Disseminated Penicillium marneffei infection in Southeast Asia

Supparatpinyo, Khuanchai; Khamwan, Chantana; Baosoung, Vilai; Sirisanthana, Thira; Nelson, Kenrad E.

doi:10.1016/s0140-6736(94)91287-4

Cited by 545 publications

(525 citation statements)

References 22 publications

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“…A definitive diagnosis can be made only by direct visualization of the fungi using different staining techniques (355) or after culture from infected material (78).…”

Section: Other Regional Fungal Infectionsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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“…A definitive diagnosis can be made only by direct visualization of the fungi using different staining techniques (355) or after culture from infected material (78).…”

Section: Other Regional Fungal Infectionsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…20 Specific patient groups have very high frequencies of fungal infections: 15% of allogenic haemopoietic stem-cell transplant recipients have a fungal infection; 21 24 and Penicillium marneffei infections are present in about 30% of people with AIDS in south-east Asia. 25 In our study, a total of 48,155 samples yielded 555 fungal isolates. The largest numbers were from urine (n = 358) and catheter tip samples (n = 76).…”

Section: Discussionmentioning

confidence: 78%

Common fungal isolates from routine clinical specimens: a two years’ studyfrom a tertiary care hospital in South India

et al. 2017

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Background: Fungal infections are gaining prominence in recent years and are becoming a cause of significant morbidity as well as mortality. Reliable data from India about the spectrum of pathogens causing fungal infection in various body systems, and particularly about the antifungal susceptibility pattern of Candida spp., which is the most common isolate worldwide is not available. Methods:We prospectively studied 48,155 clinical samples submitted for fungal work-up to the microbiology laboratory at our tertiary care teaching hospital. Standard procedures were followed for fungal identification. Candida isolates were differentiated into Candida albicans and non-albicans candida (NAC) by germ tube test. Antifungal susceptibility of Candida isolates was determined by disc diffusion technique using amphotericin B (10 µg), fluconazole (25 µg), and voriconazole (1 µg) discs.Results: A total of 555 fungal isolates were obtained of which 541 were Candida spp, while the others were filamentous fungi. Male gender and age over 50 years were found to be independent risk factors. Proportion of NAC isolates (n = 384, 69.2%) were greater compared to C. albicans (n = 157, 28.3%). Aspergillus spp. was the second most frequent isolate. Azole resistance was significantly more in NAC group as compared to C. albicans. For fluconazole, 57.5% of the NAC showed resistance compared to 24.8% seen in strains of C. albicans while the corresponding figure for voriconazole was 56.8% Vs 22.9%. Overall resistance for amphotericin B was low (8.9%). Conclusions:Our observations bring to light the spectrum of common fungal isolates and their susceptibility patterns. This information will be useful for health planners and policy makers, as early institution of appropriate antifungal treatment can be life saving. Key words: Mycoses, Antifungal susceptibility testing, CandidaJayaprada R, Nagaraja M, Sumanth Kumar GLS, Venkataramana B, Kalawat U. Common fungal isolates from routine clinical specimens -A two-year study from a tertiary care hospital in South India. J Clin Sci Res 2017;6:2-9. DOI: http:// dx

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“…Definitive diagnosis requires culture of the pathogenic fungus from clinical specimens. Among all the clinical specimens studied, the bone marrow gives the highest yield for culture, approaching 100%, followed by skin biopsy (90%) and blood culture (76%) (Supparatpinyo et al, 1994). Serologic testing including various types of antigen and antibody testing specific to P. marneffei have been described but is of limited utility in penicilliosis (Wong & Wong, 2011).…”

Section: Penicilliosismentioning

confidence: 99%