Disseminated <scp><i>M</i></scp><i>ycobacterium haemophilum</i> skeletal disease in a patient with interferon‐gamma deficiency

Otome, O.; O’Reilly, Mary

doi:10.1111/imj.12875

Cited by 8 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adult onset immunodeficiency related to the presence of anti-interferon (IFN)-γ antibodies in patients presenting with non-tuberculous mycobacterial (NTM) and other intracellular infections has been reported mostly in Asian populations. 1–6 This syndrome has also been reported in Caucasian and African individuals living in different settings around the world. 7–9 The biological mechanism underlying the pathogenesis of these antibodies remains to be elucidated.…”

Section: Introductionmentioning

confidence: 72%

Characterization of anti-interferon-γ antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms

Wipasa

Chaiwarith

Chawansuntati

et al. 2018

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

A major characteristic of immunodeficiency associated with life-threatening intracellular infection in adults is the presence of anti-interferon-γ antibodies. Although little is known about the mechanism underlying this syndrome, it is believed that the antibodies inhibit the activity of downstream signaling pathway of interferon-γ. In this study, the characteristics of these antibodies in patients who presented, or have a history of, intracellular infection and were positive to anti-interferon-γ antibodies were investigated. The antibodies exhibited mainly the IgG1 and the IgG4 subtypes and recognized the C-terminal of the interferon-γ linear epitope containing the KRKR motif, which is required for the biological activity of interferon-γ. The antibodies bound to recombinant interferon-γ with significantly lower avidity than antibodies to a recall antigen, tetanus toxoid, suggesting that the antibodies might have not undergone affinity maturation. The data from this study may provide fundamental information to better understand the properties of anti-interferon-γ antibodies, which can be useful for future studies. Impact statement An increase in the number of immunodeficient patients related to autoantibodies to interferon (IFN)-γ has been observed particularly in East Asian adults. These patients are often presented with opportunistic infections caused by intracellular pathogens, including non-tuberculous mycobacteria (NTM), Cryptococcus neoformans, Penicillium marneffei (now called Talaromyces marneffei), and non-typhoidal Salmonella spp. The mortality rate for this syndrome is relatively high with 32% patients dying at the median time of 25 months after diagnosis. Characterization of these autoantibodies may promote better understanding of the syndrome, an emerging health problem affecting East Asia populations and impeding their welfare and economic development.

show abstract

Section: Introductionmentioning

confidence: 72%

Characterization of anti-interferon-γ antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms

Wipasa

Chaiwarith

Chawansuntati

et al. 2018

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…Since 2004, some infectious diseases caused by opportunistic pathogens have been reported in adults without immunodeficiency (51)(52)(53)(54)(55). They were not infected with HIV but, similar to AIDS, showed clinical manifestations due to extremely low immunity.…”

Section: Anti-ifn-g Autoantibodies In Aoidmentioning

confidence: 99%

Anti-Interferon Autoantibodies in Adult-Onset Immunodeficiency Syndrome and Severe COVID-19 Infection

2021

View full text Add to dashboard Cite

Adult-onset immunodeficiency syndrome due to anti-interferon (IFN)-γ autoantibodies has attracted much attention in recent years. It usually occurs in previously healthy people and usually presents as chronic, recurrent, and hard-to-control infections that can be effectively treated with aggressive antibiotic therapy. Adult-onset immunodeficiency syndrome is also referred to as AIDS-like syndrome. Anti-type I IFN (IFN-I) autoantibodies have been reported to play a significant role in the pathogenesis of coronavirus disease 2019 (COVID-19) and preexisting anti-IFN-I autoantibodies are associated with an increased risk of severe COVID-19. This review summarizes the effects of anti-IFN autoantibodies on the susceptibility and severity of various infectious diseases, including SARS-CoV-2 infection. In addition, we discuss the role of anti-IFN autoantibodies in the pathogenesis of autoimmune diseases that are characterized by recurrent infections.

show abstract

“…The acquired immunodeficiency caused by production of anti-IFN-γ autoantibodies also leads to NTM infection [47]. Anti-IFN-γ autoantibodies are frequently found among Asian patients without acquired immune deficiency syndrome who exhibit disseminated NTM infection [48].…”

Section: Cellular-mediated Immune Responses To Ntm Infectionmentioning

confidence: 99%

Host Immune Response and Novel Diagnostic Approach to NTM Infections

Abe

Fukushima

Hosono

et al. 2020

IJMS

View full text Add to dashboard Cite

The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological responses play integral roles in vulnerability to NTM infections, and may contribute to the onset of specific types of NTM infection. Furthermore, distinct NTM species are known to affect and attenuate these host immune responses in unique manners. Therefore, host immune responses must be understood with respect to each causative NTM species. Here, we review innate, cellular-mediated, and humoral immunity to NTM and provide perspectives on novel diagnostic approaches regarding each NTM species.

show abstract

Disseminated Mycobacterium haemophilum skeletal disease in a patient with interferon‐gamma deficiency

Cited by 8 publications

References 13 publications

Characterization of anti-interferon-γ antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms

Characterization of anti-interferon-γ antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms

Anti-Interferon Autoantibodies in Adult-Onset Immunodeficiency Syndrome and Severe COVID-19 Infection

Host Immune Response and Novel Diagnostic Approach to NTM Infections

Contact Info

Product

Resources

About