Disseminated Oligodendroglial-like Leptomeningeal Tumor in the Adult: Case Report and Review of the Literature

Fiaschi, Pietro; Badaloni, Filippo; Cagetti, Bernarda; Bruzzone, Luca; Marucci, Gianluca; Dellacha, A.; Pavanello, Marco; Ganci, Giuseppe; Padolecchia, Riccardo; Valsania, Valtero

doi:10.1016/j.wneu.2018.02.160

Cited by 23 publications

(22 citation statements)

References 14 publications

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“…The tumor is becoming increasingly recognized as having BRAF and KIAA1549 genes fusions, 1p deletions 2,6,9,13 and rarely 1p/19q codeletion 7,11 but a significant part of DLGNTs are negative for these markers. 2,3,6,8,10,12,14,16 In the reported case, the tumor showed BRAF and KIAA1549 fusion but without the most common BRAF gene mutations.…”

Section: Discussionmentioning

confidence: 63%

“…[5][6][7][8][9][10][11][12][13] Several cases in adults have been reported. 3,8,12 Most common symptoms include nausea and vomiting, 2-4,12-14 headache, [2][3][4][5][6][7]9,11,12,14 seizures, 11,12,15 limbs weakness, 2,4,7,9,11 loss of vision, 9,11 and altered mental state (confusion). 2,8,9 Our patient presented with headache, vomiting, and right eye convergent strabismus.…”

Section: Discussionmentioning

confidence: 99%

“…DLGNTs are typically positive for S100, Olig2, GFAP, and synaptophysin expression, 3,4,6,7,9 but immunoreactivity can differ between cases. The tumor is becoming increasingly recognized as having BRAF and KIAA1549 genes fusions, 1p deletions 2,6,9,13 and rarely 1p/19q codeletion 7,11 but a significant part of DLGNTs are negative for these markers.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical treatment has been also reported. 3,7 Clinical and symptomatic improvement was observed in 100% of patients receiving chemotherapy in the study conducted by Aguilera et al, 10 according to which chemotherapy seems to be effective in DLGNT treatment.…”

Section: Journal Of Pediatric Neurologymentioning

confidence: 98%

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Diffuse Leptomeningeal Glioneuronal Tumor in a 4.5-year-old Girl: A Case Report and Review of the Literature

Gabryś

Kuzaj

Pawełczak

et al. 2020

Journal of Pediatric Neurology

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Diffuse leptomeningeal glioneuronal tumor (DLGNT) is an entity introduced in 2016 World Health Organization classification of tumors of the central nervous system. The tumor occurs very rarely. Due to the lack of specific clinical and radiological features, biopsy is necessary to be performed and histological and immunohistochemical testing is essential to reach the diagnosis. A 4.5-year-old girl presented with a history of headache, vomiting, and right eye convergent squint. Imaging revealed multiple enhancing lesions located supra- and infratentorially and intramedullary. Histopathological examination demonstrated diffused growth of neoplastic cells. Molecular testing revealed KIAA1549-BRAF fusion and the diagnosis of DLGNT was stated.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Journal Of Pediatric Neurologymentioning

confidence: 98%

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Diffuse Leptomeningeal Glioneuronal Tumor in a 4.5-year-old Girl: A Case Report and Review of the Literature

Gabryś

Kuzaj

Pawełczak

et al. 2020

Journal of Pediatric Neurology

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“…Nevertheless, its genetic and epigenetic changes and its exact biological behavior are not yet fully known. 2,3 We described a late diagnosis of DLGNT in a patient that progressively developed hydrocephalus and polyradiculopathy. Clinical manifestations, imaging and histological characteristics are reported and discussed in the present paper to add evidence and advance current knowledge about the DLGNT.…”

Section: Introductionmentioning

confidence: 99%

A Diffuse Leptomeningeal Glioneural Tumor Case Producing Hydrocephalus and Polyradiculopathy

Picarelli

Nepomuceno

Ribeiro

et al. 2020

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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The present report describes the case of a male 17-year-old patient who progressively developed a hydrocephalus and polyradiculopathy due to involvement of central nervous system (CNS) by a diffuse leptomeningeal glioneuronal tumor (DLGNT). The tumor had partial remission in response to the treatment with radiotherapy plus procarbazine, lomustine, and vincristine (PCV) chemotherapy, and the patient had improvement in function and pain levels. The current knowledge about DLGNT, including its clinical manifestations, imaging findings, histological characteristics, and treatment are revised and discussed in the present paper.

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Unusual radiological and histological presentation of a diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 13-year-old girl

et al. 2019

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Disseminated Oligodendroglial-like Leptomeningeal Tumor in the Adult: Case Report and Review of the Literature

Cited by 23 publications

References 14 publications

Diffuse Leptomeningeal Glioneuronal Tumor in a 4.5-year-old Girl: A Case Report and Review of the Literature

Diffuse Leptomeningeal Glioneuronal Tumor in a 4.5-year-old Girl: A Case Report and Review of the Literature

A Diffuse Leptomeningeal Glioneural Tumor Case Producing Hydrocephalus and Polyradiculopathy

Unusual radiological and histological presentation of a diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 13-year-old girl

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