Disseminated Rhinocerebral Mucormycosis: A Case Report and Review of the Literature

O’Neill, Brian M.; Alessi, Anthony S.; George, Elsa B.; Piro, John D.

doi:10.1016/j.joms.2005.10.017

Cited by 47 publications

(33 citation statements)

References 53 publications

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“…Culturing the fungus from CSF occurs in less than 5% for Zygomycetes (12,13). Histopathological examination shows aseptate and irregular fungal hyphae branching with neutrophilic infiltrate invading the smaller blood vessels and causing necrosis (1,6,(9)(10)(11)14). We confirmed mucormycosis infection with histopathological examination in both cases.…”

Section: Discussionsupporting

confidence: 60%

“…Radiological studies such as CT or MRI show contrast enhancing masses within sinuses, cavernous sinus thrombosis, intracranial masses, brain abscesses and ischaemic infarcts in cases with mucormycosis (1,6,(9)(10)(11)14). The our first case, MRI revealed increase of soft tissues in the maxillary, sphenoid and ethmoid sinuses and contrast-enhancement of dura around the affected area and of extraocular muscles on the left side.…”

Section: Discussionmentioning

confidence: 66%

“…Zygomycetes location involves the cavernous sinus with the presentation of facial pain, cranial nerve palsies (cranial nerves III, IV, V and VI), proptosis and edema of the lids and retina (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Palatal ulcer was reported with rhinocerebral mucormycosis in literature (9).…”

Section: Discussionmentioning

confidence: 99%

“…Mucormycosis was first described by Paultauf in 1885 (1,2). The majority of cases have diagnosed in patients with immunologic and metabolic disorders such as diabetes mellitus, lymphoma, leukemia, myelodysplastic syndromes, prolonged corticosteroid therapies, acute renal failure, and severe burns (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

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Rhinocerebral Mucormycosis

YILDIZ¹

2012

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Rinoserebral mukormikozis nadir görülen, ilerleyici ve ölümcül olabilen oportunistik fungal bir infeksiyondur. Yüksek mortalite ve morbiditeye sahiptir. Erken tanı, medikal ve cerrahi tedavi prognozun düzelmesi için önemlidir. Biz, predispozan faktörü aplastik anemi ve akut myeloblastik lösemi olan iki olgu sunduk. Mukormikozis, olgularımızın etkilenen gözünde oküler hareketlerde bozulmaya, propitozise, kemozise ve hiperemiye neden olmuștur. Ayrıca ilk olgumuzda mukormikozis nedeni ile trigeminal sinirin birinci ve ikinci dalıda etkilenmiștir. Her iki olgumuzda da mukormikozis infeksiyonu histopatolojik olarak doğrulanmıștır. İlk olgumuzun manyetik rezonans görüntülemesinde sol taraftaki maksiller, sfenoid ve etmoid sinuste yumușak doku artıșı ve etkilenen bölge çevresindeki dura ve ekstraokuler kaslarda kontrast tutulumu mevcuttur. İkinci olgunun orbitofrontal bilgisayarlı tomografisinde sol frontal, maksiller, etmoid ve sfenoid sinuste radio-opasite ve sol etmoid sinusun kemik duvarında delikli destruksiyon vardır. Her iki olgumuzda antifungal tedavi verilmesine rağmen ölmüștür. Mukormikozisin bașarılı tedavisi için erken tanı, altta yatan predispozan risk faktörün düzelebilir olması, cerrahi debridman ve erken antifugal tedavi gerekmektedir.Anahtar Sözcükler: Rinoserebral mukormikozis, oküler palsi, presdispozan faktör, erken tanı, antifungal tedavi Rhinocerebral mucormycosis is a rare, progressive and fatal opportunistic fungal infection. It has high morbidity and mortality. Early diagnosis, medical and surgical management is necessary for improving prognosis. We reported two cases. Aplastic anemia and acute myeloblastic leukemia were predisposing factors in our cases. Mucormycosis caused ocular movement disorders, amaurosis, proptosis, chemosis and hyperemia on the affected eye in our cases. Furthermore, the first case had trigeminal palsy involving first and second divisions of the nerve due to mucormycosis. We confirmed mucormycosis infection with histopathological examination in both cases. In our first case, magnetic resonans imaging revealed increase of soft tissues in the maxillary, sphenoid and ethmoid sinuses and contrast-enhancement of dura around the affected area and of extraocular muscles on the left side. Orbitoparanasal computed tomography of the second case revealed radiopacity involving the left frontal, maxiller, ethmoid, sphenoid sinuses and spotty destruction of bony walls of the left ethmoid sinus. Although we gave prompt antifungal therapy in both cases, they died. Successful treatment of mucormycosis requires early diagnosis, reversal of underlying predisposing risk factors, surgical debridement and prompt antifungal therapy.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Rhinocerebral Mucormycosis

YILDIZ¹

2012

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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“…Amphotericin B deoxycholate (Amp B), and its lipid presentations, with less nephrotoxicity, remain the antifungals of choice for the treatment of mucormycosis (O'Neill et al, 2006;Uçkay et al, 2007). In cases of patients with mucormycosis refractory or intolerant to polyene therapy, posaconazole is considered an acceptable therapeutic option (Spellberg et al, 2009;Adegbola et al, 2009;Scheckenbach et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Mucormycosis of the head and neck: Report of five cases with different presentations

Ballester

González-García

García

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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Invasive rhinomaxillary mucormycosis: a case report with a review of the literature

et al. 2008

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Mucormycosis is a rare, often fatal disease that is caused by zygomycetes, which are common fungi frequently found in the soil and decaying vegetation. Diabetes mellitus, malnutrition, and an immunocompromised state favor the growth of various microorganisms, including zygomycetes and the normal fl ora of the oral cavity, which are otherwise nonpathogenic, leading to opportunistic infections. Here we report a case of mucormycosis presenting with extensive necrosis of the maxilla along with rhinocerebral involvement in a 60-year-old patient suffering from uncontrolled diabetes with ketoacidosis.

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Disseminated Rhinocerebral Mucormycosis: A Case Report and Review of the Literature

Cited by 47 publications

References 53 publications

Rhinocerebral Mucormycosis

Rhinocerebral Mucormycosis

Mucormycosis of the head and neck: Report of five cases with different presentations

Invasive rhinomaxillary mucormycosis: a case report with a review of the literature

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