Disseminated non-tuberculous mycobacteriosis due to atypical type II—Mycobacteria gordonoe

Agents of newly recognized or infrequently encountered mycobacterial diseases

“…A patient undergoing continuous ambulatory peritoneal dialysis yielded multiple isolates in culture of a well-described typical M. gordonae from dialysis and ascitic-fluid specimens, and the symptomatic infection responded to a multiple-drug regimen including isoniazid, rifampin, and ethambutol complemented with limited courses of amikacin and pyrazinamide (112). A child with numerous granulomatous mesenteric lymph nodes containing many acid-fast bacilli as well as acid-fast bacilli in the bone marrow yielded a Tween-hydrolyzing scotochromogen that did not reduce nitrate; results of urease or quantitative catalase tests were not described (126). One (25).…”

“…Of 17 reports of non-AIDS cases, 8 contained insufficient evidence to conclude that the scotochromogen that was isolated, regardless of its identity, was actually causing disease (21,71,113,117,130,170). In the remaining nine cases, in which the Mycobacterium species isolated did appear to be playing a role in the disease, five of the scotochromogens isolated were insufficiently described to confirm their identity as a typical M. gordonae (14,31,100,126,194); one of the isolates, from the peritoneal dialysis patient (111) (155,175). Despite the limited features that can be used to distinguish among these three species (205,224), there is sufficient phenotypic distinction, as recognized in numerical taxonomic matrices (125,220), to meet the recommended (208) support for their nucleic acidbased separation (155,175).…”

Agents of newly recognized or infrequently encountered mycobacterial diseases.

“…A patient undergoing continuous ambulatory peritoneal dialysis yielded multiple isolates in culture of a well-described typical M. gordonae from dialysis and ascitic-fluid specimens, and the symptomatic infection responded to a multiple-drug regimen including isoniazid, rifampin, and ethambutol complemented with limited courses of amikacin and pyrazinamide (112). A child with numerous granulomatous mesenteric lymph nodes containing many acid-fast bacilli as well as acid-fast bacilli in the bone marrow yielded a Tween-hydrolyzing scotochromogen that did not reduce nitrate; results of urease or quantitative catalase tests were not described (126). One patient with a history of alcohol abuse developed liver disease, and a laparotomy disclosed diffuse peritoneal nodules with caseating necrosis (100).…”

“…Of 17 reports of non-AIDS cases, 8 contained insufficient evidence to conclude that the scotochromogen that was isolated, regardless of its identity, was actually causing disease (21,71,113,117,130,170). In the remaining nine cases, in which the Mycobacterium species isolated did appear to be playing a role in the disease, five of the scotochromogens isolated were insufficiently described to confirm their identity as a typical M. gordonae (14,31,100,126,194); one of the isolates, from the peritoneal dialysis patient (111), does fit the description of M. gordonae, and the fluid may simply have represented a culture medium for the organism. Three cultures, from lung (35), skin (58), and soft tissue (123), all exhibited characteristics that were atypical of M. gordonae and may have represented presently unrecognized taxa that closely resemble M. gordonae.…”