Disseminated Scedosporium prolificans infection in a Labrador retriever with immune mediated haemolytic anaemia

Abstract

Disseminated scedosporiosis is rare in dogs and is usually reported in German Shepherds with suspected heritable immunodeficiency. This is the first report of disseminated scedosporiosis due to Scedosporium prolificans in a Labrador retriever dog that was receiving immunosuppressive drug therapy for treatment of immune-mediated haemolytic anaemia. Despite cessation of immunosuppressive medications and an initial response to aggressive treatment with voriconazole and terbinafine the dog developed progressive disease with neurological signs necessitating euthanasia six months from diagnosis.

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

“…(Smith et al 2007, Gemmill 2008. Além disso, em muitas outras enfermidades os protocolos terapêuticos utilizam drogas imunossupressoras como no lúpus, anemia hemolítica autoimune, pênfigo, tumores, e até alguns casos de encefalites (Smith et al 2007, Coates & Jeffery 2014, Nafe et al 2014, Taylor et al 2014.…”

Opportunistic Invasive Cutaneous Fungal Infections Associated with Administration of Cyclosporine to Dogs with Immune‐mediated Disease

“…Inhalation is thought to be the most common mode of infection for aspergillosis and hyalohyphomycosis, while cutaneous penetration or inhalation is common for phaeohyphomycosis . In distinction to previous reports, our study had only 1 case of disseminated fungal infection with a renal capsular granuloma, and the remaining 14 of 15 dogs had cutaneous lesions as the sole manifestation of OIFI, which is unique. There are relatively few case reports of OIFIs in immunosuppressed dogs and many of these reports are of disseminated systemic OIFIs.…”

“…infection; however, this appears to be uncommon. Infections with nonpigmented filamentous ascomycetes (aspergillosis and hyalohyphomycoses) and pigmented fungi (phaeohyphomycosis) are typical OIFIs in dogs . These organisms are ubiquitous soil saprophytes.…”

“…There have been individual case reports and 1 case series of 8 dogs describing OIFIs in immunosuppressed dogs. The case series of 8 dogs with OIFIs that had received cyclosporine and prednisone treatment emphasized the severe and occasionally fatal consequences of these infections .…”

SystemicScedosporium prolificansinfection in an 11‐month‐old Border collie with cobalamin deficiency secondary to selective cobalamin malabsorption (canine Imerslund‐Gräsbeck syndrome)

“…One case of disseminated S. prolificans infection has been described in a Labrador retriever receiving immunosuppressive drug therapy (Taylor et al . ) and one in a German shepherd dog with no history of immunosuppression (Haynes et al . ).…”