Disseminated intravascular coagulation associated with hepatitis in late pregnancy

Jones, C. T.; Birch, Carsten; Poller, L.; Dymock, I. W.

doi:10.1136/gut.14.11.891

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…492,494,495 DIC has also been reported in association with fulminant hepa titis of late pregnancy. 496 In cirrhosis, the severity of DIC may be directly related to the time course of development and severity of portal hypertension. 492 Despite the attendant risks of hemorrhage, heparin therapy has been utilized in fulminant hepatic failure.…”

Section: Liver Diseasementioning

confidence: 99%

Clinical Aspects of Disseminated Intravascular Coagulation: A Clinician's Point of View

Baker¹

1989

Semin Thromb Hemost

151

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DIC is a disorder of coagulation that is demonstrated to occur in many settings. In view of the fulminant nature of the disorder once it is fully activated, the potential for considerable morbidity and mortality, and the difficulty in treating this syndrome, the necessity for a thorough understanding of the disorder is clear. A high index of suspicion is absolutely essential; however, this requires a thorough knowledge of the medical and surgical disorders in which DIC is likely to occur. The presenting manifestations of DIC, the time course of development of the fulminant syndrome, and the specific complications of the disorder may be intrinsically related to the specific clinical characteristics of the underlying disease. Clinical evaluation of the patient must be comprehensive and consider not only the laboratory and clinical manifestations of DIC but the triggering illness. Without the ability to treat the underlying primary illness, controlling or abating the DIC may be difficult or impossible. This comprehensive review of the disease entities in which DIC is likely to occur and the associated clinical manifestations will, it is hoped, guide a more precise definition of the overall clinical picture that confronts the clinician when evaluating a patient with possible DIC.

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Section: Liver Diseasementioning

confidence: 99%

Clinical Aspects of Disseminated Intravascular Coagulation: A Clinician's Point of View

Baker¹

1989

Semin Thromb Hemost

151

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“…This case is very valuable because it is the only case of liver hemangiosarcoma in the literature [15] on DIC as related to a malignant liver tumor, whereas there are many reports on DIC and hepatitis or liver cirrhosis [16][17][18][19],…”

Section: Sephadex G-200 Column Chromatography Of Plasma Of the Patienmentioning

confidence: 99%

A Case of Ruptured Hepatoma Followed by Elastase-Induced Disseminated Intravascular Coagulation

Sumiyoshi¹,

Nishiki²,

Kanao³

et al. 1985

Enzyme

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In the present study, the first case of ruptured hepatoma followed by disseminated intravascular coagulation is reported. An elastase-like enzyme which possessed elastolytic and caseinolytic activities was confirmed from patient plasma. On the other hand, no elastase activity was detected in the plasma of patients with hepatitis, liver cirrhosis or hepatoma without disseminated intravascular coagulation. The patient plasma did not possess H-D-Val-Leu-Lys-p-nitroanilide hydrochloride, succinyl-L-alanyl-L-alanyl-p-nitroanilide, and pyro-Glu-Pro-Val-p-nitroanilide amidolytic activities. However, when chromatographed on Sephadex G-200, the presence of low-molecular weight plasminogen was confirmed. Its molecular weight was approximately 52,000. A slight decrease of α2-plasmin inhibitor was noted, but no decrease of α2-macroglobulin was detected.

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Coagulation Studies as a Prognostic Index in Acute Liver Failure

et al. 1975

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A coagulation screen has been performed on 12 patients with acute liver failure. Six died and six recovered. All six fatal cases developed a haemorrhagic state with haemostatic failure. An attempt has been made to delineate the various mechanisms for the production of the coagulation defect. The significance of the different haematological parameters in assessing prognosis has been assessed. The study emphasizes the importance of the synthetic ability of the liver in determining survival prospects. A good correlation between the factor-VII level, which is a guide to liver synthesis, and recovery has been shown. The value of a specific factor-VII assay in acute liver failure appears considerable. Where this assay cannot be performed the clot opacity fibrinogen technique provides a reasonable guide to the prognosis. The presence or absence of DIC was not a determinant factor in survival in this series.

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Disseminated intravascular coagulation associated with hepatitis in late pregnancy

Cited by 5 publications

References 8 publications

Clinical Aspects of Disseminated Intravascular Coagulation: A Clinician's Point of View

Clinical Aspects of Disseminated Intravascular Coagulation: A Clinician's Point of View

A Case of Ruptured Hepatoma Followed by Elastase-Induced Disseminated Intravascular Coagulation

Coagulation Studies as a Prognostic Index in Acute Liver Failure

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