Disseminated "Mycobacterium genavense" infection in patients with AIDS

Böttger, Erik C.; Teske, Andreas; Kirschner, Philip; Bost, Sigrid Van; Hirschel, Bernard; Chang, Huilan; Beer, V.

doi:10.1016/0140-6736(92)90397-l

Cited by 237 publications

(180 citation statements)

References 13 publications

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“…For identification of the mycobacterial species, a hypervariable region of the 16S RNA gene was amplified and sequenced (Bottger et al, 1992;Hoop et al, 1993;Clarridge, 2004). A semi-nested polymerase chain reaction (PCR) method was used.…”

Section: Methodsmentioning

confidence: 99%

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

et al. 2007

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Section: Methodsmentioning

confidence: 99%

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

et al. 2007

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“…Disseminated infection with Mycobacterium genavense has been described mostly in patients with advanced human immunodeficiency virus (HIV) infection. 1 In HIV-negative patients, about 10 reports of disseminated M. genavense infection have been published in immunocompromised hosts, [2][3][4][5][6][7][8][9][10] including only 4 cases have occurred in transplant recipients in the last 5 years. 2,[6][7][8] We report a case in a lung transplant recipient, with a fatal outcome more than 3 years after a diagnosis owing to late-onset recurrence of the infection.…”

Section: Introductionmentioning

confidence: 99%

Relapsing Mycobacterium Genavense Infection as a Cause of Late Death in a Lung Transplant Recipient: Case Report and Review of the Literature

Lhuillier¹,

Brugière²,

Véziris³

et al. 2012

Exp Clin Transplant

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Mycobacterium genavense is recognized as a lifethreatening pathogen in severely immunocompromised patients, mostly in those with advanced human immunodeficiency virus infection. We report a case of M. genavense infection in a lung-transplant recipient with late-onset death occurring from disseminated infection. In human immunodeficiency virus-negative patients, there exist only about 10 reports of disseminated M. genavense infection in immunocompromised hosts; and to our knowledge, this is a first reported case of M. genavense infection after a lung transplant. Diagnosis of M. genavense was obtained only with nucleic acid-based identification technique, as frequently observed in a few cases of human immunodeficiency virus-negative patients. A striking feature was the recurrence of this infection in our patient after a seemingly infection-free period of 3 years. Because M. genavense infection can be life-threatening, clinicians must be aware of the frequent requirement for nucleic-acid-based identification for its diagnosis.

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“…Acute respiratory distress syndrome, diffuse intravascular coagulation, hepatic and renal failure and ultimately death rapidly followed. (2). It causes disseminated disease in severely immunocompromised individuals.…”

mentioning

confidence: 99%

Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation

Nurmohamed

Weenink

Moeniralam³

et al. 2007

American Journal of Transplantation

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After solid organ transplantation, patients are susceptible to infection caused by uncommon pathogens due the immunosuppressive drug therapy. Here, we report the first case of disseminated Mycobacterium genavense infection in a HIV seronegative renal transplant patient. The most striking clinical feature was a decreased consciousness. Blood results revealed hyperammonemia with otherwise normal liver function. Occurrence of hyperammonemia and massive M. genavense infection has not been reported before.

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Disseminated "Mycobacterium genavense" infection in patients with AIDS

Cited by 237 publications

References 13 publications

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

Mycobacterium genavenseand avian polyomavirus co-infection in a European Goldfinch (Carduelis carduelis)

Relapsing Mycobacterium Genavense Infection as a Cause of Late Death in a Lung Transplant Recipient: Case Report and Review of the Literature

Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation

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