1948
DOI: 10.1056/nejm194810142391601
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Disseminated Lupus Erythematosus Occurring among Student Nurses*

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Cited by 54 publications
(18 citation statements)
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“…However, the major concern regarding the use of vaccines in patients with systemic lupus has been that repeated immunizations may result in an exacerbation of the underlying disease (22). Serologically lupus is characterized by increased levels of antibodies to both endogenous and exogenous antigens, perhaps occurring as a result of defective immune control mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…However, the major concern regarding the use of vaccines in patients with systemic lupus has been that repeated immunizations may result in an exacerbation of the underlying disease (22). Serologically lupus is characterized by increased levels of antibodies to both endogenous and exogenous antigens, perhaps occurring as a result of defective immune control mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…Thus immunisation in patients with SLE is a pertinent issue and concerns regarding the safety and ef®cacy of immunising individuals with SLE have persisted for over 50 y. 3 Moreover immunisation as a potential trigger of disease retains an intuitive concern. There have been many anecdotal case reports of SLE triggered in recently immunised patients; however, few prospective studies have been undertaken.…”
Section: Introductionmentioning
confidence: 99%
“…Several factors may act as the instigators of the onset or reactivation of such disease, namely ultraviolet rays, certain drugs, preg nancy, and viral infections [1], The adminis tration of vaccines has also been associated with outbreaks of the disease [2], We present a case of SLE which had its onset after vaccina tion against hepatitis B, a fact which we have not found described in any of the literature on the subject.…”
mentioning
confidence: 99%