Disseminated toxoplasmosis in a heart transplant patient despite co-trimoxazole prophylaxis: A case report

Dávila, Victoria; Roncancio-Villamil, Gustavo; Correa, Luis Alfonso; Restrepo, Catalina; Madrid, Camilo Alberto; González, Javier Mauricio

doi:10.7705/biomedica.v37i3.3189

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Empiric prophylaxis has been shown to decrease the risk of toxoplasmosis in recipients receiving seropositive donor hearts although breakthrough infection can occur despite prophylaxis . Studies differ on the impact of donor/recipient mismatching and outcome for toxoplasmosis.…”

Section: Donor Infectionsmentioning

confidence: 99%

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Conway

Ballweg

Fenton

et al. 2020

Pediatric Transplantation

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Heart transplantation (HTx) is a treatment option for end‐stage heart failure in children. HTx is limited by the availability and acceptability of donor hearts. Refusal of donor hearts has been reported to be common with reasons for refusal including preexisting donor characteristics. This review will focus on the impact of donor characteristics and comorbidities on outcomes following pediatric HTx. A literature review was performed to identify articles on donor characteristics and comorbidities and pediatric HTx outcomes. There are many donor characteristics to consider when accepting a donor heart. Weight‐based matching is the most common form of matching in pediatric HTx with a donor‐recipient weight ratio between 0.7 and 3 having limited impact on outcomes. From an age perspective, donors <50 years can be carefully considered, but the impact of ischemic time needs to be understood. To increase the donor pool, with minimal impact on outcomes, ABO‐incompatible donors should be considered in patients that are eligible. Other factors to be considered when accepting an organ is donor comorbidities. Little is known about donor comorbidities in pediatric HTx, with most of the data available focusing on infections. Being aware of the potential infections in the donor, understanding the testing available and risks of transmission, and treatment options for the recipient is essential. There are a number of donor characteristics that potentially impact outcomes following pediatric HTx, but these need to be taken into consideration along with their interactions with recipient factors when interpreting the outcomes following HTx.

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Section: Donor Infectionsmentioning

confidence: 99%

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Conway

Ballweg

Fenton

et al. 2020

Pediatric Transplantation

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“…The infection is transmitted via ingestion of drinking water, food, or soil contaminated with the oocysts in the cat's feces and consumption of raw meat (1). Other transmission routes are organ transplantation and congenital transmission of toxoplasmosis (2)(3)(4). The infection has been reported only based on regional studies.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and Molecular Investigation of Toxoplasmosis Among Working Children in Tehran

Bokharaei‐Salim

Khanaliha

Sayyahfar

et al. 2022

Arch Pediatr Infect Dis

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Background: Toxoplasma gondii is a pathogenic protozoan that causes toxoplasmosis and spreads worldwide. Objectives: This study aimed to investigate the prevalence of toxoplasmosis by serological and molecular methods in working children and a control group in Tehran. Methods: The study participants comprised 460 children aged 7 - 14 years, including 278 working children and 182 age-matched controls. Blood samples were collected, and a serological test was performed to evaluate IgM and IgG antibodies against T. gondii. Peripheral blood mononuclear cells (PBMCs) were isolated from the blood specimens by gradient centrifugation method. Real-time polymerase chain reaction (PCR) was performed using primer B1 on PBMC samples in children’s blood to determine the status of Toxoplasma infection. Results: Seroprevalence of IgG and IgM antibodies against T. gondii was 24.8% and 0.7%, respectively, in working children; however, in the control group, 12.1% and 2.2% had IgG and IgM antibodies against T. gondii, respectively. The mean IgG titer was 160 ± 86.39 IU/mL and 69.36 ± 88 IU/mL for working children and the control group, respectively (P < 0.0001); however, the mean IgM titer was 4.65 ± 3.04 IU/mL and 3.85 ± 4 IU/mL for working children and control group, respectively (P = 0.8187). Real-time PCR results indicated two (0.7%) positive cases among working children and three (1.65%) samples in the control group. The present study showed a significant difference between working children and the control group regarding the frequency of IgG antibodies (P = 0.0012). However, there was no significant difference in the frequency of IgM antibodies in the two mentioned groups. Conclusions: Seroprevalence of IgG antibody against T. gondii was more in working children than in the control group in Tehran. This investigation revealed a significant difference in frequency and titer of IgG antibodies between working children and the control group. More exposure to the soil and contaminated hands before drinking water or food may be considered factors in the development of toxoplasmosis infection in these children.

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Disseminated toxoplasmosis in a heart transplant patient despite co-trimoxazole prophylaxis: A case report

Cited by 5 publications

References 21 publications

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Seroprevalence and Molecular Investigation of Toxoplasmosis Among Working Children in Tehran

Immunosuppressants

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