Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B

Shin, Eun-Jae; Gwak, Min Jae; Jeong, Ki‐Heon; Lee, Mu-Hyoung

doi:10.5021/ad.2018.30.2.249

Cited by 4 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Remaining patients had inflammatory conditions such as Crohn's disease (n = 1) and vitiligo (n = 2). Only one patient had a reported family history of porokeratosis 8 …”

Section: Resultsmentioning

confidence: 99%

“…6 In addition, the administration of artificial ultraviolet light in experimental and therapeutic settings has resulted in the induction of DSAP lesions. 7,8 This is also supported by the fact that DSAP preferentially occurs on areas of sun-exposed skin and in individuals with histories of extensive sun exposure. 1 Porokeratosis has also been shown to develop in immunodeficient patients and its incidence is estimated to be between 0.34% and 10.68% for patients undergoing organ transplant with immunosuppressive agents.…”

Section: Introductionmentioning

confidence: 82%

“…Porokeratosis is also linked to sun exposure and artificial irradiation such as PUVA 5 ; and has also been induced with irradiation 6 . In addition, the administration of artificial ultraviolet light in experimental and therapeutic settings has resulted in the induction of DSAP lesions 7,8 . This is also supported by the fact that DSAP preferentially occurs on areas of sun‐exposed skin and in individuals with histories of extensive sun exposure 1 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Drugs associated with development of porokeratosis: A systematic review

Mufti

Sachdeva

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Porokeratosis is a rare disorder characterized by atrophic macules or patches, with a well‐defined ridge‐like hyperkeratotic border called cornoid lamella. Although the exact pathogenesis is unknown, drug associated cases have recently been reported in the literature. As such, we systematically reviewed and identified drugs associated with drug‐induced porokeratosis, their resultant effects, and whether there was a casual relationship between the use of a drug and the development of porokeratosis. We searched for articles which reported drug‐induced porokeratosis in MEDLINE and Embase in June 2020. After full‐text review, 25 studies were included for analysis. We identified 26 patients with drug‐induced porokeratosis. The most common therapies associated with development of porokeratosis is biologic use, phototherapy, and radiotherapy. The most common clinical variants were the disseminated superficial or actinic types (60%), which occurred in psoriasis patients undergoing phototherapy, and eruptive disseminated type (24%) which occurred in the context of biologic therapies. The Naranjo score ranged from possible to probable for the identified treatments. Clinicians should consider drug reactions as possible triggering events for porokeratosis, especially for patients taking biologics, phototherapy, and radiotherapy. Large‐scale studies are required to confirm our findings and further explore the pathogenesis for drug‐induced porokeratosis.

show abstract

“…Remaining patients had inflammatory conditions such as Crohn's disease (n = 1) and vitiligo (n = 2). Only one patient had a reported family history of porokeratosis 8 …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Drugs associated with development of porokeratosis: A systematic review

Mufti

Sachdeva

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Accordingly, vitiliginous skin is more vulnerable to these influences in comparison with normally pigmented skin. People with vitiligo show the same and even a lower incidence of cutaneous malignancies than other populations [1,8,9]. Some ascribe this to the increased expression of the tumorsuppressing gene TP53 in vitiligo [10,11].…”

Section: Case Reportmentioning

confidence: 99%

“…Porokeratosis is a keratinization skin disorder inherited as an autosomal dominant [1]. Disseminated superficial actinic porokeratosis (DSAP) is characterized by annular keratotic papules or plaques with a characteristic thread-like ridge and central atrophy that expand peripherally on sunexposed skin [2].…”

Section: Introductionmentioning

confidence: 99%

Disseminated superficial actinic porokeratosis in a patient with generalized vitiligo: A case report

Mancy¹

2021

Our Dermatol Online

View full text Add to dashboard Cite

Disseminated superficial actinic porokeratosis (DSAP) is the most common type of porokeratosis, occurring mainly on sun-exposed skin. Chronic sun exposure is one of the main risk factors, in addition to genetic susceptibility. Most published data concerning the relationship between vitiligo and its predisposition to nonmelanoma skin cancer suggests that patients with vitiligo show the same or even a lower incidence than other populations. Herein, we report a case of disseminated superficial actinic porokeratosis occurring in vitiligo in which chronic sun exposure was the main risk factor

show abstract

Rare dermatosis is disseminated actinic superficial porokeratosis

Schava,

Shishkina

2024

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

Porokeratoses are a very rare group of dermatoses, acquired or hereditary, of unknown etiology, characterized by a violation of keratinization. The disease is manifested by one or more atrophic spots, each of which is surrounded by a characteristic hyperkeratotic, ridge-like border called a "horny plate". There are several forms of this pathology, among which there are sporadic cases and family variants with an autosomal dominant pattern of inheritance of various penetrance. This article presents a clinical case of the occurrence of superficial disseminated actinic porokeratosis in a 59-year-old woman after prolonged exposure to the sun. The eruptions were represented by small spots, rounded, pinkish-yellow-brown in color with an atrophic center, surrounded by a raised narrow roller with a groove on the surface, have no tendency to merge, symmetrically arranged. Screening for diseases that cause immunosuppression (human immunodeficiency virus, hematological malignancies) and renal insufficiency did not reveal pathology. Histological examination showed a typical well-limited plume of parakeratotic cells (horn plate), hypogranulosis, dyskeratotic cells or vacuolated keratinocytes, which made it possible to make a final diagnosis. Considering that insolation in this case is a causally significant factor and the likelihood of malignant neoplasms against the background of dermatosis remains, it is extremely important for such patients to use sunscreens with a high degree of protection as part of complex therapy, as well as regular skin examinations.

show abstract

Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B

Cited by 4 publications

References 4 publications

Drugs associated with development of porokeratosis: A systematic review

Drugs associated with development of porokeratosis: A systematic review

Disseminated superficial actinic porokeratosis in a patient with generalized vitiligo: A case report

Rare dermatosis is disseminated actinic superficial porokeratosis

Contact Info

Product

Resources

About