Disseminated intravascular coagulation in malaria: A case report

Sailo, Laltanpuii; Pradhan, Debasis; Nongthombam, Rakesh; Bhattacharyya, Prithwis

doi:10.4103/0300-1652.129665

Cited by 8 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several pathogenesis processes proposed may contribute to bleeding episodes in severe malaria, such as thrombocytopenia, impaired synthesis of blood clotting factors, and consumptive coagulopathy [8]. The classical disseminated intravascular coagulation (DIC) is encountered as a remarkable situation that appears in severe malaria [12]. Activation of the coagulation framework during malarial infection was stimulated by various procoagulants.…”

Section: Introductionmentioning

confidence: 99%

Laboratory Blood Coagulation in Sudanese with Falciparum Malaria: A Glance of Change Outcomes

Abdrhman¹,

Seed²

2020

Int J Blood Res Disord

View full text Add to dashboard Cite

Background: Malaria is a potentially life-threatening disease caused by infection of erythrocytes with one of five different types of protozoan parasites of genus plasmodia. Falciparum species is an aggressive type associated with multiple alterations in hemostasis. Patients and Methods: A cross-sectional descriptive study was undertaken to screen the effect of malaria infection on coagulation test results in adults with the falciparum malaria parasite. Forty-eight consecutive adults with falciparum malaria were studied along with controls. All were subjected for the screening of prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), and D-Dimer. Results: Changes in the coagulation parameters in the form of augmented PT, PTT and/or TT were seen in 22.9%, 4.2% and 14.6% of patients, respectively, without bleeding manifestation. D-Dimer was high in 37.5% cases. Receiver operation curve and area under the curve (AUC) analyses revealed a reasonable consistency with the density of falciparum malaria using PT (AUC = 0.69, sensitivity = 78.0% and specificity = 69.0%, cutoff = 14.3 seconds), PTT (AUC = 0.50, sensitivity = 58.3% and specificity = 62.0%, cutoff = 28.5 seconds), TT (AUC = 0.29, sensitivity = 36.1% and specificity = 55.0%, cutoff = 15.7 seconds), and D-Dimer (AUC = 0.70, sensitivity = 80.0% and specificity = 66.0%, cutoff = 0.105 mg/l). Conclusion: Falciparum malaria has a profound hemostatic impact among malaria patients. PT and D-Dimer could be applied to predict the falciparum malaria in clinical course.

show abstract

Section: Introductionmentioning

confidence: 99%

Laboratory Blood Coagulation in Sudanese with Falciparum Malaria: A Glance of Change Outcomes

Abdrhman¹,

Seed²

2020

Int J Blood Res Disord

View full text Add to dashboard Cite

show abstract

“…Spośród powikłań, które wystąpiły u pacjenta, najpoważniejszym był zespół rozsianego wykrzepiania wewnątrznaczyniowego (DIC) z nasiloną małopłytkowością. Występuje on rzadziej niż malaria mózgowa (21), niemniej nieleczony w konsekwencji może szybko doprowadzić do śmierci pacjenta. Małopłytkowość jest bardzo częstym objawem malarii (22,23), a także jest uznawana za jeden z czynników pozwalających odróżnienie malarii od innych infekcji (24,25).…”

Section: Discussionunclassified

“…Among the patient's complication, the most severe was the disseminated intravascular coagulation syndrome (DIC) with severe thrombocytopaenia. It occurs less frequently than the cerebral malaria (21), but if left untreated, it can quickly lead to death. Thrombocytopaenia is a very common sign of malaria (22,23), it is also considered as a factor which differentiates malaria from other infections (24,25).…”

Section: Case Reportmentioning

confidence: 99%

Imported malaria caused by Plasmodium falciparum – case report

2018

View full text Add to dashboard Cite

INTRODUCTION.Malaria is caused by the Plasmodium spp. which are spread through Anopheles mosquitoes. Disease is not endemic in Poland currently but can be brought from other countries, mostly from Africa and Asia. The main sign of the disease is fever with shivers repeated periodically. There is highly effective chemoprophylaxis available and treatment, which should be given quickly. CASE REPORT. A 35-year-old man have worked monthly in Nigeria since two years. He was using Malarone chemoprophylaxis, but contrary to recommendations. Patient presented to a hospital after four days of having fever in a medium-serious state. He reported three similar incidents in the past. Physical examination revealed hepatomegaly, depressive state, oliguria and diarrhoea. Lab tests showed DIC with thrombocytopenia, renal injury, liver injury, hypoalbuminemia. ECG indicated myocardial ischemia. Malaria Rapid Test and blood smear confirmed Plasmodium falciparum infection with 9,9% parasitemia. When antimalarial treatment was given, patient condition improved, but after three days in hospital he got pneumonia as a complication of malariaantibiotic admission was committed. Moreover, quinine caused temporary deafness and serological tests revealed chronic HBV infection. After 23-days of hospitalisation the patient was discharged in a good condition. A month later patient went to follow-up and only mild anaemia was shown. CONCLUSIONS. This case shown that even such severe disease like malaria can be cured well without serious complications if patient will be diagnosed quickly. Moreover patient's experience and respecting symptoms improve prognosis. There also should be stronger emphasis on the role of chemoprophylaxis -patient did not use it properly, so it did not have to prevent development of malaria.

show abstract

“…Proinflammatory cytokines interleukin (IL)-1b and tumor necrosis factor (TNF) and thrombin enhance EPCR shedding from endothelial cell surfaces via activation of mitogen-activated protein (MAP) kinase signaling pathways [32]. Collectively this leads to coagulopathy [36][37][38], complement activation (previously associated with SM and placental malaria) [39][40][41], endothelial dysfunction as reflected by increased levels of angiopoietin (Ang)-2 Box 3. EPCR and severe malaria EPCR enhances the anticoagulant and endothelial stabilizing properties of activated protein C (APC) by accelerating the thrombin-mediated activation of protein C (PC).…”

Section: Reviewmentioning

confidence: 97%

“…In these studies host endothelium-based biomarkers (e.g., Ang-2) correlate with endothelial activation, pro-coagulant responses, disease severity, and fatal outcome [31,33,[36][37][38][42][43][44][45]69]. Interestingly, interventions to modulate the Ang-Tie2 axis, such as increasing bioavailable nitric oxide and pro-Ang-1 or anti-Ang-2 strategies, may represent novel interventions to stabilize endothelium and improve disease outcome in the face of life-threatening infections such as SM [70][71][72] (Box 4).…”

Section: Cd36 Polymorphisms and Malariamentioning

confidence: 99%