were 50%, 40%, and 37.5%, respectively. Fusarium solani was the most frequent species, isolated from 49% of literature cases. Blood cultures were positive in 82% of both current study and literature patients with disseminated fusariosis, while the remaining 16% had 2 noncontiguous sites of infection but negative blood cultures. Surgical removal of focal lesions was effective in both current study and literature cases.Skin lesions in immunocompromised patients should raise the suspicion for skin or disseminated fusariosis. The combination of medical monotherapy with voriconazole or amphotericin B and surgery in such cases is highly suggested.

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Section: Resultsmentioning

confidence: 99%

Fusarium Infection

Muhammed¹,

Anagnostou²,

Desalermos³

et al. 2013

Medicine

138

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“…The outgroup was Sclerotinia sclerotiorum. keratitis, cutaneous lesions, disseminated infections in immune-compromised patients, and peritonitis in patients on peritoneal dialysis (James et al 1997;Sharma et al 1998;Summerbell and Schroers 2002;Villalobas et al 2003;Chazan et al 2004).…”

Section: Discussionmentioning

confidence: 99%

The Fusarium solani species complex infecting cannabis (Cannabis sativa L., marijuana) plants and a first report of Fusarium (Cylindrocarpon) lichenicola causing root and crown rot

Punja

Roberts

2021

Canadian Journal of Plant Pathology

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Greenhouse-grown cannabis (Cannabis sativa L., marijuana) plants with yellowing, crown rot and root-browning symptoms were sampled from six production facilities during 2019-2020. Among 34 fungal isolates recovered, 28 were identified as Fusarium solani and six isolates were provisionally identified as Cylindrocarpon sp. based on morphology. These latter isolates produced slowgrowing colonies with grey-white aerial mycelium and a chestnut-brown colour below. Cylindrical 1-3 septate conidia without a distinctive foot cell were produced. Microconidia were absent and chlamydospores were produced in culture. Phylogenetic analysis of three isolates based on the elongation factor (TEF-1 α) and ITS1-5.8S-ITS2 regions identified them as Fusarium lichenicola (formerly Cylindrocarpon lichenicola), a member of F. solani species complex (FSSC) subclade 16. Pathogenicity tests using a mycelial and spore suspension were performed on cannabis cuttings and rooted plants. Isolates of F. solani originating from diseased crowns caused symptoms in 10-14 days, while those of F. lichenicola caused yellowing and wilting after 3 weeks, suggesting that F. lichenicola is less virulent. Inoculum of F. lichenicola was detected in coco coir samples used for plant propagation. Previous reports of F. lichenicola are from tropical climates, where the fungus has been associated with dermal and ocular infections of human tissues, with a few reports of it causing diseases on pomelo fruits, taro corms and tea plants. This study demonstrates the first occurrence worldwide of F. lichenicola on cannabis plants, on which it is considered a weak introduced tropical pathogen, likely to have originated from coco coir imported into Canada.

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“…More recently, case reports have documented success with dual antifungal therapy (L‐AMB and voriconazole) . However, the evidence is mixed with one case series showing no benefit, while another single‐centre series found a higher mortality (level IV evidence) .…”

Section: Fusariosismentioning

confidence: 99%

Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014

Blyth

Gilroy

Guy

et al. 2014

Internal Medicine Journal

122

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Mould species represent the pathogens most commonly associated with invasive fungal disease in patients with haematological malignancies and patients of haemopoietic stem cell transplants. Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While Aspergillus species remain the most prevalent cause of invasive mould infections, Scedosporium and Fusarium species and the Mucormycetes continue to place a significant burden on the immunocompromised host. Evidence also suggests that infections caused by rare and emerging pathogens are increasing within the setting of broad-spectrum antifungal prophylaxis and improved survival times placing immunosuppressed patients at risk for longer. These guidelines present evidence-based recommendations for the antifungal management of common, rare and emerging mould infections in both adult and paediatric populations. Where relevant, the role of surgery, adjunctive therapy and immunotherapy is also discussed.

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Disseminated Infection due to Cylindrocarpon (Fusarium) lichenicola in a Neutropenic Patient with Acute Leukaemia: Report of a Case and Review of the Literature

Cited by 21 publications

References 12 publications

Fusarium Infection

Fusarium Infection

The Fusarium solani species complex infecting cannabis (Cannabis sativa L., marijuana) plants and a first report of Fusarium (Cylindrocarpon) lichenicola causing root and crown rot

Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014

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