Disseminated lntravascular Coagulation during a Fatal &lt;i&gt;Mycoplasma pneumoniae&lt;/i&gt; Infection

Vos, Michel De; Nimmen, L. Van; Baele, G

doi:10.1159/000208229

Cited by 25 publications

(6 citation statements)

References 10 publications

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“…There are a few case reports of M. pneumoniae infections in pediatric AIDS patients (49,210), but is not known whether the incidence or severity of pulmonary or extrapulmonary M. pneumoniae infections in AIDS patients is increased significantly or how any immunosuppressed state specifically affects host resistance to M. pneumoniae infection. Fulminant infections with multiple organ involvement and deaths due to M. pneumoniae, usually in otherwise healthy adults and children, have been reported but are uncommon (73,93,103,149,198,364,372,402,403,416,442).…”

Section: Vol 17 2004 M Pneumoniae As a Human Pathogen 707mentioning

confidence: 99%

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2004

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Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. Serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. The severity of disease appears to be related to the degree to which the host immune response reacts to the infection. Extrapulmonary complications involving all of the major organ systems can occur in association with M. pneumoniae infection as a result of direct invasion and/or autoimmune response. The extrapulmonary manifestations are sometimes of greater severity and clinical importance than the primary respiratory infection. Evidence for this organism's contributory role in chronic lung conditions such as asthma is accumulating. Effective management of M. pneumoniae infections can usually be achieved with macrolides, tetracyclines, or fluoroquinolones. As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur

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Section: Vol 17 2004 M Pneumoniae As a Human Pathogen 707mentioning

confidence: 99%

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2004

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“…It is clear that this condition should be an indirect-type extrapulmonary manifestation through immune dysregulation [46]. Disseminated intravascular coagulation is a classical, sporadic, and often fatal extrapulmonary manifestation [48][49][50][51][52], and a representative of the vascular occlusiontype extrapulmonary manifestations with systemic hypercoagulable state. This must be a consequence of immune dysregulation leading to activation of chemical mediators such as complements [48,51] or induction of procoagulant activity [50].…”

Section: Hematological (Hematopoietic System) Manifestationsmentioning

confidence: 99%

Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia

Narita

2010

Journal of Infection and Chemotherapy

221

207

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“…pneumoniae infection is rarely complicated by disseminated intravascular coagulation and multiple organ failure (3,4,8,9). In this case, it may be possible that hepato-renal dysfunction was drug-induced, however, the lactate dehydrogenase and the fibrin/fibrinogen degradation product were already elevated on admission.…”

Section: Discussionmentioning

confidence: 94%

Fulminant Mycoplasma pneumoniae Pneumonia.

Takiguchi¹,

Shikama²,

Aotsuka³

et al. 2001

Intern. Med.

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A 64-year-old womanwho was previously in good health was admitted because of progressive respiratory distress. Her chest radiograph revealed bilateral widespread alveolar infiltrates. She was given a diagnosis of pneumonia caused by Mycoplasmapneumoniaeserologically, acute respiratory distress syndrome, and disseminated intravascular coagulation. She died of multiple organ failure despite intensive therapy with mechanical ventilation, intravenous erythromycin and corticosteroids, continuous hemodiafiltration, and plasma exchange. Although Mycoplasma pneumoniae infection is usually a benign self-limited disease, this case emphasizes its potentially serious nature even in normal healthy individuals. (Internal Medicine 40: 345-348, 2001)

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Disseminated lntravascular Coagulation during a Fatal <i>Mycoplasma pneumoniae</i> Infection

Cited by 25 publications

References 10 publications

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia

Fulminant Mycoplasma pneumoniae Pneumonia.

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