Disseminated peripheral neuroblastoma in a Rhodesian Ridgeback dog

Cook, RW; Abraham, LA; McCowan, Christina

doi:10.1111/avj.12565

Cited by 6 publications

(8 citation statements)

References 18 publications

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“…In our patient, metastasis in the dura mater was detected based on necropsy findings alone, and invasion of the neoplasm through the esophageal hiatus of the diaphragm and its wide spread within the thoracic cavity was observed; to the best of our knowledge, this has not been previously described in the literature, and occurrence of epidural and intradural metastasis has only been reported in humans [4].…”

Section: Discussionmentioning

confidence: 41%

“…Analgesic therapy with dipyrone 1 (25 mg/kg tid), tramadol hydrochloride 2 (4 mg/kg bid), carprofen 3 (4.4 mg/kg sid), and supportive treatment with omeprazole 4 (1 mg/kg sid), and cobavital 5 (0.4 mg/kg) were administered. The hemogram revealed normocytic normochromic anemia and leukopenia due to lymphopenia, both discrete; serum biochemistry showed a slight decrease in alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase.…”

Section: Casementioning

confidence: 99%

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Metastatic Peripheral Neuroblastoma in a Dog

Sayeg

Oliveira

Santos

et al. 2019

Acta Scientiae. Vet.

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Background: Peripheral neuroblast neoplasms are considered as a group of tumors derived from primitive cells of the neural crest that are progenitors of the sympathetic ganglia and adrenal medulla. Reports of neuroblastoma in dogs are scarce in English literature, and there are no reports from Brazil due to its rare occurrence or missed diagnosis, because modern techniques are often not accessible in Brazil. The aim of the present study was reported a case of metastatic peripheral neuroblastoma in a 10-month-old bitch of Canadian Shepherd breed, attended at the Small Animal Veterinary Hospital of the Federal Rural University of Rio de Janeiro (HVPA-UFRRJ).Case: A 10-month-old female dog, Canadian Shepherd breed, presenting prostration, inappetence, emesis, progressive weight loss, and difficulties in the locomotion of the pelvic limbs was brought to the Small Animal Veterinary Hospital of the Federal Rural University of Rio de Janeiro (HVPA / UFRRJ) for treatment. Palpation of the abdominal cavity revealed a mass of approximately 14.0 cm diameter in the thoracolumbar region. After the second visit to HVPA/ UFRRJ, there was worsening of the clinical condition and onset of pain and dyspnea; hence, euthanasia was performed. The dog was referred for necropsy; the examination revealed a mass measuring 40.0 × 35.0 cm in the abdominal cavity that caused displacement of the intestines and compressed the liver against the diaphragm, as well as another mass that traversed the diaphragm through the esophageal hiatus and surrounded the esophagus, aorta, and caudal vena cava. The right adrenal gland was compressed and adhered to the mass, and the left adrenal gland was not visualized. Specimens of various organs were collected, fixed in 10% buffered formalin, and processed according to routine histological technique. Immunohistochemical examination performed on mass specimens revealed positivity for the anti-CD56, anti-synaptophysin, anti-GFAP, and anti-NSE markers and negativity for the anti-chromogranin and anti-Olig2 markers. Based on pathology and immunohistochemistry findings, a diagnosis of poorly differentiated peripheral neuroblastoma was made; in addition, presence of emboli of neoplastic cells in the hepatic sinusoids and branches of the portal vein and metastasis in the spleen, lymph nodes, lung, and meninges were confirmed.Discussion: Positive results for neural markers associated with negative results for those of other small round cell tumors was considered to indicate the presence of neuroblast tumors; glioblastoma and oligodendroglioma were ruled out based on the absence of anti-Olig2 labeling, and, especially, the possibility of occurrence of pheochromocytoma was excluded based on the absence of anti-chromogranin. During necropsy, the location of the mass at the retroperitoneal space near the thoracolumbar junction, craniomedially in relation to the left kidney, was confirmed, which is compatible with the location of the adrenal gland. Metastasis in the dura mater was determined to be present based on necropsy findings alone, and neoplastic invasion through the esophageal hiatus of the diaphragm of a large part of the thoracic cavity was observed, which, to the best of our knowledge, have not been described in reports of veterinary medicine. The high rate of tumor growth and compression and invasion of adjacent tissues and organs may be considered as potential factors for unfavorable prognosis of peripheral neuroblastoma.

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Section: Discussionmentioning

confidence: 41%

Section: Casementioning

confidence: 99%

Metastatic Peripheral Neuroblastoma in a Dog

Sayeg

Oliveira

Santos

et al. 2019

Acta Scientiae. Vet.

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“…Some of these signs were observed in the present case. These tumors usually have reached a considerable size before being detected and the prognosis is poor due to the advanced stage of the disease at the time of presentation (3, 4, 6–9). These tumors are large but often without signs of metastasis at the time of diagnosis, as encountered in this case, with X-ray, abdominal ultrasound, and thoraco-abdominal CT showing no metastatic-related findings.…”

Section: Discussionmentioning

confidence: 99%

“…In most cases, neuroblastomas occur in the abdominal cavity as large masses. Some neuroblastomas have an adrenal origin (2–8) while others have cervical and retropharyngeal origins (4, 8, 9).…”

Section: Introductionmentioning

confidence: 99%

Surgical Excision of an Adrenal Neuroblastoma in a Dog

et al. 2019

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A 11-month-old, intact male, Rhodesian Ridgeback was presented to the Veterinary Teaching Hospital with signs of inappetence, lethargy, and abdominal pain for 3 days. A large and well-defined abdominal retroperitoneal mass, related with the left kidney, at the expected location of the adrenal gland, was revealed by radiography, ultrasound, and computed tomography. The mass extended caudally to the iliac artery bifurcation, compressing the aorta, caudal vena cava, and both kidneys. Cytology findings were compatible with a malignant round cell tumor. The most probable diagnosis was neuroblastoma. Following a comprehensive discussion with the owners about a treatment plan, surgical excision was performed. Because a wide excision would compromise major vessels, excision was performed after careful dissection of the aorta and vena cava. The left kidney was removed because the proximal ureter could not be separated from the tumor. The animal recovered successfully. Diagnosis was confirmed by histopathology and immunohistochemistry, but the owners decided not to pursue any further treatment. Clinical signs of abdominal pain recurred within 1 month following surgery. Therefore, the animal was euthanized upon the owners' request. This report describes the diagnosis, surgical treatment, and follow-up of a dog with an abdominal peripheral neuroblastoma.

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“…Our final paper is a case report that thoroughly describes the clinical presentation and pathological work‐up of disseminated peripheral neuroblastoma in a Rhodesian Ridgeback dog . It is likely to be useful to clinicians, pathologists and both human and veterinary oncologists.…”

mentioning

confidence: 99%

In this issue – April 2017

Jackson¹

2017

Aust Veterinary J

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Disseminated peripheral neuroblastoma in a Rhodesian Ridgeback dog

Cited by 6 publications

References 18 publications

Metastatic Peripheral Neuroblastoma in a Dog

Metastatic Peripheral Neuroblastoma in a Dog

Surgical Excision of an Adrenal Neuroblastoma in a Dog

In this issue – April 2017

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