Disseminated intravascular coagulation in a dog naturally infected by Leishmania (Leishmania) chagasi from Rio de Janeiro – Brazil

Honse, C. O.; Figueiredo, Fabiano Borges; Alencar, Nayro Xavier de; Madeira, Maria de Fátima; Gremião, Isabella Dib Ferreira; Schubach, Tânia Maria Pacheco

doi:10.1186/1746-6148-9-43

Cited by 16 publications

(17 citation statements)

References 32 publications

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“…In addition, platelet loss may be associated with hypercoagulability caused by a decreased concentration of antithrombin III due to protein‐losing nephropathy (see below). Disseminated intravascular coagulation (DIC) has been occasionally reported in leishmaniotic dogs . However, thrombocytopenia in leishmaniotic dogs can also be due to suppressed platelet production in the bone marrow.…”

Section: Laboratory Abnormalities That May Support or Confirm Leishmamentioning

confidence: 99%

“…Activated partial thromboplastin time and prothrombin time may be prolonged; however in most cases, this is likely due to preanalytic factors such as an increased concentration of total globulins, which is frequent in dogs with leishmaniasis. Alternatively, prolonged coagulation times may result from DIC, although this complication is uncommon in leishmaniotic dogs …”

Section: Laboratory Abnormalities That May Support or Confirm Leishmamentioning

confidence: 99%

“…Disseminated intravascular coagulation (DIC) has been occasionally reported in leishmaniotic dogs. 40 However, thrombocytopenia in leishmaniotic dogs can also be due to suppressed platelet production in the bone marrow. Finally, reduced platelet function has been described in dogs with normal platelet concentrations in canine leishmaniasis 41 , although this reduced function is rarely responsible for hemostatic abnormalities.…”

Section: Hematologic Abnormalitiesmentioning

confidence: 99%

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Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

149

232

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Although several reviews on canine leishmaniasis have been published, none thoroughly described clinicopathologic abnormalities and their clinical usefulness. The aim of this review was to provide information concerning current diagnostic tests relevant for clinical pathologists and from a practical perspective. Specifically, in canine leishmaniasis, nonregenerative normocytic normochromic anemia, thrombocytopenia, or leukogram changes may be present. Clinical chemistry and urinalysis may indicate renal dysfunction (azotemia, decreased urine specific gravity, proteinuria) and an inflammatory/immune response (increased acute phase proteins [APP] or α - and/or γ-globulins). Although a potential gammopathy is usually polyclonal, it may also appear oligo- or monoclonal, especially in dogs coinfected by other vector-borne pathogens. When lesions are accessible to fine-needle aspiration (lymphoadenomegaly, nodular lesions, joint swelling), cytology is strongly advised, as the presence of Leishmania amastigotes in a pattern of pyogranulomatous inflammation or lymphoplasmacytic hyperplasia is diagnostic. If the cytologic pattern is inconclusive, the parasite should be identified by histology/immunohistochemistry or PCR on surgical biopsies. Alternatively, cytology and PCR may be performed on bone marrow samples where amastigotes, along with erythroid hypoplasia, myeloid hyperplasia, plasmacytosis, or secondary dysmyelopoiesis can be observed. Dogs with overt leishmaniasis generally have high antibody titers, while low titers predominate in immunologically resistant infected dogs or in exposed dogs with no parasite confirmation. Quantitative serology is recommended in clinically suspect dogs as high-titer antibodies titers may confirm the clinical diagnosis. In confirmed and treated dogs, renal function and inflammatory/immune response variables should be periodically monitored.

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Section: Laboratory Abnormalities That May Support or Confirm Leishmamentioning

confidence: 99%

Section: Laboratory Abnormalities That May Support or Confirm Leishmamentioning

confidence: 99%

Section: Hematologic Abnormalitiesmentioning

confidence: 99%

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Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

149

232

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“…Es posible que algunos pacientes desarrollen otras complicaciones tales como la coagulación intravascular diseminada, asociado probablemente a las hemorragias, al consumo de plaquetas y factores de coagulación. Esta complicación no ocurre de manera primaria, suele venir precedida de otros trastornos o condiciones clínicas como sepsis y hemólisis, las cuales coinciden con pacientes infectados por el parásito (15).…”

Section: Presentación Clínica De La Leishmaniosis Caninaunclassified

“…This complication is not primary. The complication is usually preceded by other disorders or clinical conditions such as sepsis and hemolysis, which coincides in patients infected by the parasite (15).…”

Section: Presentación Clínica De La Leishmaniosis Caninamentioning

confidence: 99%

Canine Leishmaniosis: tools for diagnosis in veterinary practice in Colombia

B²,

B³

et al. 2015

Rev MVZ Córdoba

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The objective of this article is to perform a critical analysis and guide veterinarians in the management of canine Leishmaniosis. A systematic literature review was performed between 2005 and 2014 including scientific papers which take into account experiences and reports of: pathogenesis, diagnosis, clinical presentation, treatment, vaccination, prevention and control strategies. We discuss the different aspects of VL management and aspects that should be taken into account depending on the country, after a patient is suspected or confirmed as positive, including the possibility of euthanasia. We describe the different clinical manifestations of the disease, diagnosis, signs and treatment of canine leishmaniosis. Canine leishmaniosis is present in different parts of the country, therefore it must be considered as a possible differential diagnosis in the veterinary clinic, in patients with dermatological and systemic signs that are compatible with various diseases. In Colombia, the patients diagnosed with cutaneous leishmaniasis could be treated and have a favorable prognosis, whereas in canines with diagnosis of visceral leishmaniasis euthanasia should be considered because of the public health implications.Key words: Diagnosis differential, leishmania, reservoirs, zoonoses (Source: DeSC). RESUMENSe realiza un análisis crítico con el fin de orientar a los médicos veterinarios en el tema de Leishmaniosis canina. Se realizó una revisión de literatura a partir del año 2005 de manera sistemática considerando artículos científicos donde se tuvieran en cuenta experiencias y reportes de la patogenia, diagnóstico, presentación clínica de la enfermedad, tratamiento, la vacunación, el abordaje de los casos, estrategias de prevención y control y las consideraciones que se deben tener, según el país, ante la sospecha o confirmación de un paciente positivo, entre estos aspectos, la eutanasia. Se presentan las diferentes manifestaciones clínicas de la enfermedad, el diagnóstico, los signos y tratamiento de un paciente sospechoso para leishmaniosis canina, a manera de orientación para el profesional de la clínica veterinaria. La leishmaniosis canina se encuentra presente en diferentes partes del país, por lo que debe considerarse como posible diagnóstico diferencial en la clínica veterinaria, en pacientes con signos dermatológicos y sistémicos que son compatibles con diversas enfermedades. En Colombia, los pacientes diagnosticados con leishmaniosis cutánea podrían ser tratados y tener un pronóstico favorable, mientras que en los caninos con diagnóstico de leishmaniosis visceral debe considerarse la eutanasia por las implicaciones en salud pública.Palabras clave: Diagnóstico diferencial, leishmania, reservorios, zoonosis (Fuentes: DeSc). REVISIÓN DE LITERATURARev.MVZ Córdoba 20(3):4822-4842, 2015. ISSN: 0122-0268 4823 INTRODUCCIÓNLa Leishmaniosis es una enfermedad transmitida por vectores a los seres humanos y animales. Es causada por parásitos protozoarios del género Leishmania. Los caninos son susceptibles de adquir...

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Hypertrophic osteopathy and suspected subsequent disseminated intravascular coagulation in a dog with an abdominal gossypiboma

Doyle

Hall

Hughes

et al. 2022

Vet Record Case Reports

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An 8-year-old, female, neutered cocker spaniel presented with progressive lethargy, inappetence and right pelvic limb lameness. Regional mastectomy and ovariohysterectomy had been performed 11 months prior. Mild neutrophilia and increased C-reactive protein were present. Radiographs revealed mild periosteal reaction of distal long bone diaphyses of all limbs, consistent with hypertrophic osteopathy. Abdominal imaging revealed a mesenteric mass with a central woven radiopaque foreign body diagnosed as a gossypiboma following surgical excision and histopathology. Postoperatively the patient developed acute decompensation of suspected chronic subclinical disseminated intravascular coagulation and suffered cardiac arrest. Hypertrophic osteopathy was confirmed with multifocal periosteal hyperostosis and concurrent myelofibrosis within the medulla of the long bones. Hypertrophic osteopathy occurs secondary to chronic inflammatory or neoplastic intrathoracic lesions and rarely due to abdominal pathology. To the authors' knowledge, this is the first description of hypertrophic osteopathy associated with an abdominal gossypiboma with sequential disseminated intravascular coagulation.

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Disseminated intravascular coagulation in a dog naturally infected by Leishmania (Leishmania) chagasi from Rio de Janeiro – Brazil

Cited by 16 publications

References 32 publications

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Canine Leishmaniosis: tools for diagnosis in veterinary practice in Colombia

Hypertrophic osteopathy and suspected subsequent disseminated intravascular coagulation in a dog with an abdominal gossypiboma

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